Zinc: The missing link in combating micronutrient malnutrition in developing countries

Proceedings of the Nutrition Society

Volumn 65, Issue 1, 2006, Pages 51-60

  Gibson, Rosalind S ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Deficiency; Developing countries; Malnutrition; Micronutrient; Zinc

Indexed keywords

PHYTATE; TRACE ELEMENT; ZINC;

ACUTE DIARRHEA; BIOAVAILABILITY; CHILD GROWTH; CONFERENCE PAPER; DEVELOPING COUNTRY; DIET SUPPLEMENTATION; FOOD COMPOSITION; HUMAN; MALNUTRITION; NUTRIENT CONTENT; NUTRITIONAL ASSESSMENT; PREVALENCE; RISK ASSESSMENT; RISK FACTOR; UNITED NATIONS; WORLD HEALTH ORGANIZATION; ZINC DEFICIENCY;

DEVELOPING COUNTRIES; DIARRHEA; FOOD, FORTIFIED; HUMANS; MALNUTRITION; NUTRITIONAL REQUIREMENTS; ZINC;

EID: 32944457062     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2005474     Document Type: Conference Paper

References (103)

1. Abrams SA, Mushi A, Hilmers DC, Griffin IJ, Davila P & Allen L (2003) A multinutrient-fortified beverage enhances the nutritional status of children in Botswana. Journal of Nutrition 133, 1834-1840.
2. Adams CL, Hambidge M, Raboy V, Dorsch JA, Sian L, Westcott JL & Krebs NF (2002) Zinc absorption from a low-phytic acid maize. American Journal of Clinical Nutrition 76, 556-559.
3. Aggett PJ & Harries JT (1979) Current status of zinc in health and disease states. Archives of Disease in Childhood 54, 909-917.
4. Alloway BJ (2004) Zinc in Soils and Crop Nutrition. Brussels, Belgium: International Zinc Association.
5. Ash DM, Frongillo EA, Ndosi GD, Latham M & Garcia OP (2003) Randomized efficacy trial of a micronutrient-fortified beverage in primary school children in Tanzania. American Journal of Clinical Nutrition 77, 891-898.
6. Baqui A, Black RE, Arifeen SEI, Yunus MN, Chakraborty J, Ahmed S & Vaughan JP (2002) Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. British Medical Journal 325, 1059-1066.
7. Bates CJ, Evans PH, Dardenne M, Prentice A, Lunn PG, Northrop-Clewes CA et al. (1993) A trial of zinc supplementation in young rural Gambian children. British Journal of Nutrition 69, 243-255.
8. Bentley ME, Caulfield LE, Ram M, Santizo MC, Hurtado E, Rivera JA, Ruel MT & Brown KH (1997) Zinc supplementation affects the activity patterns of rural Guatemalan infants. Journal of Nutrition 27, 1333-1338.
9. Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A et al. (1999) Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group. Journal of Pediatrics 135, 689-697.
10. Bindra GS, Gibson RS & Thompson LU (1986) [Phytate]: [calcium]/[zinc] ratios in Asian immigrant lacto-ovo vegetarian diets and their relationship to zinc nutriture. Nutrition Research 6, 475-483.
11. Brinch-Pedersen H, Sorensen LD & Holm PB (2002) Engineering crop plants: getting a handle on phosphate. Trends in Plant Science 7, 118-125.
12. Brooks WA, Yunus M, Santosham M, Wahed MA, Nahar K, Yeasmin S & Black RE (2004) Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet 363, 1683-1688.
13. Brown KH, Peerson JM, Rivera J & Allen LH (2002) Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition 75, 1062-1071.
14. Castillo-Duran C, Rodriguez A, Venegas G, Alvarez P & Icaza G (1995) Zinc supplementation and growth of infants born small for gestational age. Journal of Pediatrics 127, 206-211.
15. Castillo-Duran C, Vial P & Uauy R (1988) Trace mineral balance during acute diarrhea in infants. Journal of Pediatrics 113, 452-457.
