Human brain derived cell culture models of HIV-1 infection

Neurotoxicity Research

Volumn 8, Issue 1-2, 2005, Pages 83-89

  Seth, Pankaj ^a   Major, Eugene O ^b  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Aids dementia complex; Astrocytes; Cell culture systems; Encephalopathy; HIV associated dementia; HIV 1; Infection; Lymphocytes; Microglia; Neuropathogenesis

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; BRAIN; CELL CULTURE; CYTOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PATHOLOGY; REVIEW; STEM CELL; VIROLOGY;

AIDS DEMENTIA COMPLEX; BRAIN; CELLS, CULTURED; HIV INFECTIONS; HIV-1; HUMANS; STEM CELLS;

EID: 33644834744     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033821     Document Type: Article

References (88)

1. Andras IE, H Pu, MA Deli, A Nath, B Hennig and M Toborek (2003) HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells. J. Neurosci. Res. 74(2), 255-265.
2. Bachis A, EO Major and I Mocchetti (2003) Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. J. Neurosci. 23, 5715-5722.
3. Bell JE (2004) An update on the neuropathology of HIV in the HAART era. Histopathology 45(6), 549-559.
4. Bloom FE and DM Rausch (1997) HIV in the brain, pathology and neurobehavioral consequences. J. Neurovirol. 3(2), 102-109.
5. Bockstahler LE, T Werner, H Festl, S Weis, KM Einhaeup, V Erfle and R Brack-Werner (1995) Distribution of HIV genomic DNA in brains of AIDS patients. Clin. Diagn. Virol. 3, 61-72.
6. Brack-Werner R (1999) Astrocytes, HIV cellular reservoirs and important participants in neuropathogenesis. Aids 13, 1-22.
7. Brana C, TE Biggs, CH Barton, LE Sundstrom and DA Mann (1999) A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 Tat in vitro. Aids 13(12), 1443-1452.
8. Brown LK, KJ Lourie and M Pao (2000) Children and adolescents living with HIV and AIDS, a review. J. Child Psychol. Psychiatry 41, 81-96.
9. Cheng-Mayer C, JT Rutka, ML Rosenblum, T McHugh. DP Stites and JA Levy (1987) Human immunodeficiency virus can productively infect cultured human glial cells. Proc. Natl. Acad. Sci. USA 84(10), 3526-3530.
10. Chiodi F, S Fuerstenberg, M Gidlund, B Asjo and EM Fenyo (1987) Infection of brain-derived cells with the human immunodeficiency virus. J. Virol. 61(4), 1244-1247.
11. Christofinis G, L Papadaki, Q Sattentau, RB Ferns and R Tedder (1987) HIV replicates in cultured human brain cells. Aids 1, 229-234.
12. Conant K, A Garzino-Demo, A Nath, JC McArthur, W Halliday, C Power, RC Gallo and EO Major (1998) Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc. Natl. Acad. Sci. USA 95(6), 3117-3121.
13. Conant K, C St Hillaire, C Anderson, D Galey, J Wang and A Nath (2004) Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases. J. Neurovirol. 10(1), 21-28.
14. Dallasta LM, LA Pisarov, JE Esplen, JV Werley, AV Moses, JA Nelson and CL Achim (1999) Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am. J. Pathol. 155(6), 1915-1927.
15. D'Aversa TG, KO Yu and JW Berman (2004) Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat. J. Neurovirol. 10(2), 86-97.
16. Davis LE, BL Hjelle, VE Miller, DL Palmer, AL Llewellyn, TL Merlin, SA Young, RG Mills, W Wachsman and CA Willey (1992) Early viral brain invasion in iatrogenic human immunodeficiency virus infection. Neurology 42(9), 1736-1739.
17. Dore GJ, PK Correll, Y Li, JM Kaldor, DA Cooper and BJ Brew (1999) Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. Aids 13(10), 1249-1253.
18. Dreyer EB and SA Lipton (1995) The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. Eur. J. Neurosci. 7, 2502-2507.
19. Du Pasquier RA, S Corey, DH Margolin, K Williams, LA Pfister, U De Girolami, JJ MacKey, C Wuthrich, JT Joseph and IJ Koralnik (2003) Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual. Neurology 61(6), 775-782.
20. Ensoli F, B Ensoli and CJ Thiele (1994) HIV-1 gene expression and replication in neuronal and glial cell lines with immature phenotype: effects of nerve growth factor. Virology 200, 668-676.
