Selenomethionine Prevents Degeneration Induced by Overexpression of Wild-Type Human α-Synuclein during Differentiation of Neuroblastoma Cells

Journal of the American College of Nutrition

Volumn 24, Issue 6, 2005, Pages 516-523

  Kumar, Bipin ^a   Nahreini, Piruz ^a   Hanson, Amy J ^a   Andreatta, Cynthia ^a   Prasad, Judith E ^a   Prasad, Kedar N ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Degeneration; Differentiated neuroblastoma cells; Human wild type synuclein; Prevention; Selenomethionine

Indexed keywords

ALPHA SYNUCLEIN; SELENOMETHIONINE; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; ADENYLATE CYCLASE ACTIVATOR; BUCLADESINE; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ENZYME INHIBITOR; LACTATE DEHYDROGENASE; METHIONINE; PROSTAGLANDIN A1; SODIUM SELENITE;

ANIMAL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; MOUSE; NEUROBLASTOMA; OXIDATIVE STRESS; PATHOLOGY; ANIMAL CELL; CELL CLONE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; NERVE CELL DEGENERATION; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; ANIMALS; CELL DIFFERENTIATION; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; NEUROBLASTOMA; OXIDATIVE STRESS; SELENOMETHIONINE; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 33644841436     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2005.10719498     Document Type: Article

References (55)

