Diacylglycerol: Efficacy and mechanism of action of an anti-obesity agent

Obesity Research

Volumn 13, Issue 11, 2005, Pages 1864-1876

  Rudkowska, Iwona ^a   Roynette, Catherine E ^a   Demonty, Isabelle ^a   Vanstone, Catherine A ^a   Jew, Stephanie ^a   Jones, Peter J H ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Body composition; Body weight; Diacylglycerol; Serum triacylglycerol; oxidation

Indexed keywords

ANIMALIA;

ANTIOBESITY AGENT; DIACYLGLYCEROL; EDIBLE OIL; LIPID;

ANIMAL; BLOOD; BODY COMPOSITION; DRUG EFFECT; FEMALE; HUMAN; MALE; OBESITY; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; REVIEW; TREATMENT OUTCOME;

ANIMALS; ANTI-OBESITY AGENTS; BODY COMPOSITION; DIETARY FATS, UNSATURATED; DIGLYCERIDES; FEMALE; HUMANS; LIPIDS; MALE; OBESITY; OXIDATION-REDUCTION; TREATMENT OUTCOME;

EID: 33644821463     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2005.229     Document Type: Review

References (44)

1. Hedley AA, Ogden CL, Johnson CL, et al. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA. 2004;291:2847-50.
2. Akoh CC, Lipid-based fat substitutes. Crit Rev Food Sci Nutr. 1995;35:405-30.
3. Matsuo N, Tokimitsu I. Metabolic characteristics of diacylglycerol. Inform. 2001;12:1098-102.
4. Flickinger BD, Matsuo N. Nutritional characteristics of DAG oil. Lipids. 2003;38:129-32.
5. Takase H, Shoji K, Hase T, Tokimitsu I. Effect of diacylglycerol on postprandial lipid metabolism in non-diabetic subjects with and without insulin resistance. Atherosclerosis. 2005;180:197-204.
6. Yasunaga K, Gillnsmann WH, Seo Y, et al. Safety aspects regarding the consumption of high-dose dietary diacylglycerol oil in men and women in a double-blind controlled trial in comparison with consumption of a triacylglycerol control oil. Food Chem Toxicol. 2004;42:1419-29.
7. Watanabe H, Onizawa K, Taguchi H, et al. Nutritional characterization of diacylglycerols in rats. J Jpn Oil Chem Soc. 1997;46:301-7.
8. Murata M, Ide T, Hara K. Reciprocal responses to dietary diacylglycerol of hepatic enzymes of fatty acid synthesis and oxidation in the rat. Br J Nutr. 1997;77:107-21.
9. Murase T, Aoki M, Wakisaka T, Hase T, Tokimitsu I. Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism. J Lipid Res. 2002;43:1312-9.
10. Murase T, Nagasawa A, Suzuki J, et al. Dietary alphalinolenic acid-rich diacylglycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db mice. J Nutr. 2002;132:3018-22.
11. Meng X, Zou D, Shi Z, Duan Z, Mao Z. Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue. Lipids. 2004;39:37-41.
12. Sugimoto T, Kimura T, Fukuda H, Iritani N. Comparisons of glucose and lipid metabolism in rats fed diacylglycerol and triacylglycerol oils. J Nutr Sci Vitaminol. 2003;49:47-55.
13. Kamphuis MM, Mela DJ, Westerterp-Plantenga MS. Diacylglycerols affect substrate oxidation and appetite in humans. Am J Clin Nutr. 2003;77:1133-9.
14. Murase T, Mizuno T, Omachi T, et al. Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice. J Lipid Res. 2001;42:372-8.
15. Nagao T, Watanabe H, Goto N, et al. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J Nutr. 2000;130:792-7.
16. Maki KC, Davidson MH, Tsushima R, et al. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil. Am J Clin Nutr. 2002;76:1230-6.
17. Sugimoto T, Fukuda H, Kimura T, Iritani N. Dietary diacylglycerol-rich oil stimulation of glucose intolerance in genetically obese rats. J Nutr Sci Vitaminol. 2003;49:139-44.
18. Watanabe H, Nagao T, Yasukawa T, Shimasaki H. Studies on the role of dietary diacylglycerols in human nutrition. World Rev Nutr Diet. 2001;88:155-62.
19. Ross R. Advances in the application of imaging methods in applied and clinical physiology. Acta Diabetol. 2003;4:S45-50.
20. Yamamoto K, Askawa H, Tokunaga K, et al. Long-term ingestion of dietary diacylglycerol lowers serum triacylglycerol in type II diabetic patients with hypertriglyceridemia. J Nutr. 2001;131:3204-7.