21. Ensoli F, A Cafaro, V Fiorelli, B Vannelli, B Ensoli and CJ Thiele (1995) HIV-1 Infection of primary human neuroblasts. Virology 210, 221-225.
22. Ensoli F, H Wang, V Fiorelli, S Zeichner, MR De Cristofaro, G Luzi and CJ Thiele (1997) HIV-1 infection and the developing nervous system, lineage-specific regulation of viral gene expression and replication in distinct neuronal precursors. J. Neurovirol. 3(4), 290-298. Review.
23. Epstein LG, LR Sharer, VV Joshi, MM Fojas, MR Koenigsberger and JM Oleske (1985) Progressive encephalopathy in children with acquired immune deficiency syndrome. Ann. Neurol. 17, 488-496.
24. Eugenin EA, G Dyer, TM Calderon and JW Berman (2005) HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism, possible role in NeuroAIDS. Glia 49(4), 501-510.
25. Fontana G, L Valenti and M Raiteri (1997) Gp120 can revert antagonism at the glycine site of NMDA receptors mediating GABA release from cultured hippocampal neurons. J. Neurosci. Res. 49, 732-738.
26. Gonzalez-Scarano F and J Martin-Garcia (2005) The neuropathogenesis of AIDS. Nat. Rev. Immunol. 5(1), 69-81.
27. Gorry P, D Purcell, J Howard and D McPhee (1998) Restricted HIV-1 infection of human astrocytes, potential role of nef in the regulation of virus replication. J. Neurovirol. 4, 377-386.
28. Gray F, F Scaravilli, I Everall, F Chretien, S An, D Boche, H Adle-Biassette, L Wingertsmann, M Durigon, B Hurtrel, F Chiodi, J Bell and P Lantos (1996) Neuropathology of early HIV-1 infection. Brain Pathol. 6, 1-15.
29. Hao HN, FC Chiu, L Losev, KM Weidenheim, WK Rashbaum and WD Lyman (1997) HIV infection of human fetal neural cells is mediated by gp120 binding to a cell membrane-associated molecule that is not CD4 nor galactocerebroside. Brain Res. 764, 149-157.
30. He J, Y Chen, M Farzan, H Choe, A Ohagen, S Gartner, J Busciglio, X Yang, W Hofmann, W Newman, CR Mackay, J Sodroski and D Gabuzda (1997) CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385(6617), 645-649.
31. Hesselgesser J, D Taub, P Baskar, M Greenberg, J Hoxie, DL Kolson and R Horuk (1998) Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4. Curr. Biol. 8(10), 595-598.
32. Hurwitz AA, JW Berman and WD Lyman (1994) The role of the blood-brain barrier in HIV infection of the central nervous system. Adv. Neuroimmunol. 4, 249-256.
33. Klein RS, T Flanigan, P Schuman, D Smith and D Vlahov (1999) The effect of immunodeficiency on cutaneous delayed-type hypersensitivity testing in HIV-infected women without anergy: Implications for tuberculin testing. HER Study Group. HIV Epidemiology Research. Int. J. Tuberc. Lung Dis. 3(8), 681-688.
34. Kolson DL (2002) Neuropathogenesis of central nervous system HIV-1 infection. Clin. Lab. Med. 22(3), 703-717.
35. Krathwohl MD and JL Kaiser (2004a) Chemokines promote quiescence and survival of human neural progenitor cells. Stem Cells 22, 109-118.
36. Krathwohl MD and JL Kaiser (2004b) HIV-1 promotes quiescence in human neural progenitor cells. J. Infectious Dis. 190, 216-226.
37. Kruman II, A Nath and MP Mattson (1998) HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp. Neurol. 154, 276-288.
38. Kutsch O, J Oh, A Nath and EN Benveniste (2000) Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes. J. Virol. 74, 9214-9221.
39. Langford TD, SL Letendre, GJ Larrea and E Masliah (2003) Changing patterns in the neuropathogenesis of HIV during the HAART era. Brain Pathol. 13(2), 195-210.
40. Lannuzel A, JV Barnier, C Hery, VT Huynh, B Guibert, F Gray, JD Vincent and M Tardieu (1997) Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons. Ann. Neurol. 42(6), 847-856.
41. Lassen K, Y Han, Y Zhou, J Siliciano and RF Siliciano (2004) The multifactorial nature of HIV-1 latency. Trends Mol. Med. 10(11), 525-531.
42. Lavi E, JM Strizki, AM Ulrich, W Zhang, L Fu, Q Wang, M O'Connor, JA Hoxie and F Gonzalez-Scarano (1997) CXCR-4 (fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am. J. Pathol. 151, 1035-1042.
43. Lavi E, DL Kolson, AM Ulrich, L Fu and F Gonzalez-Scarano (1998) Chemokine receptors in the human brain and their relationship to HIV infection. J. Neurovirol. 4, 301-311.