16. Ciliberto MA, Sandige H, Ndekha M, Ashorn P, Briend A, Cilierto H & Manary MJ (2005) Comparison of home-based therapy with ready-to-use therapeutic food with standard therapy in the treatment of malnourished Malawian children: a controlled, clinical effectiveness trial. American Journal of Clinical Nutrition 81, 864-870.
17. Coudray C, Bousset C, Pépin D, Tressol JC, Belanger LF & Rayssiguier Y (1998) Effect of acute ingestion of polyphenol compounds on zinc and copper absorption in the rat: utilisation of stable isotopes and ICP/MS technique. In Polyphenols in Food, pp. 173-177 [R Amadò, H Andersson, S Bardócz and F Serra, editors]. Luxembourg: Office for Official Publications of the European Communities.
18. Davidsson L, Almgren A, Sandström B, Juillerat M-A & Hurrell RF (1996) Zinc absorption in adult humans: the effects of protein sources added to liquid test meals. British Journal of Nutrition 75, 607-613.
19. Davidsson L, Ziegler EE, Kastenmayer P, van Dael P & Barclay D (2004) Dephytinisation of soyabean protein isolate with low native phytic acid content has limited impact on mineral and trace element absorption in healthy infants. British Journal of Nutrition 91, 287-293.
20. Egli I, Davidsson L, Zeder C, Walczyk T & Hurrell R (2004) Dephytinization of a complementary food based on wheat and soy increases zinc, but not copper, apparent absorption in adults. Journal of Nutrition 134, 1077-1080.
21. Erdman JW & Pneros-Schneier AG (1994) Factors affecting nutritive value in processed foods. In Nutrition in Health and Disease, pp. 1569-1578 [ME Shils, JA Olson and M Shile, editors]. Philadelphia, PA: Lea & Febiger.
22. Ezzati M, Loez AD, Rodgers A, Vander Hoorn S & Murray CJL (2002) Selected major risk factors and global and regional burden of disease. Lancet 360, 1347-1360.
23. Ferguson EL, Gibson RS, Opare-Obisaw C, Ounpuu S & Lamba C (1995) Dietary strategies for improving the zinc nutriture of rural Southern Malawian and Ghanaian children. Ecology of Food and Nutrition 34, 33-47.
24. Ferguson EL, Gibson RS, Opare-Obisaw C, Ounpuu S, Thompson LU & Lehrfeld J (1993) The zinc nutriture of preschool children living in two African countries. Journal of Nutrition 123, 1487-1496.
25. Fitzgerald SL, Gibson RS, Quan de Serrano J, Portovcsttrro L, Vasquewz A, de Zepeda E, Lopez-Palacios CY, Thompson LU, Stephen AM & Solomons NW (1993) Trace element intakes and dietary phytate/Zn and Ca x phytate/Zn millimolar ratios of periurban Guatemalan women during the third trimester of pregnancy. American Journal of Clinical Nutrition 57, 195-201.
26. Friel JK, Andrews WL, Matthew JD, Long DR, Cornel AM, Cox M, McKim E & Zerbe GO (1993) Zinc supplementation in very-low-birthweight infants. Journal of Pediatric Gastroenterology and Nutrition 17, 97-104.
27. Frossard E, Bucher M, Mächler F, Mozafar A & Hurrell R (2000) Potential for increasing the content and bioavailability of Fe, Zn and Ca in plants for human nutrition. Journal of the Science in Food and Agriculture 80, 861-879.
28. Fung EB, Ritchie LD, Woodhouse LR, Roehl R & King JC (1997) Zinc absorption in women during pregnancy and lactation: a longitudinal study. American Journal of Clinical Nutrition 66, 80-88.