21. Teramoto T, Watanabe H, Ito K, et al. Significant effects of diacylglycerol on body fat and lipid metabolism in patients on hemodialysis. Clin Nutr. 2004;23:1122-6.
22. Couillard C, Bergeron N, Prud'homme D, et al. Postprandial triglyceride response in visceral obesity in men. Diabetes. 1998;47:953-60.
23. Mekkl N, Christofilis MA, Charbonnier M, et al. Influence of obesity and body fat distribution on postprandial lipemia and triglyceride-rich lipoproteins in adult women. J Clin Endocrinol Metab. 1999;84:184-91.
24. Hara K, Onizawa K, Honda H, Otsuji K, Ide T, Murata M. Dietary diacylglycerol-dependent reduction in serum triacylglycerol concentration in rats. Ann Nutr Metab. 1993;37:185-91.
25. Murata M, Hara K, Ide T. Alteration by diacylglycerols of the transport and fatty acid composition of lymph chylomicrons in rats. Biosci Biotech Biochem. 1994;58:1416-9.
26. Kondo H, Hase T, Murase T, Tokimitsu I. Digestion and assimilation features of dietary DAG in the rat small intestine. Lipids. 2003;38:25-30.
27. Soni MG, Kimura H, Burdock GA. Chronic study of diacylglycerol oil in rats. Food Chem Toxicol. 2001;39:317-29.
28. Taguchi H, Omachi T, Nagao T, et al. Dietary diacylglycerol suppresses high fat diet-induced hepatic fat accumulation and microsomal triacylglycerol transfer protein activity in rats. J Nutr Biochem. 2002;13:678-83.
29. Meguro S, Hase T, Otsuka A, Tokimitsu I, Itakura H. Effect of phytosterols in dietary diacylglycerol on atherosclerosis in cholesterol-fed rabbits. Nutrition. 2003;19:670-5.
30. Katan MB, Grundy SM, Jones P, et al. Stresa Workshop Participants. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc. 2003;78:965-78.
31. Taguchi H, Watanabe H, Onizawa K, et al. Double-blind controlled study on the effects of dietary diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans. J Am Coll Nutr. 2000;19:789-96.
32. Tada N, Watanabe H, Matsuo N, Tokimitsu I, Okazaki M. Dynamics of postprandial remnant-like lipoprotein particles in serum after loading of diacylglycerols. Clinica Chimica Acta. 2001;311:109-17.
33. Yanagisawa Y, Kawabata T, Tanaka O, et al. Improvement in blood lipid levels by dietary sn-1,3-diacylglycerol in young women with variants of lipid transporters 54T-FABP2 and - 493g-MTP. Biochem Biophys Res Comm. 2003;302:743-50.
34. Yamamoto K, Asakawa H, Tokunaga K, et al. Effects of diacylglycerol administration on serum triacylglycerol in a patient homozygous for complete lipoprotein lipase deletion. Metabolism. 2005;54:67-71.
35. Meguro S, Higashi K, Hase T, et al. Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. Eur J Clin Nutr. 2001;55:513-7.
36. Patel A, Barzi F, Jamrozik K, et al. Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region. Circulation. 2004;110:2678-86.
37. Taguchi H, Nagao T, Watanabe H, et al. Energy value and digestibility of dietary oil containing mainly 1,3-diacylglycerol are similar to those of triacylglycerol. Lipids. 2001;36:379-82 Erratum in: Lipid. 2003;38:893.
38. Yang LY, Kuksis A. Apparent convergence (at 2-monoacylglycerol level) of phosphatidic acid and 2-monoacylglycerol pathways of synthesis of chylomicron triacylglycerols. J Lipid Res. 1991;32:1173-86.
39. Tada N. Physiological actions of diacylglycerol outcome. Curr Opin Clin Nutr Metab Care. 2004;7:145-9.
40. Westerterp-Plantenga MS. Fat intake and energy-balance effects. Physiol Behav. 2004;83:579-85.
41. Smith SJ, Cases S, Jensen DR, et al. Obesity resistance and multiple mechanisms of triglyceride synthesis and mice lacking Dgat. Nature Genetics. 2000;25:87-90.
42. Chen HC, Farese RV Jr. DGAT and triglyceride synthesis: a new target for obesity treatment? Trends Cardiovasc Med. 2000;10:188-92.
43. Watanabe H, Onizawa K, Naito S, et al. Fat-soluble vitamin status is not affected by diacylglycerol consumption. Ann Nutr Metab. 2001;45:259-64.
44. Kasamatsu T, Ogura R, Ikeda N, et al. Genotoxicity studies on dietary diacylglycerol (DAG) oil. Fond Chem Toxicol. 2005;43:253-60.