-
1
-
-
0035856942
-
Mitochondrial function in normal and diabetic beta-cells
-
Maechler P, Wollheim CB (2001) Mitochondrial function in normal and diabetic beta-cells. Nature 414:807-812
-
(2001)
Nature
, vol.414
, pp. 807-812
-
-
Maechler, P.1
Wollheim, C.B.2
-
2
-
-
0036865991
-
Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells
-
Maechler P (2002) Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells. Cell Mol Life Sci 59:1803-1818
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 1803-1818
-
-
Maechler, P.1
-
3
-
-
0036323649
-
Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation
-
Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ (2002) Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes 51:2496-2504
-
(2002)
Diabetes
, vol.51
, pp. 2496-2504
-
-
Alarcon, C.1
Wicksteed, B.2
Prentki, M.3
Corkey, B.E.4
Rhodes, C.J.5
-
4
-
-
0021187646
-
+ channels in pancreatic B-cells
-
+ channels in pancreatic B-cells. Nature 311:271-273
-
(1984)
Nature
, vol.311
, pp. 271-273
-
-
Cook, D.L.1
Hales, C.N.2
-
5
-
-
0842310006
-
Regulation of ATP/ADP in pancreatic islets
-
Sweet IR, Cook DL, DeJulio E et al (2004) Regulation of ATP/ADP in pancreatic islets. Diabetes 53:401-409
-
(2004)
Diabetes
, vol.53
, pp. 401-409
-
-
Sweet, I.R.1
Cook, D.L.2
DeJulio, E.3
-
6
-
-
0037413433
-
The export of metabolites from mitochondria and anaplerosis in insulin secretion
-
MacDonald MJ (2003) The export of metabolites from mitochondria and anaplerosis in insulin secretion. Biochim Biophys Acta 1619:77-88
-
(2003)
Biochim Biophys Acta
, vol.1619
, pp. 77-88
-
-
MacDonald, M.J.1
-
7
-
-
0036300460
-
Critical role for cataplerosis via citrate in glucose-regulated insulin release
-
Flamez D, Berger V, Kruhoffer M, Orntoft T, Pipeleers D, Schuit FC (2002) Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes 51:2018-2024
-
(2002)
Diabetes
, vol.51
, pp. 2018-2024
-
-
Flamez, D.1
Berger, V.2
Kruhoffer, M.3
Orntoft, T.4
Pipeleers, D.5
Schuit, F.C.6
-
8
-
-
0032522368
-
A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties
-
Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ (1998) A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J 331:553-561
-
(1998)
Biochem J
, vol.331
, pp. 553-561
-
-
Skelly, R.H.1
Bollheimer, L.C.2
Wicksteed, B.L.3
Corkey, B.E.4
Rhodes, C.J.5
-
9
-
-
0033540037
-
Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
-
Maechler P, Wollheim CB (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402:685-689
-
(1999)
Nature
, vol.402
, pp. 685-689
-
-
Maechler, P.1
Wollheim, C.B.2
-
10
-
-
0034602141
-
Glutamate is not a messenger in insulin secretion
-
MacDonald MJ, Fahien LA (2000) Glutamate is not a messenger in insulin secretion. J Biol Chem 275:34025-34027
-
(2000)
J Biol Chem
, vol.275
, pp. 34025-34027
-
-
MacDonald, M.J.1
Fahien, L.A.2
-
11
-
-
0346434160
-
Citrate oscillates in liver and pancreatic beta cell mitochondria and in INS-1 insulinoma cells
-
MacDonald MJ, Fahien LA, Buss JD, Hasan NM, Fallon MJ, Kendrick MA (2003) Citrate oscillates in liver and pancreatic beta cell mitochondria and in INS-1 insulinoma cells. J Biol Chem 278:51894-51900
-
(2003)
J Biol Chem
, vol.278
, pp. 51894-51900
-
-
MacDonald, M.J.1
Fahien, L.A.2
Buss, J.D.3
Hasan, N.M.4
Fallon, M.J.5
Kendrick, M.A.6
-
12
-
-
0034072556
-
Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: Possible implication of a pyruvate/citrate shuttle in insulin secretion
-
Farfari S, Schulz V, Corkey B, Prentki M (2000) Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 49:718-726
-
(2000)
Diabetes
, vol.49
, pp. 718-726
-
-
Farfari, S.1
Schulz, V.2
Corkey, B.3
Prentki, M.4
-
13
-
-
0036894293
-
Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: Insights gained from a multidisciplinary approach
-
Newgard CB, Lu D, Jensen MV et al (2002) Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach. Diabetes 51 [Suppl 3]:S389-S393
-
(2002)
Diabetes
, vol.51
, Issue.3 SUPPL.
