Mechanisms of suppression of experimental autoimmune encephalomyelitis by intravenous administration of myelin basic protein: Role of regulatory spleen cells

Experimental and Molecular Pathology

Volumn 68, Issue 1, 2000, Pages 29-37

  Hilliard, Brendan A ^a   Kamoun, Malek ^a   Ventura, Elvira ^a   Rostami, Abdolmohamad ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Experimental allergic encephalomyelitis; Intravenous; Myelin basic protein; Spleen cells; Tolerance

Indexed keywords

MYELIN BASIC PROTEIN;

ACTIVE IMMUNIZATION; ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; LYMPH NODE CELL; NONHUMAN; RAT; SPLEEN CELL; T LYMPHOCYTE;

ANIMALIA;

EID: 0033974682     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1006/exmp.1999.2290     Document Type: Article

References (38)

1. Al-Sabbagh A., Miller A., Weiner H. L. Suppression of EAE by oral and intravenous myelin basic protein, and by T-cell receptor peptide prior to or following disease expression. Neurology. 43:1993;A411.
2. Austyn J. M., Kupiec-Weglinski J. W., Hankins D. F., Morris P. J. Migration patterns of dendritic cells in the mouse: Homing to T cell-dependent areas of spleen, and binding within marginal zone. J. Exp. Med. 167:1988;646-651.
3. Bauer J., Berkenbosch F., Van Dam A. M., Dijkstra C. D. Demonstration of interleukin-1 beta in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level. J. Neuroimmunol. 48:1993;13-21.
4. Beverly B., Kang S.-M., Lenardo M. J., Schwartz R. H. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 4:1992;661-671.
5. Chabannes D., Borel J. F. Suppressor cells of popliteal lymph node origin are involved in the in vivo and in vitro control of experimental allergic encephalomyelitis effector cells in the Lewis rat. Eur. J. Immunol. 21:1991;731-736.
6. Chen C., Nabavi N. In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2. Immunity. 1:1994;147-154.
7. + cell mediate active suppression. J. Immunol. 155:1995;910-916.
8. Chen Y., Kuchroo V. K., Inobe J., Hafler D. A., Weiner H. L. Regulatory T cells induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Science. 265:1994;1237-1240.
9. Condie R. M., Monson R., Good R. A. Prevention of experimental allergic encephalomyelitis. Fed. Proc. 18:1959;563.
10. Critchfield J. M., Racke M. K., Zuniga-Pflucker J. C., Cannela B., Raine C., Goverman J., Lenardo M. J. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science. 263:1994;1139-1143.
11. Deibler D. E., Martenson R. E., Keyes M. W. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep. Biochem. 2:1972;139-165.
12. Gaur A., Wiers B., Liu A., Rothbad J., Fathman C. G. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science. 258:1992;1491-1494.
13. Harling-Berg C. J., Knopf P. M., Cserr H. F. Myelin basic protein infused into cerobrospinal fluid suppresses experimental autoimmune encephalomyelitis. J. Neuroimmunol. 35:1991;45-51.
14. Higgins P. J., Weiner H. L. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J. Immunol. 140:1988;440-445.
15. Hilliard B., Ventura E. S., Rostami A. Effect of timing of intravenous administration of myelin basic protein on the induction of tolerance in experimental allergic encephalomyelitis. Multiple Sclerosis. 5:1999;2-9.
16. Issazadeh S., Mustafa M., Ljungdahl A., Hojeberg B., Dagerlind A., Elde R. Interferon-γ, interleukin-4 and transforming growth factor-β in experimental autoimmune encephalomyelitis in Lewis rats: Dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J. Neurosci.Res. 40:1995;579-590.
17. Kabelitz D., Pohl T., Pechhold K. Activation induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol. Today. 14:1993;338-339.
18. Kang S.-M., Beverly B., Tran A.-C., Brorson K., Schwartz R. H., Lenardo M. J. Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science. 257:1992;1134-1138.
19. Karin N., Mitchell D. J., Brocke S., Ling N., Steinmann L. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon γ and tumor necrosis factor α production. J. Exp. Med. 180:1994;2227-2237.
20. + suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-β J. Immunol. 146:1991;1163-1168.
21. Kennedy M. K., Dal Canto M. C., Trotter J. L., Miller S. D. Specific immune regulation of chronic-relapsing experimental allergic encephalomyelitis in mice. J. Immunol. 141:1988;2986-2993.
22. Kennedy M. K., Torrance D. S., Picha K. S., Mohler K. M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:1992.
23. Kies M. W., Shaw C. M., Fahlberg W. J., Alvord E. C. Factors affecting the suppression allergic encephalomyelitis by homologous brain protein fractions. Ann. Allergy. 18:1960;849.
24. Levine S., Hoenig E. M., Kies M. W. Allergic encephalomyelitis: Passive transfer prevented by encephalitogen. Science. 161:1968;1155-1157.
25. Levine S., Hoenig E. M., Kies M. W. Allergic encephalomyelitis: Immunologically specific inhibition of cellular passive transfer by encephalitogenic basic proteins. Clin. Exp. Immunol. 6:1970;503-517.
26. Martin R., McFarland H. F., McFarlin D. E. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:1992;153-157.
27. Miller A., Hafler D. A., Weiner H. L. Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: Implications for immunotherapy of human autoimmune diseases. FASEB. 5:1991;2560-2566.
28. Miller S. D., Tan L. J., Pope L., McRae L., Karpus W. J. Antigen-specific tolerance as a therapy for experimental autoimmune encephalomyelitis. Intern. Rev. Immunol. 9:1992;203-222.
29. Paterson P. Y., Swanborg R. H. Samter M., Talmage D. W., Frank M. M., Austen K. F., Claman H. N. Immunological Diseases. 1988;Little, Brown, Boston/Toronto.
30. Pope L., Paterson P. Y., Miller S. D. Antigen-specific inhibition of the adoptive transfer of experimental autoimmune encephalomyelitis in Lewis rats. J. Neuroimmunol. 37:1992;177-190.
31. Racke M. K., Bonomo A., Scott D. E., Cannella B., Levine A., Raine C. S., Shevach E., Rocken M. Cytokine induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1994;1961-1966.
32. Ridge J. P., Fuchs E. J., Matzinger P. Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells. Science. 271:1996;1723-1726.
33. Santambrogio L., Crisi G. M., Leu J., Hochwald G. M., Ryan T., Thorbecke G. J. Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis. J. Immunol. 58:1995;211-222.
34. Swierkosz J. E., Swanborg R. H. Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis. J. Immunol. 115:1975;631-633.
35. Swierkosz J. E., Swanborg R. H. Immunoregulation of experimental allergic encephalomyelitis: Conditions for induction of suppressor cells and analysis of mechanism. J. Immunol. 119:1977;1501-1506.
36. Tan L.-J., Kennedy M. K., Dal Canto M. C., Miller S. D. Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance. J. Immunol. 147:1991;1797-1802.
37. Vandenbark A. A., Celnik B., Vainiene M., Miller S. D., Offner H. Myelin antigen-coupled splenocytes suppress experimental autoimmune encephalomyelitis in Lewis rats through a partially reversible anergy mechanism. J. Immunol. 155:1995;5861-5867.
38. Whitacre C. C., Gienapp I. E., Orosz C. G., Bitar D. M. Oral tolerance in experimental autoimmune encephalomyelitis III: Evidence for clonal anergy. J. Immunol. 147:1991;2155-2163.