Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS

Experimental Neurology

Volumn 198, Issue 1, 2006, Pages 145-153

  Chari, Divya M ^a   Gilson, Jennifer M ^a   Franklin, Robin J M ^a   Blakemore, William F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Demyelination; Oligodendrocyte progenitor cells; Oligodendrocytes; Transplantation; X irradiation

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DENSITY; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; NONHUMAN; OLIGODENDROGLIA; PREDICTION; PRIORITY JOURNAL; RADIATION DOSE; RAT; SPINAL CORD DISEASE; STEM CELL; STEM CELL TRANSPLANTATION; X IRRADIATION;

ANIMALS; ANTIGENS; CASPASE 3; CASPASES; CELL COUNT; CENTRAL NERVOUS SYSTEM DISEASES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; IN SITU HYBRIDIZATION; INDOLES; MALE; MYELIN PROTEOLIPID PROTEIN; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; STEM CELL TRANSPLANTATION; STEM CELLS; TIME FACTORS; X-RAYS;

EID: 32644436264     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2005.11.023     Document Type: Article

References (24)

1. S. Atkinson, Y.Q. Li, and C.S. Wong Changes in oligodendrocytes and myelin gene expression after radiation in the rodent spinal cord Int. J. Radiat. Oncol. Biol. Phys. 57 2003 1093 1100
2. S.L. Atkinson, Y.Q. Li, and C.S. Wong Apoptosis and proliferation of oligodendrocyte progenitor cells in the irradiated rodent spinal cord Int. J. Radiat. Oncol. Biol. Phys. 62 2005 535 544
3. D.M. Chari, and W.F. Blakemore Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells Glia 37 2002 307 313
4. B.M. Chow, Y.Q. Li, and C.S. Wong Radiation-induced apoptosis in the adult central nervous system is p53-dependent Cell Death Differ. 7 2000 712 720
5. M.R. Dawson, A. Polito, J.M. Levine, and R. Reynolds NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS Mol. Cell. Neurosci. 24 2003 476 488
6. A.K. Foote, and W.F. Blakemore Inflammation stimulates remyelination in areas of chronic demyelination Brain 128 2005 528 539
7. R.J.M. Franklin, S.A. Bayley, R. Milner, C. Ffrench-Constant, and W.F. Blakemore Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter Glia 13 1995 39 44
8. R.J.M. Franklin, S.A. Bayley, and W.F. Blakemore Transplanted CG4 cells (an oligodendrocyte progenitor cell line) survive, migrate, and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord but not in normal spinal cord Exp. Neurol. 137 1996 263 276
9. G.L. Hinks, D.M. Chari, M.T. O'Leary, C. Zhao, H.S. Keirstead, W.F. Blakemore, and R.J.M. Franklin Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X-irradiated compared to normal CNS Neuropathol. Appl. Neurobiol. 27 2001 59 67
10. P.J. Horner, A.E. Power, G. Kempermann, H.G. Kuhn, T.D. Palmer, J. Winkler, L.J. Thal, and F.H. Gage Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord J. Neurosci. 20 2000 2218 2228
11. W. Jalabi, M. Cerghet, R.P. Skoff, and M.S. Ghandour Detection of oligodendrocytes in tissue sections using PCR synthesis of digoxigenin-labeled probes J. Histochem. Cytochem. 51 2003 913 919
12. Y.Q. Li, Y.P. Guo, V. Jay, P.A. Stewart, and C.S. Wong Time course of radiation-induced apoptosis in the adult rat spinal cord Radiother. Oncol. 39 1996 35 42
13. Y.Q. Li, V. Jay, and C.S. Wong Oligodendrocytes in the adult rat spinal cord undergo radiation-induced apoptosis Cancer Res. 56 1996 5417 5422
14. G. Li, A.J. Crang, J.L. Rundle, and W.F. Blakemore Oligodendrocyte progenitor cells in the adult rat CNS express myelin oligodendrocyte glycoprotein (MOG) Brain Pathol. 12 2002 463 471
15. J.C. Louis, E. Magal, D. Muir, M. Manthorpe, and S. Varon CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type-2 astrocytes J. Neurosci. Res. 31 1992 193 204
16. A. Nishiyama, X.H. Lin, N. Giese, C.H. Heldin, and W.B. Stallcup Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain J. Neurosci. Res. 43 1996 299 314
17. M.T. O'Leary, and W.F. Blakemore Oligodendrocyte precursors survive poorly and do not migrate following transplantation into the normal adult central nervous system J. Neurosci. Res. 48 1997 159 167
18. T.E. Schultheiss, L.E. Kun, K.K. Ang, and L.C. Stephens Radiation response of the central nervous system Int. J. Radiat. Oncol. Biol. Phys. 31 1995 1093 1112
19. J. Shi, A. Marinovich, and B.A. Barres Purification and characterisation of adult oligodendrocyte precursor cells from the rat optic nerve J. Neurosci. 18 1998 4627 4636
20. N. Shinomiya New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis' J. Cell. Mol. Med. 5 2001 240 253
21. G. Wolswijk, and M. Noble Identification of an adult-specific glial progenitor cell Development 105 1989 387 400
22. C.S. Wong, and A.J. Van der Kogel Mechanisms of radiation injury to the central nervous system: Implications for neuroprotection Mol. Interv. 4 2004 273 284
23. R.H. Woodruff, and R.J.M. Franklin The expression of myelin protein mRNAs during remyelination of lysolecithin-induced demyelination Neuropathol. Appl. Neurobiol. 25 1999 226 235
24. P. Ye, R. Bagnell, and A.J. D'Ercole Mouse NG2+ oligodendrocyte precursors express mRNA for proteolipid protein but not its DM-20 variant: a study of laser microdissection-captured NG2+ cells J. Neurosci. 23 2003 4401 4405