-
-
Newgard, C.B.1
Lu, D.2
Jensen, M.V.3
-
14
-
-
0035794185
-
Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells
-
Mulder H, Lu D, Finley J et al (2001) Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells. J Biol Chem 276:6479-6484
-
(2001)
J Biol Chem
, vol.276
, pp. 6479-6484
-
-
Mulder, H.1
Lu, D.2
Finley, J.3
-
15
-
-
0037031896
-
The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related
-
Bertrand G, Ishiyama N, Nenquin M, Ravier MA, Henquin JC (2002) The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related. J Biol Chem 277:32883-32891
-
(2002)
J Biol Chem
, vol.277
, pp. 32883-32891
-
-
Bertrand, G.1
Ishiyama, N.2
Nenquin, M.3
Ravier, M.A.4
Henquin, J.C.5
-
16
-
-
12144291143
-
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
-
Roduit R, Nolan C, Alarcon C et al (2004) A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes 53:1007-1019
-
(2004)
Diabetes
, vol.53
, pp. 1007-1019
-
-
Roduit, R.1
Nolan, C.2
Alarcon, C.3
-
17
-
-
0037382747
-
Insulin does not mediate glucose stimulation of proinsulin biosynthesis
-
Leibowitz G, Oprescu AI, Uckaya G, Gross DJ, Cerasi E, Kaiser N (2003) Insulin does not mediate glucose stimulation of proinsulin biosynthesis. Diabetes 52:998-1003
-
(2003)
Diabetes
, vol.52
, pp. 998-1003
-
-
Leibowitz, G.1
Oprescu, A.I.2
Uckaya, G.3
Gross, D.J.4
Cerasi, E.5
Kaiser, N.6
-
18
-
-
0142149134
-
Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin
-
Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ (2003) Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 278:42080-42090
-
(2003)
J Biol Chem
, vol.278
, pp. 42080-42090
-
-
Wicksteed, B.1
Alarcon, C.2
Briaud, I.3
Lingohr, M.K.4
Rhodes, C.J.5
-
19
-
-
0036721124
-
Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure
-
Leibowitz G, Uckaya G, Oprescu AI, Cerasi E, Gross DJ, Kaiser N (2002) Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure. Endocrinology 143:3214-3220
-
(2002)
Endocrinology
, vol.143
, pp. 3214-3220
-
-
Leibowitz, G.1
Uckaya, G.2
Oprescu, A.I.3
Cerasi, E.4
Gross, D.J.5
Kaiser, N.6
-
20
-
-
0028085339
-
Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus
-
Gadot M, Leibowitz G, Shafrir E, Cerasi E, Gross D, Kaiser N (1994) Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus. Endocrinology 135:610-616
-
(1994)
Endocrinology
, vol.135
, pp. 610-616
-
-
Gadot, M.1
Leibowitz, G.2
Shafrir, E.3
Cerasi, E.4
Gross, D.5
Kaiser, N.6
-
21
-
-
77955093164
-
Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid
-
Sener A, Malaisse-Lagae F, Malaisse WJ (1981) Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc Natl Acad Sci U S A 78:5460-5464
-
(1981)
Proc Natl Acad Sci U S A
, vol.78
, pp. 5460-5464
-
-
Sener, A.1
Malaisse-Lagae, F.2
Malaisse, W.J.3
-
22
-
-
0027418977
-
The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets
-
Alarcon C, Lincoln B, Rhodes CJ (1993) The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem 268:4276-4280
-
(1993)
J Biol Chem
, vol.268
, pp. 4276-4280
-
-
Alarcon, C.1
Lincoln, B.2
Rhodes, C.J.3
-
23
-
-
0042531617
-
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
-
Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V (2003) Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem 278:30015-30021
-
(2003)
J Biol Chem
, vol.278
, pp. 30015-30021
-
-
Kelpe, C.L.1
Moore, P.C.2
Parazzoli, S.D.3
Wicksteed, B.4
Rhodes, C.J.5
Poitout, V.6
-
24
-
-
3242718780
-
Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 week in high glucose
-
Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC (2004) Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 week in high glucose. Am J Physiol Endocrinol Metab 287:E207-E217
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Khaldi, M.Z.1
Guiot, Y.2
Gilon, P.3
Henquin, J.C.4
Jonas, J.C.5
-
25
-
-
0345120940
-
Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
-
Scaduto RC Jr, Grofyohann LW (1999) Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys J 76:469-477
-
(1999)
Biophys J
, vol.76
, pp. 469-477
-
-
Scaduto Jr., R.C.1
Grofyohann, L.W.2
-
26
-
-
0037023692
-
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: A survey of four fuel secretagogues
-
Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB (2002) Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. J Biol Chem 277:11746-11755
-
(2002)
J Biol Chem
, vol.277
, pp. 11746-11755
-
-
Antinozzi, P.A.1
Ishihara, H.2
Newgard, C.B.3
Wollheim, C.B.4
-
27
-
-
0023645786
-
Myeloperoxidase-mediated damage to the succinate oxidase system of Escherichia coli. Evidence for selective inactivation of the dehydrogenase component
-
Rosen H, Rakita RM, Waltersdorph AM, Klebanoff SJ (1987) Myeloperoxidase-mediated damage to the succinate oxidase system of Escherichia coli. Evidence for selective inactivation of the dehydrogenase component. J Biol Chem 262:15004-15010
-
(1987)
J Biol Chem
, vol.262
, pp. 15004-15010
-
-
Rosen, H.1
Rakita, R.M.2
Waltersdorph, A.M.3
Klebanoff, S.J.4
-
29
-
-
0036326235
-
Differences between mouse and rat pancreatic islets: Succinate responsiveness, malic enzyme, and anaplerosis
-
MacDonald MJ (2002) Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis. Am J Physiol Endocrinol Metab 283:E302-E310
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
MacDonald, M.J.1
-
30
-
-
0037474212
-
Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets
-
Li C, Najafi H, Daikhin Y et al (2003) Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. J Biol Chem 278:2853-2858
-
(2003)
J Biol Chem
, vol.278
, pp. 2853-2858
-
-
Li, C.1
Najafi, H.2
Daikhin, Y.3
-
31
-
-
0036787462
-
Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells
-
McDaniel ML, Marshall CA, Pappan KL, Kwon G (2002) Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes 51:2877-2885
-
(2002)
Diabetes
, vol.51
, pp. 2877-2885
-
-
McDaniel, M.L.1
Marshall, C.A.2
Pappan, K.L.3
Kwon, G.4
-
32
-
-
0027154077
-
Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters
-
Melloul D, Ben-Neriah Y, Cerasi E (1993) Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci U S A 90:3865-3869
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 3865-3869
-
-
Melloul, D.1
Ben-Neriah, Y.2
Cerasi, E.3
-
33
-
-
0030447883
-
Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
-
Marshak S, Totary H, Cerasi E, Melloul D (1996) Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci U S A 93:15057-15062
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 15057-15062
-
-
Marshak, S.1
Totary, H.2
Cerasi, E.3
Melloul, D.4
-
34
-
-
0035431017
-
IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal with type 2 diabetes
-
Leibowitz G, Ferber S, Apelqvist A et al (2001) IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal with type 2 diabetes. Diabetes 50:1799-1806
-
(2001)
Diabetes
, vol.50
, pp. 1799-1806
-
-
Leibowitz, G.1
Ferber, S.2
Apelqvist, A.3
|