Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway

Toxicological Sciences

Volumn 90, Issue 1, 2006, Pages 73-86

  Chao, Jui I ^a   Hsu, Shih Hsin ^a   Tsou, Tsui Chun ^b  

^a TZU CHI UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Apoptosis; Arsenite; Mitosis; p53; Securin; Separase

Indexed keywords

ARSENIC TRIOXIDE; CYCLIN B1; CYCLIN DEPENDENT KINASE; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; REGULATOR PROTEIN; SECURIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL SURVIVAL; CELL VIABILITY; CHEMICAL CARCINOGENESIS; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM CELL; GENE MUTATION; GENETIC SUSCEPTIBILITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; MOUSE; NONHUMAN; NULL CELL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTO ONCOGENE; SISTER CHROMATID; VASCULAR ENDOTHELIUM; WILD TYPE;

ANIMALS; APOPTOSIS; ARSENITES; CARRIER PROTEINS; CDC2 PROTEIN KINASE; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; CYCLIN B; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; EPITHELIAL CELLS; MICE; MITOSIS; SISTER CHROMATID EXCHANGE; SODIUM COMPOUNDS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 33144489234     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfj070     Document Type: Article

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