Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: Plant metabolic engineering comes of age

Physiologia Plantarum

Volumn 126, Issue 3, 2006, Pages 398-406

  Napier, Johnathan A ^a   Haslam, Richard ^a   Venegas Caleron, Monica ^a   Michaelson, Louise V ^a   Beaudoin, Frédéric ^a   Sayanova, Olga ^a  

^a ROTHAMSTED RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEALTH CARE; METABOLISM; NUTRITION; OILS AND FATS; PLANTS (BOTANY);

FISH OILS; METABOLIC ENGINEERING; TRANSGENIC PLANTS;

FATTY ACIDS;

EID: 33644747408     PISSN: 00319317     EISSN: 13993054     Source Type: Journal    
DOI: 10.1111/j.1399-3054.2006.00603.x     Document Type: Review

References (41)

1. 22 polyunsaturated fatty acids? Eur J Lipid Sci Technol 103 106 113
2. Abbadi A Domergue F Bauer J Napier JA Welti R Zahringer U Cirpus P Heinz E 2004 Biosynthesis of very-long-chain polyunsaturated fatty acids in transgenic oilseeds: constraints on their accumulation Plant Cell 16 2734 2748
3. Beaudoin F Napier JA 2004 Biosynthesis and compartmentalisation of triacyglycerol in higher plants Topics Curr Genet 6 267 287
4. Beaudoin F Michaelson LV Hey SJ Lewis MJ Shewry PR Sayanova O Napier JA 2000 Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway Proc Natl Acad Sci USA 97 6421 6426
5. Beaudoin F Gable K Sayanova O Dunn T Napier JA 2002 A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase J Biol Chem 277 11481 11488
6. Burr ML Fehily AM Gilbert JF Rogers S Holliday RM Sweetnam PM Elwood PC Deadman NM 1989 Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART) Lancet 2 757 761
7. Domergue F Abbadi A Ott C Zank TK Zahringer U Heinz E 2003 Acyl carriers used as substrates by the desaturases and elongases involved in very long-chain polyunsaturated fatty acids biosynthesis reconstituted in yeast J Biol Chem 278 35115 35126
8. Domergue F Abbadi A Heinz E 2005a Relief for fish stocks: oceanic fatty acids in transgenic oilseeds Trends Plant Sci 10 112 111
9. Domergue F Abbadi A Zahringer U Moreau H Heinz E 2005b In vivo-characterisation of the first acyl-CoA Delta6-desaturase from the plant kingdom, the microalga Ostreococcus tauri Biochem J 389 483 490
10. Drexler H Spiekermann P Meyer A Domergue F Zank T Sperling P Abbadi A Heinz E 2003 Metabolic engineering of fatty acids for breeding of new oilseed crops: strategies, problems and first results J Plant Physiol 160 779 802
11. Estruch JJ Carozzi NB Desai N Duck NB Warren GW Koziel MG 1997 Transgenic plants: an emerging approach to pest control Nat Biotechnol 15 137 141
12. Graham IA Cirpus P Rein D Napier JA 2004 The use of very long chain polyunsaturated fatty acids to ameliorate metabolic syndrome: transgenic plants as an alternative sustainable source to fish oils Nutr Bull 29 228 233
13. Green AG 2004 From alpha to omega-producing essential fatty acids in plants Nat Biotechnol 22 680 682
14. Grusak MA 2005 Rice gets a boost from maize Nat Biotechnol 23 429 430
15. Hastings N Agaba M Tocher DR Leaver MJ Dick JR Sargent JR Teale AJ 2001 A vertebrate fatty acid desaturase with Δ5 and Δ6 activities Proc Nat Acad Sci USA 98 14304 14309
16. Kinney AJ Cahoon EB Damude HG Hitz WD Kolar CW Liu Z-B 2004 Production of very long chain polyunsaturated fatty acids in oilseed plants. EI Du Pont de Nemours WO 2004/071467 A2
17. Knutzon DS Thurmond JM Huang Y Chaudhary S Bobik EG Chan GM Kirchner SM Mukerji P 1998 Identification of Δ5-desaturase from Mortierella alpina by heterologous expression in Bakers' yeast and canola J Biol Chem 273 29360 29366
18. Leonard AE Pereira SL Sprecher H Huang YS 2004 Elongation of long-chain fatty acids Prog Lipid Res 43 36 54