29. Ganji V & Kies CV (1994) Zinc bioavailability and tea consumption. Plant Foods for Human Nutrition 46, 267-276.
30. Garg HK & Arshad SK (1993) A study of the effect of oral zinc supplementation during pregnancy on pregnancy outcome. Indian Journal of Physiology and Pharmacology 37, 276-284.
31. Gibson RS (1993) Zinc nutrition in developing countries. Nutrition Research Reviews 10, 1-18.
32. Gibson RS & Ferguson EL (1999) An Interactive 24-Hour Recall for Assessing the Adequacy of Iron and Zinc Intakes in Developing Countries. Washington, DC: ILSI Press.
33. Gibson RS & Hotz C (2001) Dietary diversification/modification strategies to enhance micronutrient content and bioavailability of diets in developing countries. British Journal of Nutrition 85, S159-S166.
34. Gibson RS & Huddle JMC (1998) Suboptimal zinc status in pregnant Malawian women: its association with low intakes of poorly available zinc, frequent reproductive cycling and malaria. American Journal of Clinical Nutrition 67, 702-709.
35. Gibson RS, Yeudall F, Drost N, Mtitimuni B & Cullinan T (1998) Dietary interventions to prevent zinc deficiency. American Journal of Clinical Nutrition 68, Suppl., 484S-487S.
36. Gibson RS, Yeudall F, Drost N, Mtitimuni BM & Cullinan TR (2003) Experiences of a community-based dietary intervention to enhance micronutrient adequacy of diets low in animal source foods and high in phytate: a case study in rural Malawian children. Journal of Nutrition 133, 3992S-3999S.
37. Golden MHN (1988) The diagnosis of zinc deficiency. In Zinc in Human Biology, pp. 323-333 [CF Mills, editor]. London: Springer-Verlag.
38. Goldenberg RL, Neggers Y, Cooper RL, Johnston KE, DuBard MB & Hauth JC (1995) The effect of zinc supplementation on pregnancy outcome. Journal of the American Medical Association 274, 463-468.
39. Hambidge KM (1989) Mild zinc deficiency in children. In Zinc in Human Biology, pp. 285-295 [CF Mills, editor]. Berlin: Springer-Verlag.
40. Hambidge KM (1997) Zinc deficiency in children. American Journal of Clinical Nutrition 165, 160-161.
41. Hambidge KM, Hambidge C, Jacobs M & Baum JD (1972) Low levels of zinc in hair, anorexia, poor growth and hypogeusia in children. Pediatric Research 6, 868-874.
42. Hambidge KM, Huffer JW, Raboy V, Grunwald GK, Westcott JL, Sian L, Miller LV, Dorsch JA & Krebs NF (2004) Zinc absorption from low-phytate hybrids of maize and their wild-type isohybrids. American Journal of Clinical Nutrition 79, 1053-1059.
43. Hambidge KM, Krebs NF & Walravens PA (1985) Growth velocity of young children receiving a dietary zinc supplement. Nutrition Research 1, 306-316.
44. Hirsch RS & Sussman MR (1999) Improving nutrient capture from soil by the genetic manipulation of crop plants. Trends in Biotechnology 17, 356-361.
45. Hooda PS, Henry CJK, Seyoum TA, Armstrong LDM & Fowler MB (2004) The potential impact of soil ingestion on human mineral nutrition. Science of the Total Environment 333, 75-87.
46. Hotz C & Brown KM (2004) Assessment of the risk of zinc deficiency in populations and options for its control. Food and Nutrition Bulletin 25, S99-S199.
47. Hotz C, DeHaene J, Woodhouse LR, Villalpando S, Rivera JA & King JC (2005) Zinc absorption from zinc oxide, zinc sulfate, zinc oxide + EDTA, or sodium-zinc EDTA does not differ when added as fortificants to maize tortillas. Journal of Nutrition 135, 1102-1105.
48. Hotz C & Gibson RS (2001) Assessment of home-based processing methods to reduce phytate content and phytate/zinc molar ratios of white maize (Zea mays). Journal of Agricultural and Food Chemistry 49, 692-698.
