Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells

Biochemical and Biophysical Research Communications

Volumn 327, Issue 4, 2005, Pages 1028-1035

  Akimoto, Miho ^a   Niikura, Mamoru ^a   Ichikawa, Masami ^a   Yonekawa, Hiromichi ^b   Nakada, Kazuto ^a   Honma, Yoshio ^c   Hayashi, Jun Ichi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

Carcinogen; Malignant transformation; mtDNA mutations; mtDNA replacement; mtDNA less mouse cells

Indexed keywords

CELL NUCLEUS DNA; MITOCHONDRIAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; GENE EXPRESSION; GENETIC MARKER; HAPLOTYPE; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY FUNCTION; TUMOR GROWTH;

ANIMALS; BASE SEQUENCE; CARCINOGENS; CELL RESPIRATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHIMERISM; DNA; DNA, MITOCHONDRIAL; FIBROBLASTS; GENOME; MALE; METHYLCHOLANTHRENE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS; PHENOTYPE;

MUS MUSCULUS;

EID: 12344268864     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.12.105     Document Type: Article

References (25)

1. J.A. Allen, and M.M. Coombs Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA Nature 287 1980 244 245
2. J.M. Backer, and I.B. Weinstein Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo(a)pyrene Science 209 1980 297 299
3. J.W. Shay, and H. Werbin Are mitochondrial DNA mutations involved in the carcinogenic process? Mutat. Res. 186 1987 149 160
4. K. Polyak, Y. Li, H. Zhu, C. Lengauer, J.K.V. Willson, S.D. Markowitz, M.A. Trush, K.W. Kinzler, and B. Vogelstein Somatic mutations of the mitochondrial genome in human colorectal tumors Nat. Genet. 20 1998 291 293
5. M.S. Fliss, H. Usadel, O.L. Caballero, L. Wu, M.R. Buta, S.M. Eleff, J. Jen, and D. Sidransky Facile detection of mitochondrial DNA mutations in tumors and bodily fluids Science 287 2000 2017 2019
6. J.B. Jones, J.J. Song, P.M. Hempen, G. Parmigiani, R.H. Hruban, and S.E. Kern Detection of mitochondrial DNA mutations in pancreatic cancer offers a massive advantage over detection of nuclear DNA mutations Cancer Res. 61 2001 1299 1304
7. V.W. Liu, H.H. Shi, A.N. Cheung, P.M. Chiu, T.W. Leung, P. Nagley, L.C. Wong, and H.Y. Ngan High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas Cancer Res. 61 2001 5998 6001
8. D.J. Tan, R.K. Bai, and L.J. Wong Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer Cancer Res. 62 2002 972 976
9. K. Inoue, S. Ito, D. Takai, A. Soejima, H. Shisa, J.-B. LePecq, E. Segal-Bendirdjian, Y. Kagawa, and J.-I. Hayashi Isolation of mtDNA-less mouse cell lines and their application for trapping mouse synaptosomal mtDNA with deletion mutations J. Biol. Chem. 272 1997 15510 15555
10. C.A. Raznikoff, J.S. Bertram, D.W. Brankow, and C. Heidelberger Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division Cancer Res. 33 1973 3239 3249
11. H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Beroud, J. Demont, R. Bouvier, H. Schagger, and C. Godinot Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma Carcinogenesis 23 2002 759 768
12. D.C. Wallace Mitochondrial diseases in man and mouse Science 283 1999 1482 1488
13. T.M. Horton, J.A. Petros, A. Heddi, J. Shoffner, A.E. Kaufman, S.D. Graham Jr., T. Gramlich, and D.C. Wallace Novel mitochondrial DNA deletion found in a renal cell carcinoma Genes Chromosomes Cancer 15 1996 95 101
14. V. Máximo, P. Soares, R. Seruca, and M. Sobrinho-Simões Comments on: mutations in mitochondrial control region DNA in gastric tumors of Japanese patients Eur. J. Cancer 35 1999 1407 1408
15. H.-C. Lee, P.-H. Yin, T-N. Yu, Y.-D. Chang, W.-C. Hsu, S.-Y. Kao, C.-W. Chi, T.-Y. Liu, Y.-H. Wei, Accumulation of mitochondrial DNA deletions in human oral tissues: effects of betel quid chewing and oral cancer, Mutat. Res. 493 (2001) 67-74
16. K. Inoue, K. Nakada, A. Ogura, K. Isobe, Y. Goto, I. Nonaka, and J.-I. Hayashi Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes Nat. Genet. 26 2000 176 181
17. K. Nakada, K. Inoue, T. Ono, K. Isobe, A. Ogura, Y. Goto, I. Nonaka, and J.-I. Hayashi Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA Nat. Med. 7 2001 934 939
18. J.-I. Hayashi, H. Werbin, and J.W. Shay Effects of normal human fibroblast mitochondrial DNA on segregation of HeLaTG mitochondrial DNA and on tumorigenicity of HeLaTG cells Cancer Res. 46 1986 4001 4006
19. J.-I. Hayashi, H. Yonekawa, and Y. Tagashira Nuclear but not mitochondrial genome involvement in 3-methylcholanthrene-induced expression of tumorigenicity in mouse somatic cells Cancer Res. 49 1989 4715 4720
20. H.A. Coller, K. Khrapko, N.D. Bodyak, E. Nekhaeva, P. Herrero-Jimenez, and W.G. Thilly High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection Nat. Genet. 28 2001 147 150
21. P.F. Chinnery, D.C. Samuels, J. Eslon, and D.M. Turnbull Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism? Lancet 360 2002 1323 1325
22. J.-I. Hayashi, H. Yonekawa, J. Murakami, Y. Tagashira, O.M. Pereira-Smith, and J.W. Shay Mitochondrial genomes in intraspecies mammalian cell hybrids display codominant or dominant/recessive behavior Exp. Cell Res. 172 1987 218 227
23. J.W. Shay, and S. Ishii Unexpected nonrandom mitochondrial DNA segregation in human cell hybrids Anticancer Res. 10 1990 279 284
24. H. Kaneda, J.-I. Hayashi, S. Takahama, C. Taya, K. Fischer Lindahl, and H. Yonekawa Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis Proc. Natl. Acad. Sci. USA 92 1995 4542 4546
25. H. Shitara, J.-I. Hayashi, S. Takahama, H. Kaneda, and H. Yonekawa Maternal inheritance of mouse mtDNA in interspecific hybrids: segregation of the leaked paternal mtDNA followed by the prevention of subsequent paternal leakage Genetics 148 1998 851 857