Treatment of acute promyelocytic leukemia with arsenic trioxide: Clinical and basic studies

Leukemia and Lymphoma

Volumn 42, Issue 6, 2001, Pages 1265-1273

  Zhao, Wei Li ^a   Chen, Sai Juan ^a   Shen, Yang ^a   Xu, Lan ^a   Cai, Xun ^a   Chen, Guo Qiang ^a   Shen, Zhi Xiang ^a   Chen, Zhu ^a   Wang, Zhen Yi ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Acute promyelocytic leukemia; APL; Arsenic trioxide; Clinical studies

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; ONCOPROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR;

APOPTOSIS; ARTHRALGIA; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG POTENTIATION; GASTROINTESTINAL DISEASE; HUMAN; LEUKEMIA REMISSION; LEUKEMOGENESIS; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; SKIN MANIFESTATION;

APOPTOSIS; ARSENICALS; CELL DIFFERENTIATION; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MITOCHONDRIA; NEOPLASM PROTEINS; ONCOGENE PROTEINS, FUSION; OXIDES; RECOMBINANT FUSION PROTEINS; SULFHYDRYL COMPOUNDS;

EID: 0035691526     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190127514     Document Type: Article

References (36)

1. "Differentiation and apoptosis induction therapy in acute promyelocytic leukemia"
2. "Retinoic acid regulatory pathways, chromosomal translocations and acute promyelocyte leukemia"
3. "Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia"
4. "Treatment of acute promyelocytic leukemia by AL-1 therapy"
5. 3) in the treatment of acute promyelocytic leukemia (APL): II clinical efficacy and pharmacokinetics in relapsed patients"
6. "Studies on the clinical efficacy and pharmacokinetics of low dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: A comparison with conventional dosage"
7. "Arsenic trioxide-treated 72 cases of acute promyelocytic leukemia"
8. 3 induces NB4 cell apoptosis with downregulation of Bcl-2 PML-RARα/PML proteins"
9. "Seven years' summary report on the treatment of acute promyelocytic leukemia with arsenic trioxide: An analysis of 242 cases"
10. "Us multicenter trial of arsenic trioxide (AT) in acute promyelocytic leukemia (APL)"
11. "Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide"
12. "Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide"
13. "Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: Remission induction, follow-up and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia"
14. "Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts"
15. "The impact of all-trans-retinoic acid on the coagulopathy of acute promyelocytic leukemia"
16. "Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents"
17. "Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukemia"
18. "Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia"
19. "Rearrangement of the retinoic acid receptor alpha and PLZF genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia"
20. "PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia"
21. "The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion"
22. "Fusion of retinoic acid receptor α to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukemia"
23. "The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor α in acute promyelocytic-like leukemia"
24. 3 exerts dose-dependent dual effects on APL cells"
25. "Pathologic, cytogenetic and molecular assessment of acute promyelocytic leukemia patients treated with arsenic trioxide"
26. "Mechanisms of apoptotic cell death"
27. "Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia"
28. "Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system"
29. "Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway"
30. "Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis"
31. "Arsenic induces apoptosis through a c-Jun NH2 terminal kinase-dependent, p53-independent pathway"
32. "Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells"
33. "Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells"
34. "Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arsenic resistant NB4 cells"
35. "Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo"
36. "Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia"