Effect of inhibition of farnesylation and geranylgeranylation on renal fibrogenesis in vitro

Nephron - Experimental Nephrology

Volumn 102, Issue 1, 2006, Pages

  Masterson, Rosemary ^a,b   Kelynack, Kristen ^a   Hewitson, Tim ^a,b   Becker, Gavin ^a,b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Farnesyltransferase inhibitor; Geranylgeranyltransferase inhibitor; Prenylation; Ras; Renal fibroblast; Rho

Indexed keywords

BMS 191563; COLLAGEN DERIVATIVE; COLLAGEN GEL; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; GERANYLGERANYLTRANSFERASE; GERANYLTRANSFERASE; GGTI 298; MESSENGER RNA; PHALLOIDIN; PROCOLLAGEN ALPHA1; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL KINETICS; CELL PROLIFERATION; COLLAGEN SYNTHESIS; DOSE RESPONSE; DRUG EFFECT; FIBROBLAST; FIBROGENESIS; KIDNEY FIBROSIS; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STAINING; WESTERN BLOTTING;

ALKYL AND ARYL TRANSFERASES; ANIMALS; APOPTOSIS; BENZAMIDES; CELL PROLIFERATION; COLLAGEN; COLLAGEN TYPE I; CYTOSKELETON; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; FIBROBLASTS; FIBROSIS; GUANOSINE TRIPHOSPHATE; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; KINETICS; MICROFILAMENTS; PROTEIN ISOPRENYLATION; RAS PROTEINS; RATS; RNA, MESSENGER; TIME FACTORS;

EID: 32844462174     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000088403     Document Type: Article

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