-
1
-
-
8444232772
-
New horizons in the development of antiepileptic drugs: The search for new targets
-
Loescher W, Schmidt D. New horizons in the development of antiepileptic drugs: the search for new targets. Epilepsy Res 2004;60:77-159.
-
(2004)
Epilepsy Res
, vol.60
, pp. 77-159
-
-
Loescher, W.1
Schmidt, D.2
-
2
-
-
0037669865
-
Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats
-
Remy S, Urban BW, Elger CE, et al. Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats. Eur J Neurosci 2003;17:2648-58.
-
(2003)
Eur J Neurosci
, vol.17
, pp. 2648-2658
-
-
Remy, S.1
Urban, B.W.2
Elger, C.E.3
-
3
-
-
0034598762
-
Early identification of refractory epilepsy
-
Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314-9.
-
(2000)
N Engl J Med
, vol.342
, pp. 314-319
-
-
Kwan, P.1
Brodie, M.J.2
-
4
-
-
0345382778
-
A novel mechanism underlying drug resistance in chronic epilepsy
-
Remy S, Gabriel S, Urban BW, et al. A novel mechanism underlying drug resistance in chronic epilepsy. Ann Neurol 2003;53:469-79.
-
(2003)
Ann Neurol
, vol.53
, pp. 469-479
-
-
Remy, S.1
Gabriel, S.2
Urban, B.W.3
-
5
-
-
1842850796
-
Clinical correlations of mutations in the SCN1A gene: From febrile seizures to severe myoclonic epilepsy in infancy
-
Ceulemans BP, Claes LR, Lagae LG. Clinical correlations of mutations in the SCN1A gene: from febrile seizures to severe myoclonic epilepsy in infancy. Pediatr Neurol 2004;30:236-43.
-
(2004)
Pediatr Neurol
, vol.30
, pp. 236-243
-
-
Ceulemans, B.P.1
Claes, L.R.2
Lagae, L.G.3
-
7
-
-
12144286141
-
A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline
-
Kamiya K, Kaneda M, Sugawara T, et al. A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. J Neurosci 2004;24:2690-8.
-
(2004)
J Neurosci
, vol.24
, pp. 2690-2698
-
-
Kamiya, K.1
Kaneda, M.2
Sugawara, T.3
-
9
-
-
0037312921
-
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
-
Lohmueller KE, Pearce CL, Pike M, et al. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003;33:177-82.
-
(2003)
Nat Genet
, vol.33
, pp. 177-182
-
-
Lohmueller, K.E.1
Pearce, C.L.2
Pike, M.3
-
10
-
-
0036517472
-
A comprehensive review of genetic association studies
-
Hirschhorn JN, Lohmueller K, Byrne E, et al. A comprehensive review of genetic association studies. Genet Med 2002;4:45-61.
-
(2002)
Genet Med
, vol.4
, pp. 45-61
-
-
Hirschhorn, J.N.1
Lohmueller, K.2
Byrne, E.3
-
11
-
-
0037426052
-
Problems of reporting genetic associations with complex outcomes
-
Colhoun HM, McKeigue PM, Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 2003;361:865-72.
-
(2003)
Lancet
, vol.361
, pp. 865-872
-
-
Colhoun, H.M.1
McKeigue, P.M.2
Davey Smith, G.3
-
12
-
-
7944233055
-
Genetic association studies in epilepsy: "The truth is out there."
-
Tan NC, Mulley JC, Berkovic SF. Genetic association studies in epilepsy: "the truth is out there." Epilepsia 2004;45:1429-42.
-
(2004)
Epilepsia
, vol.45
, pp. 1429-1442
-
-
Tan, N.C.1
Mulley, J.C.2
Berkovic, S.F.3
-
13
-
-
0033625146
-
Interleukin (IL)1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy
-
Kanemoto K, Kawasaki J, Miyamoto T, et al. Interleukin (IL)1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy. Ann Neurol 2000;47:571-4.
-
(2000)
Ann Neurol
, vol.47
, pp. 571-574
-
-
Kanemoto, K.1
Kawasaki, J.2
Miyamoto, T.3
-
14
-
-
0034548654
-
Interleukin-1beta gene polymorphism and susceptibility to temporal lobe epilepsy with hippocampal sclerosis
-
Heils A, Haug K, Kunz WS, et al. Interleukin-1beta gene polymorphism and susceptibility to temporal lobe epilepsy with hippocampal sclerosis. Ann Neurol 2000;48:948-50.
