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Volumn 48, Issue 8, 2005, Pages 1549-1559

Mitochondrial regulation of insulin production in rat pancreatic islets

Author keywords

Insulin secretion; Islets; Mitochondria; Preproinsulin gene transcription; Proinsulin biosynthesis; Rat; Succinate; Succinate dehydrogenase

Indexed keywords

ADENOVIRUS VECTOR; FUMARIC ACID; GLUCOSE; LUCIFERASE; MESSENGER RNA; PROINSULIN; SUCCINATE DEHYDROGENASE; SUCCINIC ACID;

EID: 23844431989     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1811-6     Document Type: Article
Times cited : (21)

References (34)
  • 1
    • 0035856942 scopus 로고    scopus 로고
    • Mitochondrial function in normal and diabetic beta-cells
    • Maechler P, Wollheim CB (2001) Mitochondrial function in normal and diabetic beta-cells. Nature 414:807-812
    • (2001) Nature , vol.414 , pp. 807-812
    • Maechler, P.1    Wollheim, C.B.2
  • 2
    • 0036865991 scopus 로고    scopus 로고
    • Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells
    • Maechler P (2002) Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells. Cell Mol Life Sci 59:1803-1818
    • (2002) Cell Mol Life Sci , vol.59 , pp. 1803-1818
    • Maechler, P.1
  • 3
    • 0036323649 scopus 로고    scopus 로고
    • Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation
    • Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ (2002) Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes 51:2496-2504
    • (2002) Diabetes , vol.51 , pp. 2496-2504
    • Alarcon, C.1    Wicksteed, B.2    Prentki, M.3    Corkey, B.E.4    Rhodes, C.J.5
  • 4
    • 0021187646 scopus 로고
    • + channels in pancreatic B-cells
    • + channels in pancreatic B-cells. Nature 311:271-273
    • (1984) Nature , vol.311 , pp. 271-273
    • Cook, D.L.1    Hales, C.N.2
  • 5
    • 0842310006 scopus 로고    scopus 로고
    • Regulation of ATP/ADP in pancreatic islets
    • Sweet IR, Cook DL, DeJulio E et al (2004) Regulation of ATP/ADP in pancreatic islets. Diabetes 53:401-409
    • (2004) Diabetes , vol.53 , pp. 401-409
    • Sweet, I.R.1    Cook, D.L.2    DeJulio, E.3
  • 6
    • 0037413433 scopus 로고    scopus 로고
    • The export of metabolites from mitochondria and anaplerosis in insulin secretion
    • MacDonald MJ (2003) The export of metabolites from mitochondria and anaplerosis in insulin secretion. Biochim Biophys Acta 1619:77-88
    • (2003) Biochim Biophys Acta , vol.1619 , pp. 77-88
    • MacDonald, M.J.1
  • 8
    • 0032522368 scopus 로고    scopus 로고
    • A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties
    • Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ (1998) A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J 331:553-561
    • (1998) Biochem J , vol.331 , pp. 553-561
    • Skelly, R.H.1    Bollheimer, L.C.2    Wicksteed, B.L.3    Corkey, B.E.4    Rhodes, C.J.5
  • 9
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P, Wollheim CB (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402:685-689
    • (1999) Nature , vol.402 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 10
    • 0034602141 scopus 로고    scopus 로고
    • Glutamate is not a messenger in insulin secretion
    • MacDonald MJ, Fahien LA (2000) Glutamate is not a messenger in insulin secretion. J Biol Chem 275:34025-34027
    • (2000) J Biol Chem , vol.275 , pp. 34025-34027
    • MacDonald, M.J.1    Fahien, L.A.2
  • 11
    • 0346434160 scopus 로고    scopus 로고
    • Citrate oscillates in liver and pancreatic beta cell mitochondria and in INS-1 insulinoma cells
    • MacDonald MJ, Fahien LA, Buss JD, Hasan NM, Fallon MJ, Kendrick MA (2003) Citrate oscillates in liver and pancreatic beta cell mitochondria and in INS-1 insulinoma cells. J Biol Chem 278:51894-51900
    • (2003) J Biol Chem , vol.278 , pp. 51894-51900
    • MacDonald, M.J.1    Fahien, L.A.2    Buss, J.D.3    Hasan, N.M.4    Fallon, M.J.5    Kendrick, M.A.6
