Using a speech perception neural network computer simulation to contrast neuroanatomic versus neuromodulatory models of auditory hallucinations

Pharmacopsychiatry

Volumn 39, Issue SUPPL. 1, 2006, Pages

  Hoffman, Ralph E ^a   McGlashan, T H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE;

ARTICLE; ARTIFICIAL NEURAL NETWORK; AUDITORY HALLUCINATION; BRAIN DEVELOPMENT; BRAIN FUNCTION; CLINICAL ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; FEMALE; HUMAN; HYPOTHESIS; MALE; MODEL; NEUROANATOMY; NEUROMODULATION; PHONETICS; PRIORITY JOURNAL; SCHIZOPHRENIA; SPEECH; SPEECH PERCEPTION; WORKING MEMORY;

ADOLESCENT; ADULT; BRAIN; COMPUTER SIMULATION; DOPAMINE; HALLUCINATIONS; HUMANS; MEMORY, SHORT-TERM; NEURAL NETWORKS (COMPUTER); NEUROTRANSMITTER AGENTS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SPEECH PERCEPTION; SYNAPSES;

EID: 33644818267     PISSN: 01763679     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-931496     Document Type: Article

References (71)

1. Aboitz F, Garcia R. The anatomy of language revisited. Biological Research 1997; 30: 171-83
2. Akil M, Edgar CL, Pierri JN, Casali S, Lewis DA. Decreased density of tyrosine hydroxylase-immunoreactive axons in the entorhinal cortex of schizophrenic subjects. Biological Psychiatry 2000; 47: 361-70
3. Akil M, Pierri JN, Whitehead RE, Edgar CL, Mohila C, Sampson AR, Lewis DA. Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects. American Journal of Psychiatry 1999; 156: 1580-9
4. Andreasen NC, Flaum M. Schizophrenia: The characteristic symptoms. Schizophrenia Bulletin 1991; 17(1): 27-49
5. Arnold SE. Cellular and molecular neuropathology of the parahippocampal region in schizophrenia. Annals of the New York Academy of Sciences. 2000; 911: 275-92
6. Blennow K, Bogdanovic N, Cottfries CG, Davidsson P. The growth-associated protein GAP-43 is increased in the hippocampus and in the gyrus cinguli in schizophrenia. Journal of Molecular Neuroscience 1999; 13: 101-9
7. Braff DL, Swerdlow NR, Geyer MA. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. American Journal of Psychiatry 1999; 156: 596-602
8. Buchanan RW, Vladar K, Barta PE, Pearlson GD. Structural evaluation of the prefrontal cortex in schizophrenia. American Journal of Psychiatry. 1998; 155: 1049-55
9. Chaturvedi S, Sinha VD. Recurrence of hallucinations in consecutive episodes of schizophrenia and affective disorder. Schizophrenia Research 1990; 3: 103-106
10. Dierks T, Linden DEJ, Jandl M, Formisano E, Goebel R, Lanfermann H, Singer W. Activation of Heschl's gyrus during auditory hallucinations. Neuron 1999; 22: 615-621
11. Eastwood SL, Harrison PJ. Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography. Neuroscience 1999; 69: 339-43
12. Edelman GM. Neural Darwinism: The Theory of Neural Group Selection. NY: Basic Books, 1987
13. Elman JL. Finding structure in time. Cognitive Science 1990; 14: 179-211
14. Feinberg I. Schizophrenia caused by a fault in programmed synaptic elimination during adolescence? Journal of Psychiatric Research 1982/1983; 17: 319-334
15. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clinical Neuroscience 1995; 3: 89-97
16. Frith CD, Done DJ. Experiences of alien control in schizophrenia reflect a disorder in the central monitoring of action. Psychological Medicine 1989; 19: 359-63
17. Garey LJ, Ong WY, Patel TS, Kanani M, Davis A, Mortimer AM, Barnes TR, Hirsch SR. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. Journal of Neurology, Neurosurgery and Psychiatry 1998; 65: 446-53
18. Garrett M, Silva R. Auditory hallucinations, source monitoring and the belief that "voices" are real. Schizophrenia Bulletin 2003; 29: 445-457
19. Glantz LA, Lewis DA. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity. Archives of General Psychiatry 1997; 54: 943-52
20. Glantz LA, Lewis DA. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Archives of General Psychiatry 2000; 57: 65-73
21. Gold JM, Carpenter C, Randolph C, Goldberg TE, Weinberger DR. Auditory working memory and Wisconsin Card Sorting Test Performance in schizophrenia. Archives of General Psychiatry 1997; 54: 159-165
22. Goldman-Rakic PS, Friedman HR. The circuitry of working memory revealed by anatomy and metabolic imaging, in Frontal Lobe Function and Injury. Edited by Leven H, Eisenberg HM. New York: Oxford University Press, 1991