44. Lawrence DM, LC Durham, L Schwartz, P Seth, D Maric and EO Major (2004) Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells. J. Virol. 78(14), 7319-7328.
45. Liu Y, H Liu, BO Kim, VH Gattone, J Li, A Nath, J Blum and JJ He (2004) CD4-independent infection of astrocytes by human immunodeficiency virus type 1, requirement for the human mannose receptor. J. Virol. 78 (8), 4120-4133.
46. Magnuson DS, BE Knudsen, JD Geiger, RM Brownstone and A Nath (1995) Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann. Neurol. 37, 373-380.
47. Marras D, LA Bruggeman, F Gao, N Tanji, MM Mansukhani, A Cara, MD Ross, GL Gusella, G Benson, VD D'Agati, BH Hahn, ME Klotman and PE Klotman (2002) Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat. Med. 8, 522-526.
48. Maschke M, O Kastrup, S Esser, B Ross, U Hengge and A Hufnagel (2000) Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J. Neurol. Neurosurg. Psychiatry 69, 376-380.
49. Masliah E, RM DeTeresa, ME Mallory and LA Hansen (2000) Changes in pathological findings at autopsy in AIDS cases for the last 15 years. Aids 14, 69-74.
50. McArthur JC (2004) HIV dementia, an evolving disease. J. Neuroimmunol. 157 (1-2), 3-10.
51. McArthur JC, DR McClernon, MF Cronin, TE Nance-Sproson, AJ Saah, M St Clair and ER Lanier (1997) Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann. Neurol. 42 (5), 689-698.
52. McArthur JC, N Haughey, S Gartner, K Conant, C Pardo, A Nath and N Sacktor (2003) Human immunodeficiency virus-associated dementia, an evolving disease. J. Neurovirol. 9(2), 205-221.
53. Messam CA and EO Major (2000) Stages of restricted HIV-1 infection in astrocyte cultures derived from human fetal brain tissue. J. Neurovirol. 6(Suppl. 1), S90-S94.
54. Messam CA, J Hou, RM Gronostajski and EO Major (2003) Lineage pathway of human brain progenitor cells identified by JC virus susceptibility. Ann. Neurol. 53, 636-646.
55. Meucci O, A Fatatis, AA Simen, TJ Bushell, PW Gray and RJ Miller (1998) Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc. Natl. Acad. Sci. USA 95, 14500-14505.
56. Mukhtar M and RJ Pomerantz (2000) Development of an in vitro blood-brain barrier model to study molecular neuropathogenesis and neurovirologic disorders induced by human immunodeficiency virus type 1 infection. J. Hum. Virol. 3, 324-334.
57. Navia BA, ES Cho, CK Petito and RW Price (1986) The AIDS dementia complex, II. Neuropathology. Ann. Neurol. 19(6), 525-535.
58. Neuenburg JK, HR Brodt, BG Herndier, M Bickel, P Bacchetti, RW Price, RM Grant and W Schlote (2002) HIV-related neuropathology, 1985 to 1999, rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 31(2), 171-177.
59. Neumann M, BK Felber, A Kleinschmidt, B Froese, V Erfle, GN Pavlakis and R Brack-Werner (1995) Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function. J. Virol. 69(4), 2159-2167.
60. Ni HT, S Hu, WS Sheng, JM Olson, MC-J Cheeran, ASH Chan, JR Lokensgard and PK Peterson (2004) High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Dev. Brain Res. 152, 159-169.
61. Peng H, Y Huang, J Rose, D Erichsen, S Herek, N Fujii, H Tamamura and HJ Zhang (2004) Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. J. Neurosci. Res. 76, 35-50.
62. Perez A, AW Probert, KK Wang and L Sharmeen (2001) Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture. J. Neurovirol. 7, 1-10.
63. Persidsky Y and HE Gendelman (1997) Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia. J. Leukoc. Biol. 62, 100-106.
64. Powderly WG (2000) Current approaches to treatment for HIV-1 infection. J. Neurovirol. 6(Suppl. 1), S8-S13.
65. Price RW, BA Navia and ES Cho (1986) AIDS encephalopathy. Neurol. Clin. 4, 285-301.
66. Sabri F, E Tresoldi, M DeStefano, S Polo, MC Monaco, A Verani, JR Fiore, P Lusso, E Major, F Chiodi and G Scarlatti (1999) Nonproductive human immunodeficiency virus type 1 infection of human fetal astrocytes, independence from CD4 and major chemokine receptors. Virology 264(2), 370-384.
