Paradoxical effects of elastase inhibitor guamerin on the tissue repair of two different wound models: Sealed cutaneous and exposed tongue wounds

Experimental and Molecular Medicine

Volumn 36, Issue 3, 2004, Pages 259-267

  Lee, Suk Keun ^a   Lee, Sang Shin ^a   Song, In Sun ^a   Kim, Yeon Sook ^a   Park, Young Wook ^a   Joo, Jae Yong ^a   Um, Heung Sik ^a   Kim, Jin Woo ^a   Kim, Kyeong Yeon ^b   Choi, Seung Jin ^b   Jung, Kyung Hwan ^b   Chung, Soo Il ^a  

^a Gangneung Wonju National University   (South Korea)

^b Mogam Biotechnology Research Institute   (South Korea)

Author keywords

Leukocyte elastase; Mice; Recombinant proteins; Serine proteinase inhibitors; Skin; Tongue; Wound healing

Indexed keywords

ELASTASE INHIBITOR; FIBRIN GLUE; GUAMERIN; LEUKOCYTE ELASTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIZATION; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; SKIN; TISSUE REPAIR; TONGUE; WOUND CLOSURE; WOUND HEALING;

ANIMALIA;

EID: 3242764568     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2004.35     Document Type: Article

References (28)

1. Ashcroft GS, Lei K, Jin W, Longenecker G, Kulkarni AB, Greenwell-Wild T, Hale-Donze H, McGrady G, Song XY, Wahl SM. Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med 2000;6:1147-53
2. Bolliger-Stucki B, Baillod P, Mader W, Furlan M. Biochemical properties of the fibrinogen component of a fibrin glue before and after severe dry heat treatment [In Process Citation]. J Biomed Mater Res 2000;53:577-83
3. Cantin AM, Woods DE. Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection. Am J Respir Crit Care Med 1999; 160:1130-5
4. Drugarin D, Onisei D, Koreck A, Negru S, Drugarin M. Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease. Roum Arch Microbiol Immunol 1998 57:295-307
5. Eley BM, Cox SW. A 2-year longitudinal study of elastase in human gingival crevicular fluid and periodontal attachment loss. J Clin Periodontol 1996 23:681-92
6. Gaboriau HP, Belafsky PC, Pahlavan N, Amedee RG. Closure of mucosal defects over exposed mandibular plates using fibrin glue. Arch Facial Plast Surg 1999;1:191-4
7. Hochstrasser K, Albrecht GJ, Schonberger OL, Rasche B, Lempart K. An elastase-specific inhibitor from human bronchial mucus. Isolation and characterization. Hoppe Seylers Z Physiol Chem 1981;362:1369-75
8. Jung HI, Kim SI, Ha KS, Joe CO, Kang KW. Isolation and characterization of guamerin, a new human leukocyte elastase inhibitor from Hirudo nipponia. J Biol Chem 1995; 270:13879-84
9. Kang K, Bae SJ, Kim WM, Lee D-H, Cho U, Lee MH, Lee M-S, Nam S, Kuettner KE, Schwartz DE. Molecular chracteristics of the inhibition of human neutrophil elastase by nonsteroidal antiinflammatory drugs. Exp Mol Med 2000;32: 146-54
10. Kim DR, Hong SJ, Ha KS, Joe CO, Kang KW. A cysteine-rich serine protease inhibitor (Guamerin II) from the non-blood sucking leech Whitmania edentula: biochemical characterization and amino acid sequence analysis. J Enzyme Inhib 1996;10:81-91
11. Kim KY, Lim HK, Lee KJ, Park DH, Kang KW, Chung SI, Jung KH. Production and characterization of recombinant guamerin, an elastase-specific inhibitor, in the methylotrophic yeast Pichia pastoris. Protein Expr Purif. 2000;20:1-9
