Role of peroxisome proliferator-activated receptor gamma in glucose-induced insulin secretion

Acta Biochimica et Biophysica Sinica

Volumn 38, Issue 1, 2006, Pages 1-7

  Xu, Ze Kuan ^a   Chen, Neng Guin ^a   Ma, Chang Yan ^a   Meng, Zhuo Xian ^a   Sun, Yu Jie ^a   Han, Xiao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cb1 associated; Glucose transporter 2; Glucose induced insulin secretion; Ligand; PPAR

Indexed keywords

GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL; ARTICLE; DOSE RESPONSE; GENE TARGETING; GENETICS; INSULINOMA; METABOLISM; METHODOLOGY; RAT; SECRETION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE TARGETING; GLUCOSE; INSULIN; INSULINOMA; PPAR ALPHA; PPAR GAMMA; RATS;

EID: 33644832527     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2006.00128.x     Document Type: Article

References (45)

1. Mangelsdorf DJ Evans RM. The RXR heterodimers and orphan receptors Cell 1995 83 841 850
2. Forman BM Samuel HH. Interactions among a subfamily of nuclear hormone receptors: The regulatory zipper model Mol Endocrinol 1990 4 1293 1301
3. Chakravarti D LaMorte VJ Nelson MC Nakajima T Schulman IG Juguilon H Montminy M et al. Role of CBP/P300 in nuclear receptor signaling Nature 1996 383 99 103
4. Hu E Kim JB Sarraf P Spiegelman BM. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR Science 1996 274 2100 2103
5. Camp HS Tafuri SR Leff T. c-Jun N-terminal kinase phosphorylates peroxi-some proliferator-activated receptor-gamma 1 and negatively regulates its trans crip tional activity Endocrinology 1999 140 392 397
6. Adams M Reginato MJ Shao D Lazar MA Chatterjee VK. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site J Biol Chem 1997 272 5128 5132
7. Shao D Lazar MA. Modulating nuclear receptor function: May the phos be with you J Clin Invest 1999 103 1617 1618
8. Saltiel AR Olefsky JM. Thiazolidinediones in the treatment of insulin resistance and type II diabetes Diabetes 1996 45 1661 1669
9. Maggs DG Buchanan TA Burant CF Cline G Gumbiner B Hsueh WA Inzucchi S et al. Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. Arandomized, double-blind, placebo-controlled trial Ann Intern Med 1998 128 176 185
10. Forman BM Tontonoz P Chen J Brun RP Spiegelman BM Evans RM. 15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell 1995 83 803 812
11. Kliewer SA Lenhard JM Willson TM Patel I Morris DC Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation Cell 1995 83 813 819
12. Willson TM Cobb JE Cowan DJ Wiethe RW Correa ID Prakash SR Beck KD et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones J Med Chem 1996 39 665 668
13. Lehmann JM Moore LB Smith-Oliver TA Wilkison WO Willson TM Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARγ) J Biol Chem 1995 270 12953 12956
14. Spiegelman BM. PPAR-γ: Adipogenic regulator and thiazolidinedione receptor Diabetes 1998 47 507 514
15. Auwerx J. PPARγ, the ultimate thrifty gene Diabetologia 1999 42 1033 1049
16. Nugent C Prins JB Whitehead JP Wentworth JM Chatterjee VK O'Rahilly S. Arachidonic acid stimulates glucose uptake in 3T3-L1 adipocytes by increasing GLUT1 and GLUT4 levels at the plasma membrane. Evidence for involvement of lipoxygenase metabolites and peroxisome proliferator-activated receptor gamma J Biol Chem 2001 276 9149 9157
17. Yen CJ Beamer BA Negri C Silver K Brown KA Yarnall DP Burns DK et al. Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation Biochem Biophys Res Comm 1997 241 270 274
18. Deeb SS Fajas L Nemoto M Pihlajamaki J Mykkanen L Kuusisto J Laakso M et al. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity Nat Genet 1998 20 284 287
19. Ristow M Muller-Wieland D Pfeiffer A Krone W Kahn CR. Obesity associated with a mutation in a genetic regulator of adipose differentiation N Engl J Med 1998 339 953 959
20. Barroso I Gurnell M Crowley VE Agostini M Schwabe JW Soos MA Maslen GL et al. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension Nature 1999 402 880 883
