Inhibition of neutrophil elastase in CF sputum by L-658,758

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 3, 1997, Pages 1201-1206

  Rees, Dianne D ^a,d   Brain, Joseph D ^a   Wohl, Mary Ellen ^b   Humes, John L ^c   Mumford, Richard A ^c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d CBR Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETOXYMETHYL 2 (2 CARBOXY 1 PYRROLIDINYLCARBONYL) 7ALPHA METHOXY 8 OXO 5 THIA 1 AZABICYCLO[4.2.0]OCT 2 ENE 5,5 DIOXIDE; ALPHA 1 ANTITRYPSIN; BACTERIAL ENZYME; EDETIC ACID; ELASTASE INHIBITOR; ELASTIN; LEUKOCYTE ELASTASE; METHOXYSUCCINYLALANYLALANYLPROLYLVALINE CHLOROMETHYL KETONE; MYELOBLASTIN; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; HUMAN; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; PSEUDOMONAS AERUGINOSA;

ADULT; ANIMALS; CEPHALOSPORINS; CYSTIC FIBROSIS; HUMANS; LEUKOCYTE ELASTASE; MICE; SERINE PROTEINASE INHIBITORS; SPUTUM;

EID: 0031443570     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. AMITANI, R., WILSON, R. , RUTMAN, A. , READ, R. , WARD, C. , BURNETT, D. , STOCKLEY, R. A. AND COLE, P. J.: Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium. Am. J. Respir. Cell Mol. Biol. 4: 26-32, 1991.
2. BANDA, M. J. AND WERB, Z.: Mouse macrophage elastase. Purification and characterization as a metalloproteinase. Biochem. J. 193: 589-605, 1981.
3. BAUMSTARK, J. S., LEE, C. T. AND LUBY, R. J.: Rapid inactivation of alpha1-protease inhibitor (alpha1-antitrypsin) by elastase. Biochim. Biophys. Acta 482: 400-411, 1977.
4. BERGER, M.: Inflammation in the lung in cystic fibrosis. A vicious cycle that does more harm than good? [Review]. Clin. Rev. Allergy 9: 119-142, 1991.
5. BIETH, J. G.: Elastases: Catalytic and biological properties. In Regulation of Matrix Accumulation, ed. by R. P. Mecham, pp. 217-320, Academic Press, New York, 1986.
6. BIRRER, P., MCELVANEY, N. G., RUDEBERG, A., SOMMER, C. W., LIECHTI-GALLATI, S., KRAEMER, R., HUBBARD, R. AND CRYSTAL, R. G.: Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am. J. Respir. Crit. Care Med. 150: 207-213, 1994.
7. BONNEY, R. J., ASHE, B., MAYCOCK, A., DELLEA, P., HAND, K., OSINGA, D., FLETCHER, D., MUMFORD, R., DAVIES, P., FRANKENFIELD, D., NOLAN, T., SCHAEFFER, L., HAGMANN, W., FINKE, P., SHAH, S., DORN, C. AND DOHERTY, J.: Pharmacological profile of the substituted beta-lactam L-659,286: A member of a new class of human PMN elastase inhibitors. J. Cell. Biochem. 39: 47-53, 1989.
8. BRUCE, M. C., PONCZ, L., KLINGER, J. D., STERN, R. C., TOMASHEFSKI, J., JR. AND DEARBORN, D. G.: Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis. Am. Rev. Respir. Dis. 132: 529-535, 1985.
9. CANTIN, A., BILODEAU, G. AND BEGIN, R.: Granulocyte elastase-mediated proteolysis of alpha 1-antitrypsin in cystic fibrosis bronchopulmonary secretions. Pediatr. Pulmonol. 7: 12-17, 1989.
10. CHAPMAN, H., JR. AND STONE, O. L.: Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors. J. Clin. Invest. 74: 1693-1700, 1984.
11. CHRISTENSEN, T. G., BREUER, R., HORNSTRA, L. J., LUCEY, E. C., STONE, P. J. AND SNIDER, G. L.: An ultrastructural study of the response of hamster bronchial epithelium to human neutrophil elastase. Exp. Lung Res. 13: 279-297, 1987.
12. DAVIES, P., ASHE, B. M., BONNEY, R. J., DORN, C., FINKE, P., FLETCHER, D., HANLON, W. A., HUMES, J. L., MAYCOCK, A., MUMFORD, R. A., NAVIA, M., OPAS, E. E., PACHOLOK, S., SHAH, S., ZIMMERMAN, M. AND DOHERTY, J.B.: The discovery and biologic properties of cephalosporin-based inhibitors of PMN elastase. [Review]. Ann. New York Acad. Sci. 624: 219-229, 1991.