49. Huddle JM, Gibson RS & Cullinan TR (1998) Is zinc a limiting nutrient in the diets of rural pregnant Malawian women? British Journal of Nutrition 79, 257-265.
50. Institute of Medicine (2001) Dietary Reference Intakes. Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press.
51. King JC (2001) Effect of reproduction on the bioavailability of calcium, zinc, and selenium. Journal of Nutrition 131, 1355S-1358S.
52. Kohn S, Kohn D & Schiller D (2000) Effect of zinc supplementation on epidermal Langerhans' cells of elderly patients with decubital ulcers. Journal of Dermatology 27, 2558-2563.
53. Lönnerdal B (2000) Dietary factors influencing zinc absorption. Journal of Nutrition 130, 1378S-1383S.
54. Lönnerdal B (2004) Interactions between micronutrients: synergies and antagonism. In Micronutrient Deficiencies during the Weaning Period and the First Years of Life. Nestle Nutrition Workshop Series Pediatric Program, vol. 54, pp. 67-81 [JM Pettifor and S Zlotkin, editors]. Vevey, Switzerland: S. Karger AG.
55. Lönnerdal B, Sandberg A-S, Sandström B & Kunz C (1989) Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats. Journal of Nutrition 119, 211-214.
56. Lopez de Romaña D, Brown K & Guinard J-X (2002) Sensory trials to assess the acceptability of zinc fortificants added to iron-fortified wheat products. Journal of Food Science 67, 461-465.
57. Lopez de Romaña D, Lönnerdal B & Brown K (2003) Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. American Journal of Clinical Nutrition 78, 279-283.
58. Mahalanabis D, Chowdhury A, Jana S, Bhattacharya MK, Chakrabarti MK, Waned MA & Khaled MA (2002) Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomized controlled trial. American Journal of Clinical Nutrition 76, 604-607.
59. Mahalanabis D, Madhurima L, Paul D, Gupta A, Wahed MA & Khaled MA (2004) Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. American Journal of Clinical Nutrition 79, 430-436.
60. Makola D, Ash DM, Tatala SR, Latham MC, Ndossi G & Mehansho H (2003) A micronutrient-fortified beverage prevents iron deficiency, reduces anemia and improves the hemoglobin concentration of pregnant Tanzanian women. Journal of Nutrition 133, 1339-1346.
61. Manary MJ, Hotz C, Krebs NF, Gibson RS, Westcott JE, Arnold T, Broadhead RL & Hambidge KM (2000) Dietary phytate reduction improves zinc absorption in Malawian children recovering from tuberculosis but not in well children. Journal of Nutrition 130, 2959-2964.
62. Manary MJ, Hotz C, Krebs NF, Gibson RS, Westcott JE, Broadhead RL & Hambidge KM (2002) Zinc homeostasis in Malawian children consuming a high-phytate, maize-based diet. American Journal of Clinical Nutrition 75, 1057-1061.
63. Meeks Gardner JM, Powell CA, Baker-Henningham H, Walker SP, Cole TJ & Grantham-McGregor SM (2005) Zinc supplementation and psychosocial stimulation: effects on the development of undernourished Jamaican children. American Journal of Clinical Nutrition 82, 399-405.
64. Menzies IS, Zuckerman MJ, Nukajam WS, Somasundaram SG, Murphy B, Jenkins AP, Crane RS & Gregory GG (1999) Geography of intestinal permeability and absorption. Gut 44, 483-489.
65. Merialdi M, Caulfield LE, Zavaleta N, Figueroa A & DiPietro JA (1998) Adding Zn to prenatal iron and folates tablets improves fetal neurobehavioral development. American Journal of Obsterics and Gynecology 180, 483-490.
66. Merialdi M, Caulfield LE, Zavaleta N, Figueroa A, Dominici F & DiPietro JA (2004) Randomized controlled trial of prenatal zinc supplementation and the development of fetal heart rate. American Journal of Obsterics and Gynecology 190, 1106-1112.
