Aerosolized Prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection

American Journal of Respiratory and Critical Care Medicine

Volumn 160, Issue 4, 1999, Pages 1130-1135

  Cantin, André M ^a,b,c   Woods, Donald E ^a,b  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; LEUKOCYTE ELASTASE;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BACTERIUM COLONY; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG ACTIVITY; DRUG INHIBITION; ENZYME ACTIVITY; INFECTION CONTROL; LUNG INFECTION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RAT;

EID: 0032882814     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.160.4.9807166     Document Type: Article

References (29)

1. Riordan, J. R., J. M. Rommens, B.-S. Kerem, N. Alon, U. Rozmahel, Z. Grzelczak, J. Zielenski, S. Lok, N. Plavsic, J.-L. Chou, M. L. Drumm, M. C. Iannuzzi, F. S. Collins, and L.-C. Tsui. 1989. Identification of the cystic fibrosis gene: cloning and characterization of complementary cDNA. Science 245:1066-1073.
2. Engelhardt, J. F., J. R. Yankaskas, S. A. Ernst, Y. Yang, C. R. Marino, R. C. Boucher, J. A. Cohn, and J. M. Wilson. 1992. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat. Genet. 2:240-248.
3. Inglis, S. K., M. R. Corboz, A. E. Taylor, and S. T. Ballard. 1997. Effect of anion transport inhibition on mucus secretion by airway submucosal glands. Am. J. Physiol. 272:L372-L377.
4. Smith, J. J., S. M. Travis, E. P. Greenberg, and M. J. Welsh. 1996. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85:229-236.
5. Goldman, M. J., G. M. Anderson, E. D. Stolzenberg, U. P. Kari, M. Zasloff, and J. M. Wilson. 1997, Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553-560.
6. DiMango E., H. J. Zar, R. Bryan, and A. Prince. 1995. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J. Clin. Invest. 96:2204-2210.
7. Khan, T. Z., J. S. Wagener, T. Bust, J. Martinez, F. J. Accurso, and D. W. H. Riches. 1995. Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 151:1075-1082.
8. Birrer, P., N. G. McElvaney, A. Rüdeberg, C. Wirz Sommer, S. Liechti-Gallati, R. Kraemer, R. Hubbard, and R. G. Crystal. 1994. Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am. J. Respir. Crit. Care Med. 150:207-213.
9. Konstan, M. W., K. A. Hilliard, T. M. Norvell, and M. Berger. 1994. Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am. J. Respir. Crit. Care Med. 150:448-454.
10. Schuster, A., I. Ueki, and J. A. Nadel. 1992. Neutrophil elastastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200,355. Am, J. Physiol. 262:L86-L91.
11. Turino, G. M., R. V. Laureno, and G. H. McCracken. 1969. Role of connective tissue in large pulmonary airways. J. Appl. Physiol. 25:645-653.
12. Nakamura, H., K. Yoshimura, N. G. McElvaney, and R. G. Crystal. 1992. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line J. Clin. Invest. 89:1478-1484.
13. Richman-Eisenstat, J. B. Y., P. G. Jorens, C. A. Hébert, I. Ueki, and J. A. Nadel. 1993. Interluekin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am. J. Physiol. 264:L413-L418.
14. Berger, M., R. V. Sorenson, M. F. Tosi, D. G. Dearborn, and G. Döring. 1989, Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis, J. Clin, invest. 84:1302-1313.
15. Tosi, M. F., H. Zakem, and M. Berger. 1990. Neutrophil clastase cleaves C3bi on opsonized Pseudomonas as well as CRI on neutrophils to create a functionally important opsonin receptor mismatch. J. Clin. Invest. 86:300-308.
16. Suter, S., U. B. Schaad, H. Tegner, K. Ohlsson, D. Desgrandchamps, and F. A. Waldvogel. 1986. Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effect of antimicrobial treatment against Pseudomonas aeruginosa. J. Infect. Dis. 153:902-909.
17. Goldstein, W., and G. Döring. 1986. Lysosomal enzymes from polymorphonuclear leukocytes and protease inhibitors in patients with cystic fibrosis. Am. Rev. Respir. Dis. 134:49-56.
18. 1-antitrypsin in cystic fibrosis bronchopulmonary secretions. Pediatr. Pulmonol. 7:12-17.
19. McElvaney, N. G., R. C. Hubbard, P. Birrer, M. S. Chernick, D. B. Caplan, M. M. Frank, and R. G. Crystal. 1991. Aerosol administration of αl-antitrypsin to suppress the burden of active neutrophil elastase on the respiratory epithelial surface in cystic fibrosis. Lancet 337:392-394.
20. McElvaney, N. G., H. Nakamura, P. Birrer, C. A. Hébert, W. L. Wong, M. Alphonse, J. B. Baker, M. A. Catalano, and R. G. Crystal. 1992. Modulation of airway inflammation in cystic fibrosis: In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J. Clin. Invest. 90:1296-1301.
21. Belaaouaj, A. K. McCarthy, M. Baumann, Z. Gao, T. J. Ley, S. N. Abraham, and S. D. Shapiro. 1998. Mice lacking neutrophil clastase reveal impaired host defense against gram negative bacterial sepsis. Nat. Med. 5:613-618.
22. Virca, G. D., G. Metz, and H. P. Schnebli. 1984. Similarities between human and rat leukocyte clastase and cathepsin G. Eur. J. Biochem. 144:1-9.
23. Cash, H. A., D. E. Woods, B. McCullough, W. G. Johanson, Jr., and J. A. Bass. 1979. A rat model of chronic respiratory infection with Pseudomonas aeruginosa. Am. Rev. Respir. Dis 119:453-459.
24. Sokol, P. A., and D. E. Woods. 1984. Relationship of iron and and extracellular virulence factors to Pseudomonas aeruginosa lung infections, J. Med Microbiol. 18:125-133.
25. Snedecor, G. W., and W. G. Cochrane. 1980. Statistical Methods, 7th ed. Iowa State University Press, Ames, IA.
26. Woods, D. E., S. J. Cryz, R. L. Friedman, and B. H. Iglewski. 1982. Contribution of toxin A and clastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats. Infect. Immun. 36:1223-1228.
27. Woods, D. E., and L., E. Bryan. 1985. Studies on the ability of alginate to act as a protective immunogen against Pseudomonas aeruginosa infection in animals. J. Infect. Dis. 151:581-588.
28. Woods, D. E., P. A. Sokol, L. E. Bryan, D. G. Storey, S. J. Mattingly, H. J. Vogel, and H. Ceri. 1991. In vivo regulation of virulence, in Pseudomonas aeruginosa associated with genetic rearrangement. J. Infect. Dis. 163:143-149.
29. Grimwood, K., M. To, H. R. Rabin, and D. E. Woods. 1989. Subinhibitory antibiotics reduce Pseudomonas aeruginosa tissue injury in the rat lung model. J. Antimicrob. Chemother. 24:937-945.