  • 12
    • 0034072556 scopus 로고    scopus 로고
    • Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: Possible implication of a pyruvate/citrate shuttle in insulin secretion
    • Farfari S, Schulz V, Corkey B, Prentki M (2000) Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 49:718-726
    • (2000) Diabetes , vol.49 , pp. 718-726
    • Farfari, S.1    Schulz, V.2    Corkey, B.3    Prentki, M.4
  • 13
    • 0036894293 scopus 로고    scopus 로고
    • Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: Insights gained from a multidisciplinary approach
    • Newgard CB, Lu D, Jensen MV et al (2002) Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach. Diabetes 51 [Suppl 3]:S389-S393
    • (2002) Diabetes , vol.51 , Issue.3 SUPPL.
    • Newgard, C.B.1    Lu, D.2    Jensen, M.V.3
  • 14
    • 0035794185 scopus 로고    scopus 로고
    • Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells
    • Mulder H, Lu D, Finley J et al (2001) Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells. J Biol Chem 276:6479-6484
    • (2001) J Biol Chem , vol.276 , pp. 6479-6484
    • Mulder, H.1    Lu, D.2    Finley, J.3
  • 15
    • 0037031896 scopus 로고    scopus 로고
    • The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related
    • Bertrand G, Ishiyama N, Nenquin M, Ravier MA, Henquin JC (2002) The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related. J Biol Chem 277:32883-32891
    • (2002) J Biol Chem , vol.277 , pp. 32883-32891
    • Bertrand, G.1    Ishiyama, N.2    Nenquin, M.3    Ravier, M.A.4    Henquin, J.C.5
  • 16
    • 12144291143 scopus 로고    scopus 로고
    • A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
    • Roduit R, Nolan C, Alarcon C et al (2004) A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes 53:1007-1019
    • (2004) Diabetes , vol.53 , pp. 1007-1019
    • Roduit, R.1    Nolan, C.2    Alarcon, C.3
  • 18
    • 0142149134 scopus 로고    scopus 로고
    • Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin
    • Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ (2003) Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 278:42080-42090
    • (2003) J Biol Chem , vol.278 , pp. 42080-42090
    • Wicksteed, B.1    Alarcon, C.2    Briaud, I.3    Lingohr, M.K.4    Rhodes, C.J.5
  • 19
    • 0036721124 scopus 로고    scopus 로고
    • Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure
    • Leibowitz G, Uckaya G, Oprescu AI, Cerasi E, Gross DJ, Kaiser N (2002) Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure. Endocrinology 143:3214-3220
    • (2002) Endocrinology , vol.143 , pp. 3214-3220
    • Leibowitz, G.1    Uckaya, G.2    Oprescu, A.I.3    Cerasi, E.4    Gross, D.J.5    Kaiser, N.6
  • 21
    • 77955093164 scopus 로고
    • Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid
    • Sener A, Malaisse-Lagae F, Malaisse WJ (1981) Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc Natl Acad Sci U S A 78:5460-5464
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 5460-5464
    • Sener, A.1    Malaisse-Lagae, F.2    Malaisse, W.J.3
  • 22
    • 0027418977 scopus 로고
    • The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets
    • Alarcon C, Lincoln B, Rhodes CJ (1993) The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem 268:4276-4280
    • (1993) J Biol Chem , vol.268 , pp. 4276-4280
    • Alarcon, C.1    Lincoln, B.2    Rhodes, C.J.3
  • 23
    • 0042531617 scopus 로고    scopus 로고
    • Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
    • Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V (2003) Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem 278:30015-30021
    • (2003) J Biol Chem , vol.278 , pp. 30015-30021
    • Kelpe, C.L.1    Moore, P.C.2    Parazzoli, S.D.3    Wicksteed, B.4    Rhodes, C.J.5    Poitout, V.6
  • 24
    • 3242718780 scopus 로고    scopus 로고
    • Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 week in high glucose
    • Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC (2004) Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 week in high glucose. Am J Physiol Endocrinol Metab 287:E207-E217
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Khaldi, M.Z.1    Guiot, Y.2    Gilon, P.3    Henquin, J.C.4    Jonas, J.C.5
  • 25
    • 0345120940 scopus 로고    scopus 로고
    • Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
    • Scaduto RC Jr, Grofyohann LW (1999) Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys J 76:469-477
    • (1999) Biophys J , vol.76 , pp. 469-477
    • Scaduto Jr., R.C.1    Grofyohann, L.W.2
  • 26
    • 0037023692 scopus 로고    scopus 로고
    • Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: A survey of four fuel secretagogues
    • Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB (2002) Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. J Biol Chem 277:11746-11755
    • (2002) J Biol Chem , vol.277 , pp. 11746-11755
    • Antinozzi, P.A.1    Ishihara, H.2    Newgard, C.B.3    Wollheim, C.B.4
  • 27
    • 0023645786 scopus 로고
    • Myeloperoxidase-mediated damage to the succinate oxidase system of Escherichia coli. Evidence for selective inactivation of the dehydrogenase component
    • Rosen H, Rakita RM, Waltersdorph AM, Klebanoff SJ (1987) Myeloperoxidase-mediated damage to the succinate oxidase system of Escherichia coli. Evidence for selective inactivation of the dehydrogenase component. J Biol Chem 262:15004-15010
    • (1987) J Biol Chem , vol.262 , pp. 15004-15010
    • Rosen, H.1    Rakita, R.M.2    Waltersdorph, A.M.3    Klebanoff, S.J.4
  • 29
    • 0036326235 scopus 로고    scopus 로고
    • Differences between mouse and rat pancreatic islets: Succinate responsiveness, malic enzyme, and anaplerosis
    • MacDonald MJ (2002) Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis. Am J Physiol Endocrinol Metab 283:E302-E310
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • MacDonald, M.J.1
  • 30
    • 0037474212 scopus 로고    scopus 로고
    • Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets
    • Li C, Najafi H, Daikhin Y et al (2003) Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. J Biol Chem 278:2853-2858
    • (2003) J Biol Chem , vol.278 , pp. 2853-2858
    • Li, C.1    Najafi, H.2    Daikhin, Y.3
  • 31
    • 0036787462 scopus 로고    scopus 로고
    • Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells
    • McDaniel ML, Marshall CA, Pappan KL, Kwon G (2002) Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes 51:2877-2885
    • (2002) Diabetes , vol.51 , pp. 2877-2885
    • McDaniel, M.L.1    Marshall, C.A.2    Pappan, K.L.3    Kwon, G.4
  • 32
    • 0027154077 scopus 로고
    • Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters
    • Melloul D, Ben-Neriah Y, Cerasi E (1993) Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci U S A 90:3865-3869
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 3865-3869
    • Melloul, D.1    Ben-Neriah, Y.2    Cerasi, E.3
  • 33
    • 0030447883 scopus 로고    scopus 로고
    • Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
    • Marshak S, Totary H, Cerasi E, Melloul D (1996) Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci U S A 93:15057-15062
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 15057-15062
    • Marshak, S.1    Totary, H.2    Cerasi, E.3    Melloul, D.4
  • 34
    • 0035431017 scopus 로고    scopus 로고
    • IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal with type 2 diabetes
    • Leibowitz G, Ferber S, Apelqvist A et al (2001) IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal with type 2 diabetes. Diabetes 50:1799-1806
    • (2001) Diabetes , vol.50 , pp. 1799-1806
    • Leibowitz, G.1    Ferber, S.2    Apelqvist, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.