1. Duda JE, Shah U, Arnold SE, Lee VM, Trojanowski JQ: The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases. Exp Neurol 160: 515-522, 1999.
2. George JM: The synucleins. Genome Biol 3: REVIEWS3002, 2002.
3. Perrin RJ, Woods WS, Clayton DF, George JM: Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J Biol Chem 276: 41958-41962, 2001.
4. Dawson TM, Dawson VL: Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819-822, 2003.
5. Outeiro TF, Lindquist S: Yeast cells provide insight into alphasynuclein biology and pathobiology. Science 302: 1772-1775, 2003.
6. Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ: The formation of highly soluble oligomers of alphasynuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 37: 583-595, 2003.
7. Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM: Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34: 521-533, 2002.
8. Lee MK, Stirling W, Xu Y, Xu X, Qui D, Mandir AS, Dawson TM, Copeland NG, Jenkins NA, Price DL: Human alphasynuclein-harboring familial Parkinson's disease-linked Ala-53 Thr mutation causes neurodegenerative disease with alphasynuclein aggregation in transgenic mice. Proc Natl Acad Sci USA 99: 8968-8973, 2002.
9. Kruger R, Muller T, Riess O: Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders. J Neural Trans 107: 31-40, 2000.
10. Lucking CB, Brice A: Alpha-synuclein and Parkinson's disease. Cell Mol Life Sci 57: 1894-1908, 2000.
11. el-Agnaf OM, Irvine GB: Aggregation and neurotoxicity of alphasynuclein and related peptides. Biochem Soc Trans 30: 559-565, 2002.
12. Hashimoto M, Masliah E: Alpha-synuclein in Lewy body disease and Alzheimer's disease. Brain Pathol 9: 707-720, 1999.
13. Yokota O, Terada S, Ishizu H, Ujike H, Ishihara T, Nakashima H, Yasuda M, Kitamura Y, Ueda K, Checler F, Kuroda S: NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases. Acta Neuropathol (Berl) 104: 637-648, 2002.
14. Lippa CF, Schmidt ML, Lee VM, Trojanowski JQ: Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann Neurol 45: 353-357, 1999.
15. Dawson T, Mandir A, Lee M: Animal models of PD: pieces of the same puzzle? Neuron 35: 219-222, 2002.
16. Hegde ML, Jagannatha Rao KS: Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease. Arch Biochem Biophys 418: 169-178, 2003.
17. Zhou W, Schaack J, Zawada WM, Freed CR: Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture. Brain Res 926: 42-50, 2002.
18. Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P: alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci USA 99: 10813-10818, 2002.
19. Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, Lillystone S, Kehoe P, Rudrasingham V, Jones L, Lovestone S, Perez-Tur J, Williams J, Owen MJ, Hardy J, Goate AM: Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290: 2304-2305, 2000.
20. Yankner BA, Mesulam MM: Seminars in medicine of the Beth Israel Hospital, Boston, beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med 325: 1849-1857, 1991.
21. Selkoe DJ: Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol 10: 373-403, 1994.
22. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356, 2002.
23. Wang GP, Khatoon S, Iqbal K, Grundke-Iqbal I: Brain ubiquitin is markedly elevated in Alzheimer disease. Brain Res 566: 146-151, 1991.
24. Hashimoto M, Hsu LJ, Rockenstein E, Takenouchi T, Mallory M, Masliah E: alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells. J Biol Chem 277: 11465-11472, 2002.
25. Lee M, Hyun D, Halliwell B, Jenner P: Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult. J Neurochem 76: 998-1009, 2001.
26. Kholodilov NG, Oo TF, Burke RE: Synuclein expression is decreased in rat substantia nigra following induction of apoptosis by intrastriatal 6-hydroxydopamine. Neurosci Lett 275: 105-108, 1999.
27. Prasad KN: Differentiation of neuroblastoma cells: a useful model for neurobiology and cancer. Biol Rev Camb Philos Soc 66: 431-451, 1991.
28. Hanson AJ, Prasad JE, Nahreini P, Andreatta C, Kumar B, Yan XD, Prasad KN: Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells. J Neurosci Res 74: 148-159, 2003.
29. Prasad KN, Mandal B, Waymire JC, Lees GJ, Vernadakis A, Weiner N: Basal level of neurotransmitter synthesizing enzymes and effect of cyclic AMP agents on the morphological differentiation of isolated neuroblastoma clones. Nat New Biol 241: 117-119, 1973.
30. Montine TJ, Sidell KR, Crews BC, Markesbery WR, Marnett LJ, Roberts LJ, Morrow JD: Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 53: 1495-1498, 1999.
31. Pear WS, Nolan GP, Scott ML, Baltimore D: Production of hightiter helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 90: 8392-8396, 1993.
32. Nahreini P, Hovland AR, Kumar B, Andreatta C, Edwards-Prasad J, Prasad KN: Effects of altered cyclophilin A expression on growth and differentiation of human and mouse neuronal cells. Cell Mol Neurobiol 21: 65-79, 2001.
33. Hashimoto M, Yoshimoto M, Sisk A, Hsu LJ, Sundsmo M, Kittel A, Saitoh T, Miller A, Masliah E: NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation. Biochem Biophys Res Commun 237: 611-616, 1997.
34. Kumar B, Andreatta C, Koustas WT, Cole WC, Edwards-Prasad J, Prasad KN: Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. J Neurosci Res 68: 627-635, 2002.
35. Hovland AR, Nahreini P, Andreatta CP, Edwards-Prasad J, Prasad KN: Identifying genes involved in regulating differentiation of neuroblastoma cells. J Neurosci Res 64: 302-310, 2001.
36. Prasad JE, Kumar B, Andreatta C, Nahreini P, Hanson AJ, Yan XD, Prasad KN: Over-expression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E2, hydrogen peroxide and a nitric oxide donor in differentiated neuroblastoma cells. J Neurosci Res, in press.
37. Nahreini P, Andreatta C, Kumar B, Hanson A, Edwards-Prasad J, Freed CR, Prasad KN: Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells. Cell Mol Neurobiol 23: 27-42, 2003.
38. Checler F, da Costa CA, Ancolio K, Chevallier N, Lopez-Perez E, Marambaud P: Role of the proteasome in Alzheimer's disease. Biochim Biophys Acta 1502: 133-138, 2000.
39. Rockwell P, Yuan H, Magnusson R, Figueiredo-Pereira ME: Proteasome inhibition in neuronal cells induces a proinflammatory response manifested by upregulation of cyclooxygenase-2, its accumulation as ubiquitin conjugates, and production of the prostaglandin PGE(2). Arch Biochem Biophys 374: 325-333, 2000.
40. Gregori L, Hainfeld JF, Simon MN, Goldgaber D: Binding of amyloid beta protein to the 20 S proteasome. J Biol Chem 272: 58-62, 1997.
41. Prasad KN, Hovland AR, La Rosa FG, Hovland PG: Prostaglandins as putative neurotoxins in Alzheimer's disease. Proc Soc Exp Biol Med 219: 120-125, 1998.
42. Prasad KN, La Rosa FG, Prasad JE: Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid. In Vitro Cell Dev Biol Anim 34: 265-274, 1998.
43. Hsu LJ, Sagara Y, Arroyo A, Rockenstein E, Sisk A, Mallory M, Wong J, Takenouchi T, Hashimoto M, Masliah E: alpha-synuclein promotes mitochondrial deficit and oxidative stress. Am J Pathol 157: 401-410, 2000.
44. Ambani LM, Van Woert MH, Murphy S: Brain peroxidase and catalase in Parkinson disease. Arch Neurol 32: 114-118, 1975.
45. Kish SJ, Morito C, Hornykiewicz O: Glutathione peroxidase activity in Parkinson's disease brain. Neurosci Lett 58: 343-346, 1985.
46. Sofic E, Lange KW, Jellinger K, Riederer P: Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. Neurosci Lett 142: 128-130, 1992.
47. Dexter DT, Holley AE, Flitter WD, Slater TF, Wells FR, Daniel SE, Lees AJ, Jenner P, Marsden CD: Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov Disord 9: 92-97, 1994.
48. Sanchez-Ramos J, Overvik E, Ames B: A marker of oxyradicalmediated DNA damage (8-hydroxy-2-deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain. Neurodegeneration 3: 197-204, 1994.
49. Ebadi M, Srinivasan SK, Baxi MD: Oxidative stress and antioxidant therapy in Parkinson's disease. Prog Neurobiol 48: 1-19, 1996.
50. Schubert D, Behl C, Lesley R, Brack A, Dargusch R, Sagara Y, Kimura H: Amyloid peptides are toxic via a common oxidative mechanism. Proc Natl Acad Sci U S A 92: 1989-1993, 1995.
51. Behl C, Davis J, Cole GM, Schubert D: Vitamin E protects nerve cells from amyloid beta protein toxicity. Biochem Biophys Res Commun 186: 944-950, 1992.
52. Pappolla MA, Chyan YJ, Omar RA, Hsiao K, Perry G, Smith MA, Bozner P: Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Am J Pathol 152: 871-877, 1998.
53. Zaman Z, Roche S, Fielden P, Frost PG, Niriella DC, Cayley AC: Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease. Age Ageing 21: 91-94, 1992.
54. Koppal T: Peroxynitrite-mediated damage to brain membrane alterations in Alzheimer's disease (AD). Soc Neurosci 24: 1217a, 1998.
55. Conrad CC, Marshall PL, Talent JM, Malakowsky CA, Choi J, Gracy RW: Oxidized proteins in Alzheimer's plasma. Biochem Biophys Res Commun 275: 678-681, 2000.