A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 Tat in vitro

AIDS

Volumn 13, Issue 12, 1999, Pages 1443-1452

  Brana, Corrine ^a   Biggs, Thelma E ^a   Barton, C Howard ^a   Sundstrom, Lars E ^a   Mann, Derek A ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

HIV 1 Tat; Neurotoxicity; Organotypic hippocampal cultures; RAW264.7 macrophages

Indexed keywords

CELL PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; PROPIDIUM IODIDE; RECOMBINANT PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DEATH; CELL DEGENERATION; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MACROPHAGE; MOUSE; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL LINE; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; GENE PRODUCTS, TAT; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; HIV-1; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICE; MICROTUBULE-ASSOCIATED PROTEINS; NEUROTOXINS; ORGAN CULTURE TECHNIQUES; RATS; RECOMBINANT PROTEINS;

EID: 0032869833     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199908200-00002     Document Type: Article

References (45)

1. Everall IP, Lanthos P. The Neuropathology of HIV: A review of the first 10 years. Int Rev Psychiatr 1991, 3:1119-1120.
2. Everall IP, Luthert PJ, Lanthos P. Neuronal loss in frontal cortex in HIV infection. Lancet 1991, 337:1119-1121.
3. Masliah E, Ge N, Achim CL, DeTeresa R, Wiley CA. Patterns of neurodegeneration. NeuroAIDS 1996, 1:161-173.
4. Tornatore C, Chandra R, Berger JR, Major FO. HIV infection of subcortical astrocytes in the paediatric CNS. Neurology 1994, 44:481-487.
5. Bagasra O, Lavi E, Bobroski L, et al. Cellular reservoirs of HIV-1 in the CNS of infected individuals identification by the combination of in situ polymerase chain reaction and immunohistochemistry. AIDS 1996, 10:573-585.
6. Wiley C, Shrier RD, Nelson JA, Lampert PW, Oldstone MBA. Cellular localization of human immodeficiency virus infection within the brains of acquired immunodeficiency syndrome patients. Proc Natl Acad Sci USA 1986, 83:70089-70093.
7. Nath A, Geiger JD. Neurobiological aspects of human immunodeficiency virus infection: neurotoxic mechanisms. Prog Neurobiol 1998, 54:19-33.
8. Magnuson DSK, Knudsen BE, Geiger JD, Brownstone RM, Nath A. Human immunodeficiency virus type 1 Tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995, 37:373-380.
9. Wu P, Price P, Du B, Hatch WC, Terwilliger EF. Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. Neuroreport 1996, 7:1045-1049.
10. Cheng J, Nath A, Knudsen B, et al. Neuronal excitatory properties of human immunodeficiency virus type 1 TAT protein. Neuroscience 1998, 82:97-106.
11. Sabatier JM, Vives E, Mabrouk K, et al. Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. J Virol 1991, 65: 961-967.
12. Philippon V, Vellutini C, Gambarelli D, et al. The basic domain of the lentiviral Tat Protein is responsible for damages in mouse brain: Involvement of cytokines. Virology 1994, 205:519-529.
13. Ensoli B, Buonaguro L, Barilari G. Release uptake and effects of extracellular HIV-1 Tat protein on cell growth in viral transactivation. J Virol 1993, 67:277-287.
14. Westendorp OP, Frank R, Ochsenbauer C, et al. Sensitisation of T-cells to CD95-mediated apoptosis by HIV-1 Tat and GP120. Nature 1995, 1995, 375:497-500.
15. Wesselingh SL, Power C, Glass JD, et al. Intracerebral cytokine messenger RNA expression in aquired immunodeficiency syndrome dementia. Ann Neurol 1993, 33:576-582.
16. Hofman FM, Dohadwala MM, Wright AD, Hinton DR, Walker SM. Exogenous Tat protein activated central nervous system-derived endothelial cells. J Neuroimmunol 1994, 54, 19-28.
17. Weeks BS, Lieberman DM, Johnson B, et al. Neurotoxicity of the human immunodeficiency virus type 1 tat transactivator to PC12 cells requires the Tat amino acid 49-58 basic domain. J Neurosci Res 1995, 42,34-40.
18. Jones M, Olafson K, Del Bigio MR, Peeling J, Nath A. Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement. J Neuropathol Exp Neurol 1998, 57:563-570.
19. Gahwiler BH, Capogna M, Debanne D, McKinney RA, Thompson SM. Organotypic slice cultures: a technique has come of age. Trends Neurosci 1997, 20:471-477.
20. Raschke WC, Baird S, Ralph R, Nakoinz I. Functional macrophage cell lines transformed by Abelson leukemia virus. 1978, Cell 15,261-267.