67. Sacktor N (2002) The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. J. Neurovirol. 8(Suppl. 2), 115-121.
68. Sacktor N, MP McDermott, K Marder, G Schifitto, OA Seines, JC McArthur, Y Stern, S Albert, D Palumbo, K Kieburtz, JA De Marcaida, B Cohen and L Epstein (2002) HIV-associated cognitive impairment before and after the advent of combination therapy. J. Neurovirol. 8 (2), 136-142.
69. Saito Y, LR Sharer, LG Epstein, J Michaels, M Mintz, M Louder, K Golding, TA Cvetkovich and BM Blumberg (1994) Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 44(3, Pt. 1), 474-481.
70. Sharer LR, Y Saito, LG Epstein and BM Blumberg (1994) Detection of HIV-1 DNA in pediatric AIDS brain tissue by twostep ISPCR. Adv. Neuroimmunol. 4 (3), 283-285.
71. Sharer LR, Y Saito, A Da Cunha, PC Ung, HA Gelbard, LG Epstein and BM Blumberg (1996) In situ amplification and detection of HIV-1 DNA in fixed pediatric AIDS brain tissue. Hum. Pathol. 27(6), 614-617.
72. Si Q, M Cosenza, H Goldstein and SC Lee (2002) GM-CSF and M-CSF modulate beta-chemokine and HIV-1 expression in microglia. Glia 39(2), 174-183.
73. Speth C, B Joebstl, M Barcova and MP Dierich (2000) HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. Aids 14(6), 629-636.
74. Speth C, MP Dierich and S Sopper (2005) HIV-infection of the central nervous system, the tightrope walk of innate immunity. Mol. Immunol. 42(2), 213-228.
75. Stern Y (1991) The impact of human immunodeficiency virus on cognitive function. Ann. NY Acad. Sci. 640, 219-223.
76. Svendsen CN, MG ter Borg, RJ Armstrong, AE Rosser, S Chandran, T Ostenfeld and MA Caldwell (1998) A new method for the rapid and long term growth of human neural precursor cells. J. Neurosci. Methods 85, 141-152.
77. Thompson KA, MJ Churchill, PR Gorry, J Sterjovski, RB Oelrichs, SL Wesselingh and CA McLean (2004) Astrocyte specific viral strains in HIV dementia. Ann. Neurol. 56(6), 873-877.
78. Tornatore C, R Chandra, JR Berger and EO Major (1994) HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44(3, Pt. 1), 481-487.
79. Torres-Munoz J, P Stockton, N Tacoronte, B Roberts, RR Maronpot and CK Petito (2001) Detection of HIV-1 gene sequences in hippocampal neurons isolated from postmortem AIDS brains by laser capture microdissection. J. Neuropathol. Exp. Neurol. 60(9), 885-892.
80. Trillo-Pazos G, A Diamanturos, L Rislove, T Menza, W Chao, P Belem, S Sadiq, S Morgello, L Sharer and DJ Volsky (2003) Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection. Brain Pathol. 13(2), 144-154.
81. Tuaillon N and CC Chan (2001) Molecular analysis of primary central nervous system and primary intraocular lymphomas. Curr. Mol. Med. 1, 259-272.
82. Vallat AV, U DeGirolam, J He, A Mhashilkar, W Marasco, B Shi, F Gray, J Bell, C Keohane, TW Smith et al. (1998) Localization of HIV-1 coreceptors CCR5 and CXCR4 in the brain of children with AIDS. Am. J. Pathol. 152, 167-178.
83. Wang Z, G Trillo-Pazos, SY Kim, M Canki, S Morgello, LR Sharer, HA Gelbard, ZZ Su, DC Kang, AI Brooks, PB Fisher and DJ Volsky (2004) Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function, potential role in neuropathogenesis. J. Neurovirol. 10(Suppl. 1), 25-32.
84. Weiss JM, A Nath, EO Major and JW Berman (1999) HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes. J. Immunol. 163(5), 2953-2959.
85. Wiley CA (2003) Detection of HIV-1 DNA in microglia/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection. Brain Pathol. 13(3), 415; author reply 415-6.
86. Wiley CA, RD Schrier, JA Nelson, PW Lampert and MB Oldstone (1986) Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc. Natl. Acad. Sci. USA 83, 7089-7093.
87. Wu DT, SE Woodman, JM Weiss, CM McManus, TG D'Aversa, J Hesselgesser, EO Major, A Nath and JW Berman (2000) Mechanisms of leukocyte trafficking into the CNS. J. Neurovirol. 6(Suppl. 1), S82-S85.
88. Zeichner SL, G Hirka, PW Andrews and JC Alwine (1992) Differentiation-dependent human immunodeficiency virus long terminal repeat regulatory elements active in human teratocarcinoma cells. J. Virol. 66(4), 2268-2273.