Identification of peptide ligands to the chemokine receptor CCR5 and their maturation by gene shuffling

Molecular Immunology

Volumn 43, Issue 10, 2006, Pages 1573-1578

  Vyroubalova, Eva Cachin ^a   Hartley, Oliver ^b   Mermod, Nicolas ^a   Fisch, Igor ^a,c  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c Selexis SA   (Switzerland)

Author keywords

CCR5 receptor; Gene shuffling; HIV; In vitro maturation; Peptide; Phage display

Indexed keywords

CHEMOKINE RECEPTOR CCR5; LIGAND; PEPTIDE LIBRARY;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ASSAY; CELL FUSION; CONTROLLED STUDY; EXON; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; TARGET CELL;

ANIMALS; ANTI-HIV AGENTS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DIRECTED MOLECULAR EVOLUTION; DNA SHUFFLING; DRUG DESIGN; HUMANS; LIGANDS; MEMBRANE FUSION; PEPTIDE LIBRARY; PEPTIDES; RECEPTORS, CCR5;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33644519283     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2005.09.025     Document Type: Article

References (19)

1. L.A. Cooley, and S.R. Lewin HIV-1 cell entry and advances in viral entry inhibitor therapy J. Clin. Virol. 26 2003 121 132
2. R. Eri, J.R. Jonsson, N. Pandeya, D.M. Purdie, A.D. Clouston, N. Martin, D. Duffy, E.E. Powell, J. Fawcett, T.H. Florin, and G.L. Radford-Smith CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis Genes Immun. 5 2004 444 450
3. Y. Feng, C.C. Broder, P.E. Kennedy, and E.A. Berger HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane G protein-coupled receptor Science 272 1996 872 877
4. I. Fisch, R.E. Kontermann, R. Finnern, O. Hartley, A.S. Soler-Gonzalez, A.D. Griffiths, and G. Winter A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage Proceedings of the National Academy of Sciences of the United States of America, vol. 93 1996 7761 7766
5. R. Gade-Andavolu, D.E. Comings, J. MacMurray, M. Rostamkhani, L.S. Cheng, W.W. Tourtellotte, and L.A. Cone Association of CCR5 delta32 deletion with early death in multiple sclerosis Genet. Med. 6 2004 126 131
6. H. Gron, and R. Hyde-DeRuyscher Peptides as tools in drug discovery Curr. Opin. Biotechnol. 3 2000 636 645
7. O. Hartley, K. Dorgham, D. Perez-Bercoff, F. Cerini, A. Heimann, H. Gaertner, R.E. Offord, G. Pancino, P. Debre, and G. Gorochov Human immunodeficiency virus type 1 entry inhibitors selected on living cells from a library of phage chemokines J. Virol. 77 2003 6637 6644
8. P.J. Klasse, M.M. Rosenkilde, N. Signoret, A. Pelchen-Matthews, T.W. Schwartz, and M. Marsh CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection J. Virol. 73 1999 7453 7466
9. D.E. Mosier, G.R. Picchio, R.J. Gulizia, R. Sabbe, P. Poignard, L. Picard, R.E. Offord, D.A. Thompson, and J. Wilken Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants J. Virol. 73 1999 3544 3550
10. M. Oki, H. Ohtani, Y. Kinouchi, E. Sato, S. Nakamura, T. Matsumoto, H. Nagura, O. Yoshie, and T. Shimosegawa Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response? Lab. Invest. 85 2005 137 145
11. O. Pleskoff, C. Treboute, A. Brelot, N. Heveker, M. Seman, and M. Alizon Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry Science 276 1997 1874 1878
12. V. Pokorny, F. McQueen, S. Yeoman, M. Merriman, A. Merriman, A. Harrison, J. Highton, and L. McLean Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis Ann. Rheum. Dis. 64 2005 487 490
13. A.E. Proudfoot, R. Buser, F. Borlat, S. Alouani, D. Soler, R.E. Offord, J.M. Schroder, C.A. Power, and T.N. Wells Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors J. Biol. Chem. 274 1999 32478 324885
14. S.C. Robinson, K.A. Scott, J.L. Wilson, R.G. Thompson, A.E. Proudfoot, and F.R. Balkwill A chemokine receptor antagonist inhibits experimental breast tumor growth Cancer Res. 63 2003 8360 8365
15. S. Rusconi, A. Scozzafava, A. Mastrolorenzo, and C.T. Supuran New advances in HIV entry inhibitors development Curr. Drug Targets Infect. Disord. 4 2004 339 355
16. N. Signoret, A. Pelchen-Matthews, M. Mack, A.E. Proudfoot, and M. Marsh Endocytosis and recycling of the HIV coreceptor CCR5 J. Cell Biol. 151 2000 1281 1294
17. P. Srivastava, P.J. Helms, D. Stewart, M. Main, and G. Russell Association of CCR5Delta32 with reduced risk of childhood but not adult asthma Thorax 58 2003 222 226
18. T.S. Stantchev, and C.C. Broder Human immunodeficiency virus type-1 and chemokines: beyond competition for common cellular receptors Cytokine Growth Factor Rev. 12 2001 219 243
19. P. Waterhouse, A.D. Griffiths, K.S. Johnson, and G. Winter Combinatorial infection and in vivo recombination: a strategy for making large phage antibody repertoires Nucleic Acids Res. 21 1993 2265 2266