12. Kjaergard HK, Velada JL, Pulawska T, Ellensen VS, Larsen SS, Hollingsbee DA. Development of a model for measurement of adhesion strength of fibrin sealant to human tissue. Eur Surg Res 1999;31:491-6
13. Lammers AM, van de Kerkhof PC, Schalwijk J, Mier PD. Elastase, a marker for neutrophils in skin infiltrates. Br J Dermatol 1986;115:181-6
14. Lee SK, Chi JG, Jeon YJ, Park SC, Mori M, Chung SI. Expression of transglutaminase C during the prenatal development of human submandibular glands. J Dent Res 1995; 74:1812-6
15. O'Blenes SB, Zaidi SH, Cheah AY, McIntyre B, Kaneda Y, Rabinovitch M. Gene transfer of the serine elastase inhibitor elafin protects against vein graft degeneration. Circulation 2000;102:111289-95
16. Odani S, Ikenaka T. Studies on soybean trypsin inhibitors. IV. Change of the inhibitory activity of Bowman-Birk inhibitor upon replacements of the alpha-chymotrypsin reactive site serine residue by other amino acids. J Biochem (Tokyo) 1978;84:1-9
17. Palcanis KG, Larjava IK, Wells BR, Suggs KA, Landis JR, Chadwick DE, Jeffcoat MK. Elastase as an indicator of periodontal disease progression. J Periodontol. 1992;63:237-42
18. Rees DD, Brain JD, Wohl ME, Humes JL, Mumford RA. Inhibition of neutrophil elastase in CF sputum by L-658,758. J Pharmacol Exp Ther 1997;283:1201-6
19. Seemuller U, Eulitz M, Fritz H, Strobl A. Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis. Hoppe Seylers Z Physiol Chem 1980;361:1841-6
20. Shin H-H, Kim S-G, Lee M-H, Suh J-H, Kwon BS, Choi H-S. Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice. Exp Mol Med 2003;35:358-64
21. Shin YH, Kweon OK, Fang MZ, Kim MY, Kwak HI, Son JW, Kim JH, Bae MO, Kim KY, choi SJ, Jung KH, Cho MH. Effects of guamerin, urinary trypsin inhibitor (UTI), and combined therapy of guamerin and UTI on cerulein-induced acute pancreatitis rat model. Asian Pacific J of Pharmacology 2000;14:21-25
22. Song M, Zaninovic V, Kim D, Gukovsky I, Gukovskaya A, Kang K, Pandol S. Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Pancreas 1999;18:231-9
23. Tonai T, Shiba K, Taketani Y, Ohmoto Y, Murata K, Muraguchi M, Ohsaki H, Takeda E, Nishisho T. A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats. J Neurochem 2001;78:1064-72
24. Tremblay GM, Janelle MF, Bourbonnais Y. Tremblay GM, Janelle MF, Bourbonnais Y, Anti-inflammatory activity of neutrophil elastase inhibitors. Curr Opin Investig Drugs. 2003 May;4(5):556-65
25. Ueno M, Moriyama Y, Toda R, Yotsumoto G, Yamamoto H, Fukumoto Y, Sakasegawa K, Nakamura K, Sakata R. Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model. J Heart Lung Transplant 2001;20:889-96
26. Waugh JM, Li-Hawkins J, Yuksel E, Cifra PN, Amabile PG, Hilfiker PR, Geske RS, Kuo MD, Thomas JW, Dake MD, Woo SL. Therapeutic elastase inhibition by alpha-1-antitrypsin gene transfer limits neointima formation in normal rabbits. J Vasc Interv Radiol 2001;12:1203-9
27. Wright CD, Kennedy JA, Zitnik RJ, Kashem MA. Inhibition of murine neutrophil serine proteinases by human and murine secretory leukocyte protease inhibitor. Biochem Biophys Res Commun 1999;254:614-7
28. Zaidi SHE, You X-M, Ciura S, O'Blenes S, Husain M, Rabinovitch M. Suppressed smooth muscle proliferation and inflammatory cell invasion after arterial injury in elafin-overexpressing mice. J Clin Invest 2000;105:1687-95