Loss of the surface antigen 3G11 characterizes a distinct population of allergic/regulatory T cells in experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 176, Issue 6, 2006, Pages 3366-3373

  Zhang, Guang Xian ^a   Yu, Shuo ^a   Calida, Divina ^a   Zhao, Zhao ^a   Gran, Bruno ^a   Kamoun, Malek ^b   Rostami, Abdolmohamad ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; LYMPHOCYTE SURFACE MARKER; MEMBRANE ANTIGEN; MYELIN BASIC PROTEIN; SURFACE ANTIGEN 3G11; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SURFACE; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 33644833614     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.6.3366     Document Type: Article

References (47)

1. Hohlfeld, R. 1997. Biotechnological agents for the immunotherapy of multiple sclerosis: principles, problems and perspectives. Brain 120: 865-916.
2. Hafler, D. A., J. M. Slavik, D. E. Anderson, K. C. O'Connor, P. De Jager, and C. Baecher-Allan. 2005. Multiple sclerosis. Immunol. Rev. 204: 208-231.
3. Whitacre, C. C., I. E. Gienapp, C. G. Orosz, and D. M. Bitar. 1991. Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy. J. Immunol. 147: 2155-2163.
4. Weiner, H. L., A. Friedman, A. Miller, S. J. Khoury, A. al-Sabbagh, L. Santos, M. Sayegh, R. B. Nussenblatt, D. E. Trentham, and D. A. Hafler. 1994. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol 12: 809-837.
5. Kumar, V. 2004. Homeostatic control of immunity by TCR peptide-specific Tregs. J. Clin. Invest. 114: 1222-1226.
6. Taylor, N., K. McConnachie, C. Calder, R. Dawson, A. Dick, J. D. Sedgwick, and J. Liversidge. 2005. Enhanced tolerance to autoimmune uveitis in CD200-deficient mice correlates with a pronounced Th2 switch in response to antigen challenge. J. Immunol. 174: 143-154.
7. Schwartz, R. H. 2003. T cell anergy. Annu. Rev. Immunol. 21: 305-334.
8. Macian, F., S. H. Im, F. J. Garcia-Cozar, and A. Rao. 2004. T-cell anergy. Curr. Opin. Immunol. 16: 209-216.
9. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79: 913-922.
10. Korb, L. C., S. Mirshahidi, K. Ramyar, A. A. Sadighi Akha, and S. Sadegh-Nasseri. 1999. Induction of T cell anergy by low numbers of agonist ligands. J. Immunol. 162: 6401-6409.
11. Jeon, M. S., A. Atfield, K. Venuprasad, C. Krawczyk, R. Sarao, C. Elly, C. Yang, S. Arya, K. Bachmaier, L. Su, et al. 2004. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21: 167-177.
12. van Parijs, L., V. L. Perez, and A. K. Abbas. 1998. Mechanisms of peripheral T cell tolerance. Novartis Found. Symp. 215: 5-14.
13. Mueller, D. L., and M. K. Jenkins. 1995. Molecular mechanisms underlying functional T-cell unresponsiveness. Curr. Opin. Immunol. 1: 375-381.
14. Nelson, B. H. 2002. Interleukin-2 signaling and the maintenance of self-tolerance. Curr. Dir. Autoimmun. 5: 92-112.
15. Maier, C. C., A. Bhandoola, W. Borden, K. Yui, K. Hayakawa, and M. I. Greene. 1998. Unique molecular surface features of in vivo tolerized T cells. Proc. Natl. Acad. Sci. USA 95: 4499-4503.
16. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400.
17. Cassis, L., S. Aiello, and M. Noris. 2005. Natural versus adaptive regulatory T cells. Contrib. Nephrol. 146: 121-131.
18. Burkhart, C., G. Y. Liu, S. M. Anderton, B. Metzler, and D. C. Wraith. 1999. Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int. Immunol. 11: 1625-1634.
19. Sundstedt, A., E. J. O'Neill, K. S. Nicolson, and D. C. Wraith. 2003. Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J. Immunol. 170: 1240-1248.
20. + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp, Med. 197: 111-119.
21. Moore, K. W., R. de Waal Malefyt, R. L. Coffman, and A. O'Garra. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19: 683-765.
22. + T cell subsets defined. J. Exp. Med. 168: 1825-1838.