-
(2000)
Ann Neurol
, vol.48
, pp. 948-950
-
-
Heils, A.1
Haug, K.2
Kunz, W.S.3
-
15
-
-
0142104320
-
Association analysis of a polymorphism of interleukin 1 beta (IL-1 beta) gene with temporal lobe epilepsy in a Chinese population
-
Jin L, Jia Y, Zhang B, et al. Association analysis of a polymorphism of interleukin 1 beta (IL-1 beta) gene with temporal lobe epilepsy in a Chinese population. Epilepsia 2003;44:1306-9.
-
(2003)
Epilepsia
, vol.44
, pp. 1306-1309
-
-
Jin, L.1
Jia, Y.2
Zhang, B.3
-
16
-
-
0034949135
-
Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy
-
Buono RJ, Ferraro TN, O'Connor MJ, et al. Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy. Epilepsia 2001;42:782-4.
-
(2001)
Epilepsia
, vol.42
, pp. 782-784
-
-
Buono, R.J.1
Ferraro, T.N.2
O'Connor, M.J.3
-
17
-
-
0034899318
-
Polymorphism of the interleukin-1 gene complex in localization-related epilepsy
-
Peltola J, Keranen T, Rainesalo S, et al. Polymorphism of the interleukin-1 gene complex in localization-related epilepsy. Ann Neurol 2001;50:275-6.
-
(2001)
Ann Neurol
, vol.50
, pp. 275-276
-
-
Peltola, J.1
Keranen, T.2
Rainesalo, S.3
-
18
-
-
23444437212
-
Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: Where to from here?
-
Cavalleri G, Lynch JM, Depondt C, et al. Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: where to from here? Brain 2005;128:1832-40.
-
(2005)
Brain
, vol.128
, pp. 1832-1840
-
-
Cavalleri, G.1
Lynch, J.M.2
Depondt, C.3
-
19
-
-
0036156977
-
A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy
-
Stogmann E, Zimprich A, Baumgartner C, et al. A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy. Ann Neurol 2002;51:260-3.
-
(2002)
Ann Neurol
, vol.51
, pp. 260-263
-
-
Stogmann, E.1
Zimprich, A.2
Baumgartner, C.3
-
20
-
-
0037310785
-
Prodynorphin gene promoter polymorphism and temporal lobe epilepsy
-
Tilgen N, Rebstock J, Horvath S, et al. Prodynorphin gene promoter polymorphism and temporal lobe epilepsy. Ann Neurol 2003;53:280-1.
-
(2003)
Ann Neurol
, vol.53
, pp. 280-281
-
-
Tilgen, N.1
Rebstock, J.2
Horvath, S.3
-
21
-
-
0041914558
-
Prodynorphin gene promoter polymorphism and temporal lobe epilepsy
-
Gambardella A, Manna I, Labate A, et al. Prodynorphin gene promoter polymorphism and temporal lobe epilepsy. Epilepsia 2003;44:1255-6.
-
(2003)
Epilepsia
, vol.44
, pp. 1255-1256
-
-
Gambardella, A.1
Manna, I.2
Labate, A.3
-
22
-
-
0037465373
-
GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy
-
Gambardella A, Manna I, Labate A, et al. GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy. Neurology 2003;60:560-3.
-
(2003)
Neurology
, vol.60
, pp. 560-563
-
-
Gambardella, A.1
Manna, I.2
Labate, A.3
-
23
-
-
0032806450
-
Increased sensitivity to seizures in mice lacking cellular prion protein
-
Walz R, Amaral OB, Rockenbach IC, et al. Increased sensitivity to seizures in mice lacking cellular prion protein. Epilepsia 1999;40:1679-82.
-
(1999)
Epilepsia
, vol.40
, pp. 1679-1682
-
-
Walz, R.1
Amaral, O.B.2
Rockenbach, I.C.3
-
24
-
-
10744222194
-
Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant
-
Walz R, Castro RM, Velasco TR, et al. Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant. Neurology 2003;61:1204-10.
-
(2003)
Neurology
, vol.61
, pp. 1204-1210
-
-
Walz, R.1
Castro, R.M.2
Velasco, T.R.3
-
25
-
-
0242684410
-
Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics
-
Mead S, Stumpf MP, Whitfield J, et al. Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics. Science 2003;300:640-3.
-
(2003)
Science
, vol.300
, pp. 640-643
-
-
Mead, S.1
Stumpf, M.P.2
Whitfield, J.3
-
26
-
-
0033624166
-
APOE epsilon4 genotype is associated with an earlier onset of chronic temporal lobe epilepsy
-
Briellmann RS, Torn-Broers Y, Busuttil BE, et al. APOE epsilon4 genotype is associated with an earlier onset of chronic temporal lobe epilepsy. Neurology 2000;55:435-7.
