Metabolic engineering of fatty acid biosynthesis in plants

Metabolic Engineering

Volumn 4, Issue 1, 2002, Pages 12-21

  Thelen, Jay ^a   Ohlrogge, John ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0036338519     PISSN: 10967176     EISSN: None     Source Type: Journal    
DOI: 10.1006/mben.2001.0204     Document Type: Article

References (65)

1. Genetic engineering of plant lipids
2. Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids
3. Accumulation of ricinoleic, lesquerolic, and denispolic acids in seeds of transgenic Arabidopsis plants that express a fatty acid hydroxylase cDNA from castor bean
4. Biosynthetic origin of conjugated double bonds: Production of fatty acid components of high-value drying oils in transgenic soybean embryos
5. Delta-6-hexadecenoic acid is synthesized by the activity of a soluble delta 6 palmitoyl-acyl carrier protein desaturase in Thunbergia alata endosperm
6. Production of fatty acid components of meadowfoam oil in somatic soybean embryos
7. Apparent role of phosphatidylcholine in the metabolism of petroselinic acid in developing Umbelliferae endosperm
8. A determinant of substrate specificity predicted from the acyl-acyl carrier protein desaturase of developing cat's claw seed
9. Substrate-dependent mutant complementation to select fatty acid desaturase variants for metabolic engineering of plant seed oils
10. Expression of a coriander desaturase results in petroselinic acid production in transgenic tobacco
11. Medium chain acyl-ACP hydrolysis activities of developing oilseeds
12. Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli
13. KAS IV: A ketoacyl-ACP synthase from Cuphea sp. is a medium chain specific condensing enzyme
14. Production of high levels of 8:0 and 10:0 fatty acids in transgenic canola by overexpression of Ch FatB2, a thioesterase cDNA from Cuphea hookeriana
15. Overexpression of 3-ketoacyl acyl carrier protein synthase IIIs in plants reduces the rate of lipid synthesis
16. Specificities of the acyl-acyl carrier protein (ACP) thioesterase and glycerol-3-phosphate acyltransferase for octadecenoyl-ACP isomers
17. Accumulation of palmitate in Arabidopsis mediated by the acyl-acyl carrier protein thioesterase FATB1
18. Utilization of petroselinate (C 18:1 delta 6) by glycerol acylation enzymes in microsomal preparations of developing embryos of carrot (Daucus carota L.), safflower (Carthamus tinctorius L.), and oil rape (Brassica napus L.)
19. Expression of lauroyl-acyl carrier protein thioesterase in Brassica napus seeds induces pathways for both fatty acid oxidation and biosynthesis and implies a set-point for triacylglycerol accumulation
20. Microarray analysis of developing Arabidopsis seeds
21. Soybeans pace boost in oilseed production
22. Characterization of acyl-ACP thioesterases of mangosteen (Garcinia mangostana) seed and high levels of stearate production in transgenic canola
23. Economic aspects of transgenic crops which produce novel products
24. Types of dietary fat and risk of coronary heart disease: A critical review
25. Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight
26. Palmitoyl-acyl carrier protein (ACP) thioesterase and the evolutionary origin of plant acyl-ACP thioesterases
27. Utility of the Arabidopsis FAE1 and yeast SLC1-1 genes for improvements in erucic acid and oil content in rapeseed
28. Development of genetically engineered soybean oils for food applications
29. Lysophosphatidic acid acyltransferase from coconut endosperm mediates the insertion of laurate at the sn-2 position of triacylglycerols in lauric rapeseed oil and can increase total laurate levels
30. Modification of Brassica seed oil by antisense expression of a stearoyl-acyl carrier protein desaturase gene
31. Purification of a jojoba embryo wax synthase, cloning of its cDNA, and production of high levels of wax in seeds of transgenic Arabidopsis
32. Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation
33. A Cuphea beta-ketoacyl-ACP synthase shifts the synthesis of fatty acids towards shorter chains in Arabidopsis seeds expressing Cuphea FatB thioesterases
34. Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques
35. An unusual seed specific 3-ketoacyl-ACP synthase associated with the biosynthesis of petroselinic acid in coriander
36. Purification of a jojoba embryo fatty acyl-coenzyme A reductase and expression of its cDNA in high erucic acid rapeseed
37. High-oleate oilseeds fail to develop at low temperature
38. Arabidopsis requires polyunsaturated lipids for low-temperature survival
39. Design of new plant products: Engineering of fatty acid metabolism
40. Subcellular localization of acyl carrier protein in leaf protoplasts of Spinacia oleracea
41. Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis
42. Specific acyl-ACP thioesterase implicated in medium-chain fatty acid production in immature cotyledons of Umbellularia californica
43. In vivo pools of free and acylated acyl carrier proteins in spinach: Evidence for sites of regulation of fatty acid biosynthesis
44. Regulation of plant fatty acid biosynthesis: Analysis of acyl-CoA and acyl-acyl carrier protein substrate pools in spinach and pea chloroplast
45. Expression of a cyanobacterial delta-6 desaturase gene results in gamma-linolenic acid production in transgenic plants
46. Targeting of the Arabidopsis homomeric acety-coenzyme A carboxylase to plastids of rapeseeds
47. Stromal concentrations of coenzyme A and its esters are insufficient to account for rates of chloroplast fatty acid synthesis: Evidence for substrate channelling within the chloroplast fatty acid synthase
48. Biosynthesis of triacylglycerol in Thunbergia alata: Additional evidence for involvement of phosphatidylcholine in unusual monoenoic oil production
49. Metabolic engineering of fatty acid biosynthesis
50. Stearoyl-acyl carrier protein and unusual acyl-acyl carrier protein desaturase activities are differentially influenced by ferredoxin
51. Feedback inhibition of fatty acid synthesis in tobacco suspension cells
52. Antisense expression and overexpression of biotin carboxylase in tobacco leaves
53. Inhibition of polyunsaturated fatty acid accumulation in plants expressing a fatty acid epoxygenase
54. Malate- and pyruvate-dependent fatty acid synthesis in leucoplasts from developing castor endosperm
55. Production of hydroxy fatty acids in the seeds of Arabidopsis thaliana
56. High-oleic acid Australian Brassica napus and B. juncea varieties produced by co-suppression of endogenous delta-12 desaturases
57. Isoforms of acyl carrier protein involved in seed-specific fatty acid synthesis
58. Production of beneficial dietary omega-3 and omega-6 fatty acids in transgenic canola
59. Unusual fatty acids
60. Developmental specific expression and organelle targeting of the Escherichia coli fabD gene, encoding malonyl coenzyme A-acyl carrier protein transacylase in transgenic rape and tobacco seeds
61. Genetic engineering of a quantitative trait: Metabolic and genetic parameters influencing the accumulation of laurate in rapeseed
62. Broad-range and binary-range acyl-acyl carrier protein thioesterases suggest an alternative mechanism for medium-chain production in seeds
63. Variations in the biosynthesis of seed storage lipids
64. Fatty acid biosynthesis redirected to medium chains in transgenic oilseed plants
65. Modification of seed oil content and acyl composition in the Brassicaceae by expression of a yeast sn-2-acyltransferase gene