23. Gorelova N, Seamans JK, Yang CR. Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex. Journal of Neurophysiology 2002; 88: 3150-66
24. Gur RE, Cowell PE, Latshaw A, Turetsky BI, Grossman RI, Arnold SE, Bilker WB, Gur RC. Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia. Archives of General Psychiatry 2000; 57: 761-8
25. Gur RE, Turetsky BI, Cowell PE, Finkelman C, Maany V, Grossman RI, Arnold SE, Bilker WB, Gur RC. Temporolimbic volume reductions in schizophrenia. Archives of General Psychiatry. 2000; 57: 769-75
26. Heckers S, Rauch SL, Goff D, Savage CR, Schacter DL, Fischman AJ, Alpert NM. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nature Neuroscience. 1998; 1: 318-23
27. Hoffman RE, Boutros NN, Hu S, Berman RM, Krystal JH, Charney DS. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet 2000; 355: 1073-5
28. Hoffman RE, Cavus I. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. American Journal of Psychiatry 2002; 159: 1093-1102
29. Hoffman RE, Dobscha SK. Cortical pruning and the development of schizophrenia: a computer model. Schizophr Bull 1989; 15: 477-490
30. Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, Krystal JH. transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Archives of General Psychiatry 2003; 60: 49-56
31. Hoffman RE, Hampson, Wu K, Anderson A, Gore J, Buchanan RJ, Varanko M, Constable T, Hawkins K, Sahay N, Krystal JH. Mapping the pathophysiology of auditory hallucinations by combining functional magnetic resonance imaging and trancranial magnetic stimulation. Under review,
32. Hoffman RE, McGlashan TH. Synaptic elimination, neurodevelopment and the mechanism of hallucinated 'voices' in schizophrenia. American Journal of Psychiatry 1997; 154: 1683-1689
33. Hoffman RE, McGlashan TH. Neural network models of schizophrenia. Neuroscientist 2001; 7: 441-454
34. Hoffman RE, Rapaport J, Ameli R, McGlashan TH, Harcherik D, Servan-Schreiber D. A neural network model of hallucinated 'voices' and associated speech perception impairments in schizophrenic patients. Journal of Cognitive Neuroscience 1995; 7: 479-496
35. Hoffman RE, Rapaport J, Mazure C, Quinlan D. Schizophrenic patients reporting hallucinated "voices" demonstrate selective speech perception alterations. American Journal of Psychiatry 1999; 56: 393-399
36. Honer WG, Falkai P, Chen C, Arango V, Mann JJ, Dwork AJ. Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness. Neuroscience 1999; 9: 1247-55
37. Hubl D, Koenig T, Strik W, Federspiel A, Kreis R, Boesch C, Maier SE, Schroth G, Lovblad K, Dierks T. Pathways that make voices: white matter changes in auditory hallucinations. Archives of General Psychiatry 2004; 61: 658-68
38. Huttenlocher PR. Synaptic density in the human frontal cortex-developmental changes and effects of aging. Brain Research 1979; 163: 195-205
39. Huttenlocher PR, Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. Journal of Comparative Neurology 1997; 387: 167-178
40. Jonsson EG, Flyckt L, Burgert E, Crocq MA, Forslund K, Mattila-Evenden M, Rylander G, Asberg M, Nimgaonkar VL, Edman G, Bjerkenstedt L, Wiesel FA, Sedvall GC. Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis. Psychiatric Genetics 2003; 13: 1-12
41. Kalikow DN, Stevens KN. Development of a test of speech intelligibility in noise using sentence materials with controlled word predictability. Journal of the Acoustic Society of America 1977; 5: 1337-1351
42. Kapur S, Seeman P. Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics? A new hypothesis. American Journal of Psychiatry 2001; 158: 360-9
43. Karson CN, Mrak RE, Schluterman KO, Sturner WQ, Sheng JG, Griffin WS. Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for 'hypofrontality'. Molecular Psychiatry 1999; 4: 39-45
44. Laakso A, Vilkman H, Alakare B, Haaparanta M, Bergman J, Solin O, Peurasaari J, Rakkolainen V, Syvalahti E, Hietala J. Striatal dopamine transporter binding in neuroleptic-naive patients with schizophrenia studied with positron emission tomography. American Journal of Psychiatry 2000; 157: 269-71.
45. Laruelle M. The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies. Brain Research - Brain Research Reviews 2000; 31: 371-84