23. Dittrich, F., K. Hayakawa, M. Nimtz, F. Ebel, and P. F. Muhlradt. 1994. Identification of the mouse helper T lymphocyte differentiation antigen 3G11 as the ganglioside IV3(NeuAc)2-GgOse4Cer. Biochem. Biophys. Res. Commun. 200: 1557-1563.
24. Kuchroo, V. K., A. C. Anderson, H. Waldner, M. Munder, E. Bettelli, and L. B. Nicholson. 2002. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 20: 101-123.
25. Sorensen, P. S. 2005. Multiple sclerosis: pathophysiology revisited. Lancet Neurol. 4: 9-10.
26. Dittel, B. N., R. M. Merchant, and C. A. Janeway, Jr. 1999. Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis. J. Immunol. 162: 6392-6400.
27. Critchfield, J. M., M. K. Racke, J. C. Zuniga-Pflucker, B. Cannella, C. S. Raine, J. Goverman, and M. J. Lenardo. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263: 1139-1143.
28. Zhang, G. X., H. Xu, M. Kishi, D. Calida, and A. Rostami. 2002. The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. J. Immunol. 168: 2501-2507.
29. Zhang, G. X., S. Yu, Y. Li, E. S. Ventura, B. Gran, and A. Rostami. 2005. A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 161: 101-112.
30. Ferguson, T. A., P. M. Stuart, J. M. Herndon, and T. S. Griffith. 2003. Apoptosis, tolerance, and regulatory T cells-old wine, new wineskins. Immunol. Rev. 193: 111-123.
31. Gaur, A., B. Wiers, A. Liu, J. Rothbard, and C. G. Fathman. 1992. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 258: 1491-1494.
32. Hilliard, B. A., M. Kamoun, E. Ventura, and A. Rostami. 2000. Mechanisms of suppression of experimental autoimmune encephalomyelitis by intravenous administration of myelin basic protein: role of regulatory spleen cells. Exp. Mol. Pathol. 68: 29-37.
33. + T cell anergy in vitro. J. Exp. Med. 187: 89-96.
34. Wells, A. D., M. C. Walsh, J. A. Bluestone, and L. A. Turka. 2001. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J. Clin. Invest. 108: 895-903.
35. Perez, V. L., L. Van Parijs, A. Biuckians, X. X. Zheng, T. B. Strom, and A. K. Abbas. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6: 411-417.
36. + T cell anergy in vivo. J. Immunol. 167: 4936-4941.
37. Sundstedt, A., I. Hoiden, A. Rosendahl, T. Kalland, N. van Rooijen, and M. Dohlsten. 1997. Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo. J. Immunol. 158: 180-186.
38. Buer, J., A. Lanoue, A. Franzke, C. Garcia, H. von Boehmer, and A. Sarukhan. 1998. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J. Exp. Med. 187: 177-183.
39. Mana, P., M. Goodyear, C. Bernard, R. Tomioka, M. Freire-Garabal, and D. Linares. 2004. Tolerance induction by molecular mimicry: prevention and suppression of experimental autoimmune encephalomyelitis with the milk protein butyrophilin. Int. Immunol. 16: 489-499.
40. + cell subsets in mice as revealed by single-cell cytokine analysis. Eur. J. Immunol. 24: 549-557.
41. Lombardi, G., R. Hargreaves, S. Sidhu, N. Imami, L. Lightstone, S. Fuller-Espie, M. Ritter, P. Robinson, A. Tarnok, and R. Lechler. 1996. Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals. J. Immunol. 156: 2769-2775.
42. + T lymphocytes. Immunol. Today 9: 268-274.
43. Gajewski, T. F., D. W. Lancki, R. Stack, and F. W. Fitch. 1994. "Anergy" of Th0 helper T lymphocytes induces downregulation of Th1 characteristics and a transition to a Th2-like phenotype. J. Exp. Med. 179: 481-491.
44. Maeda, H., S. Fujimoto, and M. I. Greene. 2000. Suppressor T cells regulate the nonanergic cell population that remains after peripheral tolerance is induced to the Mls-1 antigen in T cell receptor Vβ8.1 transgenic mice. Proc. Natl. Acad. Sci. USA 97: 13257-13262.
45. Chen, T. C., S. P. Cobbold, P. J. Fairchild, and H. Waldmann. 2004. Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen. J. Immunol. 172: 5900-5907.
46. + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 101: 15434-15439.
47. + T cells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 17: 279-288.