19. Metz JG Roessler P Facciotti D Levering C Dittrich F Lassner M Valentine R Lardizabal K Domergue F Yamada A Yazawa K Knauf V Browse J 2001 Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes Science 293 290 293
20. Meyer A Kirsch H Domergue F Abbadi A Sperling P Bauer J Cirpus P Zank TK Moreau H Roscoe TJ Zahringer U Heinz E 2004 Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis J Lipid Res 45 1899 1909
21. Millar AA Wrischer M Kunst L 1998 Accumulation of very-long-chain fatty acids in membrane glycerolipids is associated with dramatic alterations in plant morphology Plant Cell 10 1889 1902
22. Nakane S Tanaka T Satouchi K Kobayashi Y Waku K Sugiura T 2000 Occurrence of a novel cannabimimetic molecule 2-sciadonoylglycerol (2-eicosa-5′, 11′,14′-trienoylglycerol) in the umbrella pine Sciadopitys verticillata seeds Biol Pharm Bull 23 758 761
23. 5 fusion desaturases in the synthesis of polyunsaturated fatty acids Prostaglandins Leukot Essent Fatty Acids 68 135 143
24. Napier JA Sayanova O Qi B Lazarus CM 2004a Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants Lipids 39 1067 1075
25. Napier JA Beaudoin F Michaelson LV Sayanova O (2004b) The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering Biochimie 86 785 92
26. Nugent AP 2004 The metabolic syndrome Nutr Bull 29 36 43
27. Parker-Barnes JM Das T Bobik E Leonard AE Thurmond JM Chaung LT Huang YS Mukerji P 2000 Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids Proc Natl Acad Sci USA 97 8284 8289
28. Pereira SL Leonard AE Huang YS Chuang LT Mukerji P 2004 Identification of two novel microalgal enzymes involved in the conversion of the omega 3-fatty acid, eicosapentaenoic acid (EPA), to docosahexaenoic acid (DHA) Biochem J 384 357 366
29. Qi B Fraser T Mugford S Dobson G Sayanova O Butler J Napier JA Lazarus CM 2004 Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants Nat Biotechnol 22 739 745
30. Qiu X 2003 Biosynthesis of docosahexaenoic acid (DHA, 22: 6-4, 7,10,13,16,19): two distinct pathways Prostaglandins Leukot Essent Fatty Acids 68 181 186
31. Renz A Heinz E Abbadi A Domergue F Zank T 2004 Methods for the production of polyunsaturated fatty acids. BASF Plant Science GmbH WO 2004/076617 A3
32. Robert S Singh S Zhou X-R Petrie JR Blackburn SI Mansour PM Nichols PD Liu Q Green AG 2005 Metabolic engineering of arabidopsis to produce nutritionally important DHA in seed oil Funct Plant Biol 32 473 479
33. Sayanova O Napier JA 2004 Eicosapentaenoic acid: biosynthetic routes and the potential for synthesis in transgenic plants Phytochemistry 65 147 158
34. 6-desaturated fatty acids in transgenic tobacco Proc Natl Acad Sci USA 94 4211 4216
35. Singh SP Zhou XR Liu Q Stymne S Green AG 2005 Metabolic engineering of new fatty acids in plants Curr Opin Plant Biol 8 197 203
36. Sperling P Ternes P Zank TK Heinz E 2003 The evolution of desaturases Prostaglandins Leukot Essent Fatty Acids 68 73 95
37. Thelen JJ Ohlrogge JB 2002 Metabolic engineering of fatty acid biosynthesis in plants Metab Eng 4 12 21
38. Tonon T Qing R Harvey D Li Y Larson TR Graham IA 2005a Identification of a long-chain polyunsaturated fatty acid acyl-coenzyme A synthetase from the diatom Thalassiosira pseudonana Plant Physiol 138 402 408
39. Tonon T Sayanova O Michaelson LV Qing R Harvey D Larson TR Li Y Napier JA Graham IA 2005b Fatty acid desaturases from the microalga Thalassiosira pseudonana FEBS J 272 3401 3412
40. Tucker G 2003 Nutritional enhancement of plants Curr Opin Biotechnol 14 221 225
41. Wu G Truksa M Datla N Vrinten P Bauer J Zank T Cirpus P Heinz E Qiu X 2005 Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants Nat Biotechnol 23 1013 1017