67. Muller O, Becher H, van Zweeden AB, Ye Y, Diallo DA, Konate AT, Gbangou A, Kouyate B & Garenne M (2001) Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo-controlled trial. British Medical Journal 322, 1567.
68. Nestel P, Briend A, de Benoist B, Decker E, Ferguson E, Fontaine O, Micardi A & Nalubola R (2003) Complementary food supplements to achieve micronutrient adequacy for infants and young children. Journal of Pediatric Gastroenterology and Nutrition 36, 316-328.
69. Oberleas D & Harland BF (1981) Phytate content of foods: effect on dietary zinc bioavailability. Journal of the American Dietetic Association 79, 433-436.
70. Osendarp SJ, van Raaij JM, Arifeen SE, Wahed M, Baqui AH & Fuchs GJ (2000) A randomized, placebo-controlled trial of the effect of zinc supplementation during pregnancy on pregnancy outcome in Bangladeshi urban poor. American Journal of Clinical Nutrition 71, 114-119.
71. Osendarp SJM, van Raaij JMA, Darmstadt GL, Baqui AH, Hautvast JG & Fuchs GJ (2001) Zinc supplementation during pregnancy and effects on growth and morbidity in low birth-weight infants: a randomized placebo controlled trial. Lancet 357, 1080-1095.
72. Osendarp SJM, West CE & Black RE (2003) The need for maternal zinc supplementation in developing countries: an unresolved issue. Journal of Nutrition 133, 817S-827S.
73. Pabon M & Lönnerdal B (1992) Effect of citrate on zinc bioavailability from milk, milk fractions and infant formulas. Nutrition Research 13, 103-111.
74. Perlas L & Gibson RS (2002) Use of soaking to enhance the bioavailability of iron and zinc from rice-based complementary foods used in the Philippines. Journal of the Science of Food and Agriculture 82, 1115-1124.
75. Prasad AS, Miale A, Farid Z, Sandstead HH & Schulert AR (1963) Zinc metabolism in patients with syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism and hypogonadism. Journal of Laboratory and Clinical Medicine 61, 537-549.
76. Raboy V, Below FE & Dickinson DB (1989) Alterations of maize kernel phytic acid levels by recurrent selection for protein and oil. Journal of Heredity 80, 311-315.
77. Robberstad B, Strand T, Black RE & Sommerfeit H (2004) Cost-effectiveness of zinc as adjunct therapy for acute childhood diarrhea in developing countries. Bulletin of the World Health Organization 82, 523-531.
78. Ruz M, Castillo-Duran C, Lara X, Codoceo J, Rebolledo A & Atalah E (1997) A 14-mo zinc-supplementation trial in apparently healthy Chilean preschool children. American Journal of Clinical Nutrition 66, 1406-1413.
79. Sandstead HH, Penland JG, Alcock NW, Dayal HH, Chen XC, Li JS, Zhao F & Yang JJ (1998) Effects of repletion with zinc and other micronutrients on neuropsychologic performance and growth of Chinese children. American Journal of Clinical Nutrition 68, 470S-475S.
80. Sandström B (2001) Micronutrient interactions: effect on absorption and bioavailability. British Journal of Nutrition 85, S181-S185.
81. Sandström B, Almgren A, Kivsto B & Cederblad A (1989) Effect of protein and protein source on zinc absorption in humans. Journal of Nutrition 119, 48-53.
82. Sandström B, Davidsson L, Cederblad A & Lönnerdal B (1985) Oral iron, dietary ligands and zinc absorption. Journal of Nutrition 115, 411-414.
83. Sazawal S, Bentley M, Black RE, Dhingra P, George S & Bhan MK (1996) Effect of zinc supplementation on observed activity in low socioeconomic Indian preschool children. Pediatrics 98, 1132-1137.
84. Sazawal S, Black RE, Menon VP, Dinghra P, Caulfield LE, Dhingra U & Bagati A (2001) Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. Pediatrics 108, 1280-1286.