13. DAVIS, P. A., DRUMM, M. AND KONSTAN, M.: Cystic fibrosis. Am. J. Respir. Crit. Care Med. 154: 1229-1256, 1996.
14. DOHERTY, J. B., ASHE, B. M., ARGENBRIGHT, L. W., BARKER, P. L., BONNEY, R. J., CHANDLER, G. O., DAHLGREN, M. E., DORN, C. P., JR, FINKE, FIRESTONE, R. A., FLETCHER, D., HAGMANN, W. K., MUMFORD, R., O'GRADY, L., MAYCOCK, A. L., PISANO, J. M., SHAH, S. K., THOMPSON, K. R. AND ZIMMERMAN, M.: Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase. Nature (Lond.) 322: 192-194, 1986.
15. FICK, R., JR., NAEGEL, G. P., SQUIER, S. U., WOOD, R. E., GEE, J. B. AND REYNOLDS, H. Y.: Proteins of the cystic fibrosis respiratory tract. Fragmented immunoglobulin G opsonic antibody causing defective opsonophagocytosis. J. Clin. Invest. 74: 236-248, 1984.
16. FLETCHER, D. S., OSINGA, D. G., BONNEY, R. J., KEENAN, K., FINKE, P., DOHERTY, J. B. AND DAVIES, P.: The role of polymorphonuclear leukocyte elastase in immune complex-mediated tissue injury in the lung. Am. Rev. Respir. Dis. 141: A11, 1990a.
17. FLETCHER, D. S., OSINGA, D. G., HAND, K. M., DELLEA, P. S., ASHE, B. M., MUMFORD, R. A., DAVIES, P., HAGMANN, W., FINKE, P. E., DOHERTY, J. B. AND BONNEY, R. J. : A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster. Am. Rev. Respir. Dis. 141: 672-677, 1990b.
18. GORDON, S., WERB, Z. AND COHN, Z. A.: Methods for detection of macrophage secretory enzymes. In In Vitro Methods in Cell-Mediated and Tumor Immunity, ed. by E. B. Bloom and J. R. David, pp. 349-351, Academic Press, New York, 1976.
19. HAMDAOUI, A., WUND-BISSERET, F. AND BIETH, J. G.: Fast solubilization of human lung elastin by Pseudomonas aeruginosa elastase. Am. Rev. Respir. Dis. 135: 860-863, 1987.
20. JACKSON, A. H., HILL, S. L., AFFORD, S. C. AND STOCKLEY, R. A.: Sputum sol-phase proteins and elastase activity in patients with cystic fibrosis. Eur. J. Respir. Dis. 65: 114-124, 1984.
21. JOHNSON, D. A., CARTER-HAMM, B. AND DRALLE, W. M.: Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase. Am. Rev. Respir. Dis. 126: 1070-1073, 1982.
22. KAO, R. C., WEHNER, N. G., SKUBITZ, K. M., GRAY, B. H. AND HOIDAL, J. R.: Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. J. Clin. Invest. 82: 1963-1973, 1988.
23. KHAN, T. Z., WAGENER, J. S., BOST, T., MARTINEZ, J., ACCURSO, F. J. AND RICHES, D.: Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 151: 1075-1082, 1995.
24. KLINGER, J. D., TANDLER, B., LIEDTKE, C. M. AND BOAT, T. F.: Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium. J. Clin. Invest. 74: 1669-1678, 1984.
25. KNIGHT, W. B., GREEN, B. G., CHABIN, R. M., GALE, P., MAYCOCK, A. L., WESTON, H., KUO, D. W., WESTLER, W. M., DORN, C. P., FINKE, P. E., HAGMANN, W. K., HALE, J. J., LIESCH, J., MACCOSS, M., NAVIA, M. A., SHAH, S. K., UNDERWOOD, D. AND DOHERTY, J. B.: Specificity, stability, and potency of monocyclic beta-lactam inhibitors of human leukocyte elastase. Biochem. 31: 8160-8170, 1992a.
26. KNIGHT, W. B., MAYCOCK, A. L., GREEN, B. G., ASHE, B. M., GALE, P., WESTON, H., FINKE, P. E., HAGMANN, W. K., SHAH, S. K. AND DOHERTY, J. B.: Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives. Biochemistry 31: 4980-4986, 1992b.
27. LLEWELLYN-JONES, C. G., LOMAS, D. A. AND STOCKLEY, R. A.: Potential role of recombinant secretory leucoprotease inhibitor in the prevention of neutrophil mediated matrix degradation. Thorax 49: 567-572, 1994.
28. LUCEY, E. C., STONE, P. J., CHRISTENSEN, T. G., BREUER, R. AND SNIDER, G. L.: An 18-month study of the effects on hamster lungs of intratracheally administered human neutrophil elastase. Exp. Lung Res. 14: 671-686, 1988.
29. MCELVANEY, N. G., NAKAMURA, H., BIRRER, P., HEBERT, C. A., WONG, W. L., ALPHONSO, M., BAKER, J. B., CATALANO, M. A. AND CRYSTAL, R. G.: Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J. Clin. Invest. 90: 1296-1301, 1992.
30. MORIHARA, K., TSUZUKI, H. AND ODA, K.: Protease and elastase of Pseudomonas aeruginosa: Inactivation of human plasma alpha 1-proteinase inhibitor. Infect. Immun. 24: 188-193, 1979.