46. Le Cun Y, Denker JS, Solla SA. Optimal brain damage, in Advances in Neural Information Processing Systems.; vol 2 Edited by Touretsky DS. San Francisco: Morgan Kauffmann, 1990: pp 598-605
47. Lim KO, Hedehus M, Moseley M, de Crespigny A, Sullivan EV, Pfefferbaum A. Compromised white matter tract integrity in schizophrenia inferred diffusion tensor imaging. Archives of General Psychiatry 1999; 56: 367-74
48. Margolis RL, Chuang D-M, Post RM. Programmed cell death: Implications for neuropsychiatric disorders. Biological Psychiatry 1995; 35: 946-956
49. McGlashan TH, Hoffman RE. Schizophrenia as a disorder of developmentally reduced synaptic connectivity. Archives of General Psychiatry 2000; 57: 637-648
50. McGuire PK, Shah CMS, Murray RM. Increased blood flow in Broca's area during auditory hallucinations in schizophrenia. Lancet 1993; 342: 703-06
51. Miikkulainen R. Subsymbolic natural language processing: An integrated model of scripts, lexicon and memory. Cambridge Mass: MIT Press, 1993
52. Munoz-Cueto A, Garcia-Segura M, Ruiz-Marcos A. Developmental sex differences and effect of ovariectomy on the number of cortical pyramidal cell dendritic spines. Brain Research 1990; 515: 64-68
53. Naftolin F, Garcia-Segura LM, Keefe D, Leranth C, Maclusky NJ, Brawer JR. Estrogen effects on the synaptology and neural membranes of the rat hypothalamic arcuate nucleus. Biological Reprodruction 1990; 42: 21-28
54. Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Archives of General Psychaitry 1995; 52: 998-1007
55. Pakkenberg B. Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors. Biological Psychiatry 1993; 34: 768-772
56. Park S, Holzman PS. Schizophrenics show spatial working memory deficits. Archives of General Psychiatry 1992; 49: 975-982
57. Sartorious N, Shapiro R, Jablonsky A. The international pilot study of schizophrenia. Schizophrenia Bulletin 1974; 1: 21-35
58. Scheich H, Wallhausseer-Franke E, Braun K. Does synaptic selection explain auditory imprinting. In Memory: Organization and locus of change Edited by LR Squire, NM Weinberger, G Lynch, JL McGaugh. New York: Oxford University Press, 1991
59. Selemon LD, Rajkowski G, Goldman-Rakic PS. Abnormally high neuronal density in schizophrenic cortex: A morphometric analysis of prefrontal area 9 and occipatal cortex area 17. Archives of General Psychiatry 1995; 52: 805-818
60. Selemon LD, Rajkowski G, Goldman-Rakic PS. Abnormally high neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of 3-dimensional stereologic counting method. Journal of Comparative Neurology 1998; 392: 402-412
61. Shergill SS, Brammer MJ, Williams SCR, Murray RM, McGuire PK. Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Arch Gen Psychiatry 2000; 57: 1033-1038
62. Tamminga CA, Vogel M, Gao X, Lahti AC, Holcomb HH. The limbic cortex in schizophrenia: focus on the anterior cingulate. Brain Research Brain Research Reviews 2000; 31: 364-70
63. Thierry G, Boulanouar K, Kherif F, Ranjeva JP, Demonet JF. Temporal sorting of neural components underlying phonological processing. Neuroreport 1999; 10: 2599-603
64. Tiihonen J, Hari R, Naukkarinen H, Rimon R, Jousmaki V, Kajoli M. Modified activity of the human auditory cortex during auditory hallucinations. American Journal of Psychiatry 1992; 149: 255-257
65. Velakoulis D, Pantelis C, McGorry PD, Dudgeon P, Brewer W, Cook M, Desmond P, Bridle N, Tierney P, Murrie V, Singh B, Copolov D. Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Archives of General Psychiatry 1999; 56: 133-41
66. Wang Y, Goldman-Rakic S. D2 receptor regulation of synaptic burst firing in prefrontal cortical pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America 2004; 101: 5093-8
67. Warren RM, Warren RP. Auditory illusions and confusions. Scientific American 1970; 223: 30-36
68. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 1987; 44: 660-669
69. Weinberger DR, Berman KF, Suddath R, Torrey EF. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. American Journal of Psychiatry 1992; 149: 890-7
70. Woolley CS, Wenzel HJ, Schwartzkroin PA. Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rat. Journal of Comparative Neurology 1996; 373: 108-117
71. Young CE, Arima K, Xie J, Hu L, Beach TG, Falkai P, Honer WG. SNAP-25 deficit and hippocampal connectivity in schizophrenia. Cerebral Cortex 1998; 8: 261-8