Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 15, 2000, Pages 8284-8289

  Parker Barnes, Jennifer M ^a   Das, Tapas ^a   Bobik, Emil ^a   Leonard, Amanda E ^a   Thurmond, Jennifer M ^a   Chaung, Lu Te ^a   Huang, Yung Sheng ^a   Mukerji, Pradip ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL ENZYME; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ARTICLE; BIOSYNTHESIS; ENZYME ISOLATION; ENZYME MECHANISM; FATTY ACID SYNTHESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHYTOCHEMISTRY; PRIORITY JOURNAL;

ACETYLTRANSFERASES; AMINO ACID SEQUENCE; BASE SEQUENCE; DNA, FUNGAL; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; GAMMA-LINOLENIC ACID; MOLECULAR SEQUENCE DATA; MORTIERELLA; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0034682508     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.15.8284     Document Type: Article

References (20)

1. Smith, W. L. & Borgeat, P. (1985) in Biochemistry of Lipids and Membranes, eds. Vance, D. E. & Vance, J. E. (Benjamin/Cummings, Menlo Park, CA), pp. 325-360.
2. Horrobin, D. F. (1990) Rev. Contemp. Pharmacother. 1, 1-45.
3. Horrobin, D. F. (1997) Diabetes 46, Suppl. 2, S90-S93.
4. Carlson, S. E., Werkman, S. H., Peeples, J. M., Cooke, R. J. & Tolley, E. A. (1993) Proc. Natl. Acad. Sci. USA. 90, 1073-1077.
5. Birch, E. E., Hoffman, D. R., Uauy, R., Birch, D. G. & Prestidge, C. (1998) Pediatr. Res. 44, 201-209.
6. Gunstone, F. D., Harwood, J. L. & Padley, F. B. (1994) in The Lipid Handbook (Chapman & Hall, London), pp. 47-223.
7. Napier, J. A., Michaelson, L. V. & Stobart, A. K. (1999) Curr. Opin. Plant Biol. 2, 123-127.
8. Lassner, M. W., Lardizabal, K. & Metz, J. G. (1996) Plant Cell 8, 281-292.
9. Millar, A. A. & Kunst, L. (1997) Plant J. 12, 121-131.
10. Oh, C. S., Toke D. A., Mandela S. & Martin C. E. (1997) J. Biol. Chem. 272, 17376-17384.
11. Bajpai, P. K., Bajpai, P. & Ward, O. P. (1991) J. Ind. Microbiol. 8, 179-185.
12. Chapkin, R. S. & Coble, K. J. (1991) Biochim. Biophys. Acta 1085, 365-370.
13. Huang, Y. S., Chaudhary S., Thurmond, J. M., Bobik, E. G. Jr., Yuan, L., Chan, G. M., Kirchner, S. J., Mukerji, P. & Knutzon, D. S. (1999) Lipid Res. 34, 649-659.
14. Knutzon, D. S., Thurmond, J. M., Huang, Y. S., Chaudhary, S., Bobik, E. G., Jr., Chan, G. M., Kirchner, S. J. & Mukerji, P. (1998) J. Biol. Chem. 273, 29360-29366.
15. Michaelson, L. V., Lazarus, C. M., Griffiths, G., Napier, J. A. & Stobart A. K. (1998) J. Biol. Chem. 273, 19055-19059.
16. Hoveland, P., Flick, J., Johnston, M. & Sclafani, R. A. (1989) Gene 83, 57-64.
17. Ausubul, F., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (1995) in Short Protocols in Molecular Biology (Wiley, New York), pp. 4.8-4.9.
18. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) in Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, New York), pp. 8.3-8.32.
19. Gietz, R. D. & Schiestl, R. H. (1995) Methods Mol. Cell. Biol. 5, 255-269.
20. Hoffman, C. & Winston, F. (1987) Gene 57, 267.