31. MORIHARA, K., TSUZUKI, H., OKA, T., INOUIE, H. AND EBATA, M.: Pseudomonas aeruginosa elastase: Isolation, crystallization and preliminary characterization. J. Biol. Chem. 240: 3295-3304, 1965.
32. NAKAMURA, H., YOSHIMURA, K., MCELVANEY, N. G. AND CRYSTAL, R. G.: Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J. Clin. Invest. 89: 1478-1484, 1992.
33. O'CONNOR, C. M., GAFFNEY, K., KEANE, J., SOUTHEY, A., BYRNE, N., O'MAHONEY, S. AND FITZGERALD, M. X.: Alpha 1-proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis. Am. Rev. Respir. Dis. 148: 1665-1670, 1993.
34. PLOTKOWSKI, M. C., BECK, G., TOURNIER, J. M., BERNARDO-FILHO, M., MARQUES, E. A. AND PUCHELLE, E.: Adherence of Pseudomonas aeruginosa to respiratory epithelium and the effect of leucocyte elastase. J. Med. Microbiol. 30: 285-293, 1989.
35. RAO, N. V., MARSHALL, B. C., GRAY, B. H. AND HOIDAL, J. R.: Interaction of secretory leukocyte protease inhibitor with proteinase-3. Am. J. Respir. Cell Mol. Biol. 8: 612-616, 1993.
36. RAO, N. V., WEHNER, N. G., MARSHALL, B. C., GRAY, W. R., GRAY, B. H. AND HOIDAL, J. R.: Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase: Structural and functional properties. J. Biol. Chem. 1991.
37. REES, D. D. AND BRAIN, J. D.: Effects of cystic fibrosis airway secretions on rat lung: Role of neutrophil elastase. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L195-L202, 1995.
38. RICHMANEISENSTAT, J. B., JORENS, P. G., HEBERT, C. A., UEKI, I. AND NADEL, J. A.: Interleukin-8: An important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am. J. Physiol. 264: L413-418, 1993.
39. SALVESON, G. AND TRAVIS, J.: Properties of naturally occurring elastase inhibitors. In Elastin and Elastases, ed. by L. Robert and W. Hornebeck, pp. 95-108, CRC Press, Inc., Boca Raton, FL, 1989.
40. SHAPIRO, S. D.: Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease. [Review]. Am. J. Respir. Crit. Care Med. 150: S160-164, 1994.
41. SHAPIRO, S. D., KOBAYASHI, D. K. AND LEY, T. J.: Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J. Bio. Chem. 268: 23824-23829, 1993.
42. SOMERVILLE, M., RICHARDSON, P. S., RUTMAN, A., WILSON, R. AND COLE, P. J.: Stimulation of secretion into human and feline airways by Pseudomonas aeruginosa proteases. J. App. Physiol. 70: 2259-2267, 1991.
43. STONE, P. J., LUCEY, E. C., VIRCA, G. D., CHRISTENSEN, T. G., BREUER, R. AND SNIDER, G. L.: Alpha 1-protease inhibitor moderates human neutrophil elastase-induced emphysema and secretory cell metaplasia in hamsters. Eur. Respir. J. 3: 673-678, 1990.
44. SUTER, S. AND CHEVALLIER, L: Proteolytic inactivation of alpha 1-proteinase inhibitor in infected bronchial secretions from patients with cystic fibrosis. E. Respir. J. 4: 40-49, 1991.
45. SUTER, S., SCHAAD, U. B., ROUX, L., NYDEGGER, U. E. AND WALDVOGEL, F. A.: Granulocyte neutral proteases and Pseudomonas elastase as possible causes of airway damage in patients with cystic fibrosis. J. Inf. Dis. 149: 523-531 1984.
46. TOSI, M. F., ZAKEM, H. AND BERGER, M.: Neutrophil elastase cleaves C3bi on opsonized Pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J. Clin. Invest 86: 300-308 1990.
47. TOURNIER, J. M., JAQUOT, J., PUCHELLE, E. AND BIETH, J. G.: Evidence that Pseudomonas aeruginosa, elastase does not inactivate the bronchial inhibitor in the presence of leukocyte elastase. Am. Rev. Respir. Dis. 132: 524-528, 1985.
48. WILLIAMS, J. C., LUCAS, B. J., KNEE, C., RENZETTI, M. AND DONAHUE, J.: Acute lung injury induced by Pseudomonas aeruginosa elastase in hamsters. Exp. Lung Res. 18: 155-171, 1992.
49. WOODS, D. E., BASS, J. A., JOHANSON, W., JR. AND STRAUS, D. C.: Role of adherence in the pathogenesis of Pseudomonas aeruginosa lung infection in cystic fibrosis patients. Inf. Imm. 30: 694-699, 1980.
50. WRETLIND, B. AND PAVLOVSKIS, O. R.: Pseudomonas aeruginosa elastase and its role in Pseudomonas infections. [Review]. Rev. Infect. Dis. 5: S998-1004 1983.