21. Stoppini L, Buchs PA, Muller D. A simple method for organotypic cultures of the nervous system. J Neurosci Methods 1991, 37:173-182.
22. Barton CH, Biggs IE, Mee IR, Mann DA. The HIV-1 regulatory protein Tat inhibits interferon-induced i-Nos activity in a murine macrophage cell line. J Gen Virol 1996, 77:1643-1647.
23. Cooke SJ, Coates K, Barton CH, et al. Regulated expression-vectors demonstrate cell-type-specific sensitivity to HIV-1 Nef-induced cytostasis. J Gen Virol 1997, 78:381-392.
24. Vornov JJ, Tasker R, Coyle JI. Direct observation of the agonist specific regional vulnerability to glutamate. NMDA and kainate neurotoxicity in organotypic hippocampal cultures. Exp Neurol 1991, 114,11-22.
25. Pringle AK, Iannoti F, Wilde GJC, Chad JE, Seeley PJ, Sundstrom LE. Neuroprotection by both NMDA and non-NMDA receptor antagonists in in vitro ischemia. Brain Res 1997, 755, 36-46.
26. Pringle AK, Benham CD, Sim L, Kennedy J, Iannoti F, Sundstrom LE. Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures. Stroke 1996, 27:2124-2130.
27. Wilde GJC, Pringle AK, Wright P, Iannotti F. Differential vulnerability of the CA1 and CA3 subfields of the hippocampus to superoxide and hydroxyl radicals in vitro. J Neurochem 1997, 69:883-886.
28. Magnuson DSK, Knudsen BF, Geiger JD, Brownstone RM, Nath A. Human immunodeficiency virus type 1 Tat activates Non-N-Methyl-D-Aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995, 37:373-380.
29. Strijbos PJLM, Zamani MR, Rothwell NJ, Arbuthnott C, Harkiss G. Neurotoxic mechanisms of transactivating protein Tat of Maedi-Visna virus. Neurosci Lett 1995, 197:215-218.
30. Nath A, Psooy K, Martin C, et al. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 1996, 70:1475-1480.
31. Pulliam L, Herndier BG, Tang NM, McGrath MS. Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest 1991, 87:503-512.
32. Lipton SA. Neuronal injury associated with HIV-1: Approaches to treatment. Annu Rev Pharmacol Toxicol 1998, 38:159-177.
33. Gibellini D, Zauli G, Re MC, et al. Recombinant human immunodeficiency virus type-1 (HIV-1) Tat protein sequentially up-regulates IL-6 and TGF-β mRNA expression and protein synthesis in peripheral blood monocytes. Br J Haematol 1994, 88:261-267.
34. Lafrenie RM, Wahl LM, Epstein JS, Hewlett IK, Yamada KM, Dhawan S. HIV-1 Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. J Immunol 1996, 156:1638-1645.
35. Lafrenie RM, Wahl LM, Epstein JS, Yamada KM, Dhawan S. Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression. J Immunol 1997, 159:4077-4083.
36. Gelbard HA, Dzenco KA, Diloreto D, Delcerro C, Delcerro M, Epstein LG. Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: Implication for AIDS neuropathogenesis. Dev Neurosci 1993, 15:417-422.
37. New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA. HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by NfkappaB-independent mechanism. J Biol Chem 1998, 273:17852-17858.
38. Wilde GJC, Pringle AK, Sundstrom, IE, Iannotti F. The protective effects of tumor necrosis factor in an in-vitro model of transient global ischaemia. J Neurol Neurosurg Psychiatry 1996, 60:241.
39. Flatch R, Schade FU. Peritoneal macrophages from endotoxin-tolerant mice produce an inhibitor of tumor necrosis factor alpha synthesis and protect against endotoxin shock. J Endotoxin Res 1997, 4:241-250.
40. Williams JG, Bernstein S, Prager M. Effect of melatonin on activated macrophage TNF, IL6 and reactive oxygen intermediates. Shock 1998, 9:406-411.
41. Godambe SA, Chaplin DD, Takova T, Read LM. Bellone CJ. A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1-βgene. Mol Cell Biol 1995, 15:112-119.
42. Espey MG, Chernyshev JF, Reinhard Jr, JF, Namboodiri MAA, Colton CA. Activated human microglia produce the excitotoxin quinolinic acid. Neuro Report 1997, 8:431-434.
43. Pemberton LA, Kerr SJ, Smythe G, Brew BJ. Quinolinic acid production by macrophages stimulated with IFN-γ, TNF-α and IFN-α. J Interteron Cytokine Res 1997, 17:589-595.
44. Kerr SJ, Armati PJ, Guillemin GJ, Brew BJ. Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex. AIDS 1998, 12:355-363.
45. Noack H, Lindenau J, Rothe F, Asayama K, Wolf G. Differential expression of superoxide dismutase isoforms in neuronal and glial compartments in the course of excitotoxically mediated neurodegeneration: relation to oxidative and nitrergic stress. Glia 1998, 23:285-297.