Accessing rare activities from random RNA sequences: The importance of the length of molecules in the starting pool

Chemistry and Biology

Volumn 4, Issue 10, 1997, Pages 767-774

  Sabeti, Pardis C ^a   Unrau, Peter J ^a   Bartel, David P ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

In vitro selection; Random sequence; Ribozymes; RNA folding; SELEX

Indexed keywords

EID: 0031259915     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(97)90315-X     Document Type: Article

References (19)

1. Williams, K.P. & Bartel, D.P. (1996). In vitro selection of catalytic RNA. In Catalytic RNA. (Eckstein, F. & Lilley, D.M.J., eds), pp. 367-381, Springer-Verlag: Berlin Heidelberg.
2. Breaker, R.R. (1997). In vitro selection of catalytic polynucleotides. Chem. Rev. 97, 371-390.
3. Gold, L., Polisky, B., Uhlenbeck, O. & Yarus, M. (1995). Diversity of oligonucleotide functions, Annu. Rev. Biochem. 64, 763-797.
4. Osborne, S.E. & Ellington, A.D. (1997). Nucleic acid selection and the challenge of combinatorial chemistry. Chem. Rev. 97, 349-370.
5. Connell, G.J., Illangesekare, M. & Yarus, M. (1993). Three small ribooligonucleotides with specific arginine sites. Biochemistry 32, 5497-5502.
6. Bartel, D.P. & Szostak, J.W. (1993). Isolation of new ribozymes from a large pool of random sequences. Science 261, 1411-1418.
7. 20-fold aptamer library amplification without gel purification. Nucleic Acids Res. 21, 4410.
8. Schultes, E., Hraber, P.T. & LaBean, T.H. (1997). Global similarities in nucleotide base composition among disparate functional classes of single-stranded RNA imply adaptive evolutionary convergence. RNA 3, 792-806.
9. Ekland, E.H. & Bartel, O.P. (1995). The secondary structure and sequence optimization of an RNA ligase ribozyme. Nucleic Acids Res. 23, 3231-3238.
10. Ekland, E.H., Szostak, J.W. & Bartel, D.P. (1995). Structurally complex and highly active RNA ligases derived from random RNA sequences. Science 269, 364-370.
11. Sassanfar, M. & Szostak, J.W. (1993). An RNA motif that binds ATP. Nature 364, 550-553.
12. Famulok, M. (1994). Molecular recognition of amino acids by RNA-aptamers: an L-citrulline binding RNA motif and its evolution into an L-arginine binder. J. Am. Chem. Soc. 116, 1698-1706.
13. Uhlenbeck, O.C. (1995). Keeping RNA happy. RNA 1, 4-6.
14. Herschlag, D. (1995). RNA chaperones and the RNA folding problem. J. Biol. Chem. 270, 20871-20874.
15. Lorsch, J.R. & Szostak, J.W. (1994). In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature 371, 31-36.
16. Schneider, D., Tuerk, C. & Gold, L. (1992). Selection of high affinity RNA ligands to the bacteriophage R17 coat protein. J. Mol. Biol. 228, 862-869.
17. Bartel, D.P., Zapp, M.L., Green, M.R. & Szostak, J.W. (1991). HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell 67, 529-536.
18. Battiste, J.L., Mao, H., Rao, N.S., Tan, R., Muhandiram, D.R., Kay, L.E., Frankel, A.D. & Williamson, J.R. (1996). α Helix-RNA major groove recognition in HIV-1 Rev peptide-RRE RNA complex. Science 273, 1547-1551.
19. McKay, D.B. (1996). Three-Dimensional Structure of the Hammerhead Ribozyme. In Catalytic RNA. (Eckstein, F. & Lilley, D.M.J., eds), pp. 161-172, Springer-Verlag: Berlin Heidelberg.