-
(2000)
Neurology
, vol.55
, pp. 435-437
-
-
Briellmann, R.S.1
Torn-Broers, Y.2
Busuttil, B.E.3
-
27
-
-
0030612502
-
The apolipoprotein E epsilon 4 allele is not associated with early onset temporal lobe epilepsy
-
Blumcke I, Brockhaus A, Scheiwe C, et al. The apolipoprotein E epsilon 4 allele is not associated with early onset temporal lobe epilepsy. Neuroreport 1997;8:1235-7.
-
(1997)
Neuroreport
, vol.8
, pp. 1235-1237
-
-
Blumcke, I.1
Brockhaus, A.2
Scheiwe, C.3
-
28
-
-
0032786908
-
Apolipoprotein E polymorphisms and the risk of nonlesional temporal lobe epilepsy
-
Gambardella A, Aguglia U, Cittadella R, et al. Apolipoprotein E polymorphisms and the risk of nonlesional temporal lobe epilepsy. Epilepsia 1999;40:1804-7.
-
(1999)
Epilepsia
, vol.40
, pp. 1804-1807
-
-
Gambardella, A.1
Aguglia, U.2
Cittadella, R.3
-
29
-
-
0037431040
-
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
-
Siddiqui A, Kerb R, Weale ME, et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 2003;348:1442-8.
-
(2003)
N Engl J Med
, vol.348
, pp. 1442-1448
-
-
Siddiqui, A.1
Kerb, R.2
Weale, M.E.3
-
30
-
-
4644230833
-
Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy
-
Tan NC, Heron SE, Scheffer IE, et al. Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy. Neurology 2004;63:1090-2.
-
(2004)
Neurology
, vol.63
, pp. 1090-1092
-
-
Tan, N.C.1
Heron, S.E.2
Scheffer, I.E.3
-
31
-
-
4644305242
-
Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy
-
Zimprich F, Sunder-Plassmann R, Stogmann E, et al. Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy. Neurology 2004;63:1087-9.
-
(2004)
Neurology
, vol.63
, pp. 1087-1089
-
-
Zimprich, F.1
Sunder-Plassmann, R.2
Stogmann, E.3
-
32
-
-
0037399407
-
Mechanisms of antiepileptic drug resistance
-
Sisodiya SM. Mechanisms of antiepileptic drug resistance. Curr Opin Neurol 2003;16:197-201.
-
(2003)
Curr Opin Neurol
, vol.16
, pp. 197-201
-
-
Sisodiya, S.M.1
-
33
-
-
0036128985
-
Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
-
Loscher W, Potschka H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther 2002;301:7-14.
-
(2002)
J Pharmacol Exp Ther
, vol.301
, pp. 7-14
-
-
Loscher, W.1
Potschka, H.2
-
34
-
-
3543149022
-
Identifying candidate causal variants responsible for altered activity of the ABCB1 multi-drug resistance gene product
-
Soranzo N, Cavalleri G, Wood NW, et al. Identifying candidate causal variants responsible for altered activity of the ABCB1 multi-drug resistance gene product. Genome Res 2004;14:1333-44.
-
(2004)
Genome Res
, vol.14
, pp. 1333-1344
-
-
Soranzo, N.1
Cavalleri, G.2
Wood, N.W.3
-
35
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;20;350:2129-39.
-
(2004)
N Engl J Med
, vol.20
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
36
-
-
21644446343
-
Mutations in the EGFR: The Importance of Genotyping
-
Price DK, Figg WD. Mutations in the EGFR: the Importance of Genotyping. Cancer Biol Ther 2004;3:434-5.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 434-435
-
-
Price, D.K.1
Figg, W.D.2
-
38
-
-
4344684441
-
Pharmacogenetics and drug development: The path to safer and more effective drugs
-
Roses AD. Pharmacogenetics and drug development: the path to safer and more effective drugs. Nat Rev Genet 2004;5:645-56.
-
(2004)
Nat Rev Genet
, vol.5
, pp. 645-656
-
-
Roses, A.D.1
-
39
-
-
4143134235
-
The future of association studies: Gene-based analysis and replication
-
Neale BM, Sham PC. The future of association studies: gene-based analysis and replication. Am J Hum Genet 2004;75:353-62.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 353-362
-
-
Neale, B.M.1
Sham, P.C.2
|