21. Ek J Andersen G Urhammer SA Gaede PH Drivsholm T Borch-Johnsen K Hansen T et al. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus Diabetologia 2001 44 2220 2226
22. Unger RH. Diabetic hyperglycemia: Link to impaired glucose transport in pancreatic beta cells Science 1991 251 1200 1205
23. Higa M Zhou YT Ravazzola M Baetens D Orca L Unger RH. Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats Proc Natl Acad Sci USA 1999 96 11513 11518
24. Kim HI Kim JW Kim SH Cha JY Kim KS Ahn YH. Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter Diabetes 2000 49 1517 1524
25. Chen NG Sarabia SF Malloy PJ Zhao XY Feldman D Reaven GM. PPARγ agonists enhance human vascular endothelial adhesiveness by increasing ICAM-1 expression Biochem Biophys Res Comm 1999 263 718 722
26. Hohmeier HE Newgard CB. Cell lines derived from pancreatic islets Mol Cell Endocrinol 2004 228 121 128
27. Baumann CA Ribon V Kanzaki M Thurmond DC Mora S Shigematsu S Bickel PE et al. CAP defines a second signaling pathway required for insulin-stimulated glucose transport Nature 2000 407 202 207
28. Dubois M Pattou F Kerr-Conte J Gmyr V Vandewalle B Desreumaux P Auwerx J et al. Expression of peroxisome proliferator-activated receptor gamma (PPARγ) in normal human pancreatic islet cells Diabetologia 2000 43 1165 1169
29. Zhou YT Shimabukuro M Wang MY Lee Y Higa M Milburn JL Newgard CB et al. Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells Proc Natl Acad Sci USA 1998 95 8898 8903
30. Dillon JS Yaney GC Zhou Y Voilley N Bowen S Chipkin S Bliss CR et al. Dehydroepiandrosterone sulfate and beta-cell function: Enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells Diabetes 2000 49 2012 2020
31. Laybutt R Hasenkamp W Groff A Grey S Jonas JC Kaneto H Sharma A et al. Beta-cell adaptation to hyperglycemia Diabetes 2001 50 S180 S181
32. Toruner F Akbay E Cakir N Sancak B Elbeg S Taneri F Akturk M et al. Effects of PPARγ and PPARγ agonists on serum leptin levels in diet-induced obese rats Horm Metab Res 2004 36 226 230
33. Jia DM Otsuki M. Troglitazone stimulates pancreatic growth in normal rats Pancreas 2002 24 303 312
34. Harmon JS Gleason CE Tanaka Y Oseid EA Hunter-Berger KK Robertson RP. In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression Diabetes 1999 48 1995 2000
35. Schuit FC Huypens P Heimberg H Pipeleers DG. Glucose sensing in pancreatic beta-cells: Amodel for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus Diabetes 2001 50 1 11
36. Cuesta-Munoz AL Huopio H Otonkoski T Gomez-Zumaquero JM Nanto-Salonen K Rahier J Lopez-Enriquez S et al. Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation Diabetes 2004 53 2164 2168
37. Thorens B Guillam MT Beermann F Burcelin R Jaquet M. Transgenic reexpression of GLUT 1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion J Biol Chem 2000 275 23751 23758
38. Garvey WT. Glucose transport and NIDDM Diabetes Care 1992 15 396 417
39. Bonny C Thompson N Nicod P Waeber G. Pancreatic-specific expression of the glucose transporter type 2 gene: Identification of cis-elements and islet-specific trans-acting factors Mol Endocrinol 1995 9 1413 1426
40. Guillam MT Dupraz P Thorens B. Glucose uptake, utilization, and signaling in GLUT2-null islets Diabetes 2000 49 1485 1491
41. Leibiger B Leibiger IB Moede T Kemper S Kulkarni RN Kahn CR de Vargas LM et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells Mol Cell 2001 7 559 570
42. Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes Cell 2001 104 517 529
43. Ahn YH Yoon DJ Han GS Lee BG. Cloning and expression of rat liver type glucose transporter and translocation by insulin in Chinese hamster ovary cells Yonsei Med J 1993 34 117 125
44. Brant AM Martin S Gould GW. Expression of the liver-type glucose transporter (GLUT2) in 3T3-L1 adipocytes: Analysis of the effects of insulin on subcellular distribution Biochem J 1994 304 307 311
45. Roduit R Morin J Masse F Segall L Roche E Newgard CB Assimacopoulos- Jeannet F et al. Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta-cell J Biol Chem 2000 275 35799 35806