Time course of radiation-induced apoptosis in the adult rat spinal cord

Radiotherapy and Oncology

Volumn 39, Issue 1, 1996, Pages 35-42

  Li, Y Q ^a   Guo, Y P ^a   Jay, V ^b   Stewart, P A ^b   Wong, C S ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b NONE

Author keywords

Apoptosis; CNS radiation injury; Irradiation; Rat spinal cord

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RAT; SPINAL CORD;

EID: 0029867088     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-8140(96)01705-7     Document Type: Article

References (27)

1. Arenas, M.J. and Wyllie, A.H. Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32: 223-254, 1991.
2. Barinaga, M. Death gives birth to the nervous system. But how? Science 259: 762-763, 1993.
3. Bursch, W., Kleine, L. and Tenniswood, M. The biochemistry of cell death by apoptosis. Biochem. Cell Biol. 68: 1071-1074, 1990.
4. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J. Cell Biol. 119: 493-501, 1992.
5. Hong, J.H., Chiang, C.S., Campbell, I.L., Sun, J.R., Withers, H.R. and McBride, W.H. Induction of acute phage gene expression by brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 33: 619-626, 1995.
6. Ijiri, K. and Potten, C.S. Response of intestinal cells of differing topographical and hierarchial status to ten cytotoxic drugs and five sources of radiation. Br. J. Cancer 47: 175-185, 1983.
7. Kameyama, Y. and Inouye, M. Irradiation injury to the developing nervous system: mechanisms of neuronal injury. Neurotoxicology 15: 75-80, 1994.
8. Kramer, S. and Lee, K.F. Complications of radiation therapy: the central nervous system. Semin. Roentgenol. 9: 72-83, 1974.
9. Li, Y.Q., Fan, C., O'Connor, P.J., Winton, D. and Potten, C.S. Target cells for the cytotoxic effects of carcinogens in the marine small bowel. Carcinogenesis 13: 361-368, 1992.
10. Ludwin, S.K., Kosek, J.C. and Eng, L.F. The topographical distribution of S-100 and GFA proteins in the adult rat brain: an immunohistochemical study using horse radish peroxidase-labelled antibodies. J. Comp. Neurol. 165: 197-208, 1975.
11. MacManus, J.P., Buchan, A.M., Hill, I.E., Rasquinha, I. and Preston, E. Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neurosci. Lett. 164: 89-92, 1993.
12. Mastaglia, F.L., McDonald, W.I., Watson, J.V. and Vogendran, K. Effects of X-radiation on the spinal cord: an experimental study of the morphological changes in central nerve fibres. Brain 99: 101-122, 1976.
13. Migheli, A., Cavalla, P., Marino, S. and Schiffer, D. A study of apoptosis in normal and pathologic nervous tissue after in situ end-labelling of DNA strand breaks. J. Neuropathol. Exp. Neurol. 53: 606-616, 1994.
14. Myers, R., Rogers, M.A. and Hornsey, S. A reappraisal of the roles of glial and vascular elements in the development of white matter necrosis in irradiated rats spinal cord. Br. J. Cancer 535: 221-223, 1986.
15. Oppenheim, R.W. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14: 453-501, 1991.
16. Pender, M.P., Nguyen, K.B., McCombe, P.A. and Kerr, J.F.R. Apoptosis in the nervous system in experimental allergic encephalomyelitis. J. Neurol. Sci. 104: 81-88, 1991.
17. Potten, C.S. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metastasis Rev. 11: 179-195, 1992.
18. Sheline, G.E., Wara, W.M. and Smith, V. Therapeutic irradiation and brain injury. Int. J. Radiat. Oncol. Biol. Phys. 6: 1215-1228, 1980.
19. Siegal, T. and Pfeffer, M.R. Radiation-induced changes in the profile of spinal cord serotonin, prostaglandin synthesis, and vascular permeability. Int. J. Radiat. Oncol. Biol. Phys. 31: 57-64, 1995.
20. Sloviter, R.S., Dean, E. and Neubort, S. Electron microscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat: apoptosis in the adult central nervous system. J. Comp. Neurol. 330: 337-351, 1993.
21. Stephens, L.C., Schultheiss, T.E., Price, R.E., Ang, K.K. and Peters, L. J. Radiation apoptosis of serous acinar cells of salivary and lacrimal glands. Cancer 67: 1539-1543, 1991.
22. Stewart, P.A., Vinters, H.V. and Wong, C.S. Blood-spinal cord barrier function and morphometry after single doses of X rays in rat spinal cord. Int. J. Radiat. Oncol. Biol. Phys. 32: 703-711, 1995.
23. Van der Kogel, A.J. Radiation-induced damage in the central nervous system: an interpretation of target cells response. Br. J. Cancer 53 (Suppl. 7): 207-217, 1986.
24. Vrdoljak, E., Bill, C.A., Stephens, L.C., Van der Kogel, A.J., Ang K.K. and Tofilon, P.J. Radiation-induced apoptosis of oligodendrocytes in vitro. Int. J. Radiat. Biol. 62: 475-480, 1992.
25. Wanner, R.A., Edwards, M.J. and Wright, R.G. The effect of hyperthermia on the neuro-epithelium of the 21-day guinea-pig foetus: histologic and ultrastructural study. J. Pathol. 118: 235-244, 1976.
26. Wong, C.S., Minkin, S. and Hill, R.P. Linear-quadratic model underestimates sparing effect of small doses per fraction in rat spinal cord. Radiother. Oncol. 23: 176-184, 1992.
27. Wyllie, A.H., Kerr, J.F.R. and Currie, A.R. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68: 251-306, 1980.