85. Shankar AH, Genton B, Baisor M, Paino J, Tamja S, Adiguma T et al. (2000) The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea. American Journal of Tropical Medicine and Hygiene 62, 663-669.
86. Smuts CM, Lombard CJ, Benade AJS, Dhansay MA, Berger J, Hop LT, Lopez de Romana G, Untoro J, Karyadi E, Erhardt J & Gross R (2005) Efficacy of a foodlet-based multiple micronutrient supplement for preventing growth faltering, anemia, and micronutrient deficiency of infants: the four country IRIS trial pooled data analysis. Journal of Nutrition 135, 631S-638S.
87. Sturniolo GC, Montino C, Rossetto L, Martin A, D'Inca R, D'Odorico A & Naccarato R (1991) Inhibition of gastric acid secretion reduces zinc absorption in man. Journal of the American College of Nutrition 10, 372-375.
88. Sunanda L, Sumathi S & Venkatasubbaiah V (1995) Relationship between soil zinc, dietary zinc and zinc nutritional status of humans. Plant Foods for Human Nutrition 48, 201-207.
89. Temple L, Gibson RS & Hotz C (2002) Use of soaking and enrichment for improving the content and bioavailability of calcium, iron and zinc in complementary foods and diets of rural Malawian weanlings. Journal of Food Science 67, 1926-1932.
90. Torrejon CS, Castillo-Suran C, Hertrampf ED & Ruz M (2004) Zinc and iron nutrition in Chilean children fed fortified milk provided by the Complementary National Food Program. Nutrition 20, 177-180.
91. Turnlund JR, King JC, Keyes WR, Gong B & Michel MC (1984) A stable isotope study of zinc absorption in young men: effects of phytate and α-cellulose. American Journal of Clinical Nutrition 40, 1071-1077.
92. United Nations (1991) Some options for improving nutrition in the 1990's. SCN News no. 7, Suppl., 16-18.
93. Villalpando S, Garcia-Guerra A, Ramirez-Sliva CI, Mejoa-Rodriguez F, Matute G, Shaman-Levy T & Rivera JA (2003) Iron, zinc and iodine status in Mexican children under 12 years and women 12-49 y of age. A probablistic national survey. Salud Publica de Mexico 45, S520-S529.
94. Walravens PA & Hambidge KM (1976) Growth of infants fed a zinc supplemented formula. American Journal of Clinical Nutrition 29, 1114-1121.
95. Welch RM & Graham RD (2004) Breeding for micronutrients in staple food crops from a human nutrition perspective. Journal of Experimental Botany 55, 353-364.
96. World Health Organization (1996) Trace Elements in Human Nutrition and Health. Geneva: WHO.
97. World Health Organization (1997) WHO Global Database on Child Growth and Malnutrition. Geneva: WHO.
98. World Health Organization (1999) Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers. Geneva: WHO.
99. World Health Organization/UNICEF (2004) Clinical Management of Acute Diarrhoea. Geneva: WHO.
100. Yilmaz A, Ekiz H, Torun B, Göltekin I, Karanlyk S, Bagcy SA & Cakmak I (1997) Effect of different zinc application methods on grain yield, and zinc concentrations in wheat grown on zinc-deficient calcareous soils in Central Anatolia. Journal of Plant Nutrition 20, 461-471.
101. Zinc Against Plasmodium Study Group (2002) Effect of zinc on the treatment of Plasmodium falciparum malaria in children: a randomized controlled trial. American Journal of Clinical Nutrition 76, 805-812.
102. Zlotkin S, Arthur P, Schauer C, Antwi KY, Yeung G & Piekarz A (2003) Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children. Journal of Nutrition 133, 1075-1080.
103. Zlotkin SH & Cherian MG (1988) Hepatic metallothionein as a source of zinc and cysteine during the first year of life. Pediatric Research 24, 326-329.