Antibody class switching: Uncoupling S region accessibility from transcription

Trends in Genetics

Volumn 20, Issue 8, 2004, Pages 337-340

  Kaminski, Denise A ^a   Stavnezer, Janet ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH FACTOR; CYTIDINE DEAMINASE; DNA GLYCOSYLTRANSFERASE; HISTONE; IMMUNOGLOBULIN G1; INTERLEUKIN 4; RNA; RNA POLYMERASE II; SINGLE STRANDED DNA;

ACETYLATION; CHROMATIN; EXON; GENE EXPRESSION; GENE LOCUS; GENE SWITCHING; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENOME; HUMAN; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SOMATIC HYPERMUTATION;

EID: 3242740421     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2004.06.008     Document Type: Short Survey

References (34)

1. Wang C.L., Wabl M. DNA acrobats of the Ig class switch. J. Immunol. 172:2004;5815-5821
2. Muramatsu M., et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:2000;553-563
3. Revy P., et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell. 102:2000;565-575
4. Petersen-Mahrt S.K., et al. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 418:2002;99-104
5. Di Noia, J. and Neuberger, M.S. (2002) Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419, 43-48.
6. Martin A., et al. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature. 415:2002;802-806
7. Storb U., Stavnezer J. Immunoglobulin genes: generating diversity with AID and UNG. Curr. Biol. 12:2002;R725-R727
8. Stavnezer J., Bradley S.P. Does activation-induced deaminase initiate antibody diversification by DNA deamination? Trends Genet. 18:2002;541-594
9. Nambu Y., et al. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science. 302:2003;2137-2140
10. Stavnezer J. Molecular processes that regulate class switching. Curr. Top. Microbiol. Immunol. 245:2000;127-168
11. Manis J.P., et al. Mechanism and control of class-switch recombination. Trends Immunol. 23:2002;31-39
12. Hein K., et al. Processing of switch transcripts is required for targeting of antibody class switch recombination. J. Exp. Med. 188:1998;2369-2374
13. Bottaro A., et al. S region transcription (per se) promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 13:1994;665-674
14. Jenuwein T., Allis C.D. Translating the histone code. Science. 293:2001;1074-1080
15. Chaudhuri J., et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 422:2003;726-730
16. Dickerson S.K., et al. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197:2003;1291-1296
17. Bransteitter R., et al. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. U. S. A. 100:2003;4102-4107
18. Sohail A., et al. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31:2003;2990-2994
19. Ramiro A.R., et al. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4:2003;452-456
20. Korzheva N., et al. A structural model of transcription elongation. Science. 289:2000;619-625
21. Rada C., et al. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12:2002;1748-1755
22. Imai K., et al. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat. Immunol. 4:2003;1023-1028
23. Kavli B., et al. hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup. J. Biol. Chem. 277:2002;39926-39936
24. Yu, K. et al. (2003) R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 4, 442-451.
25. Reaban M.E., Griffin J.A. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature. 348:1990;342-344
26. Daniels G.A., Lieber M.R. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res. 23:1995;5006-5011
27. Shinkura R., et al. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:2003;435-441
28. Longacre A., Storb U. A novel cytidine deaminase affects antibody diversity. Cell. 102:2000;541-544
29. Yoshikawa K., et al. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science. 296:2002;2033-2036
30. Okazaki I.M., et al. Constitutive expression of AID leads to tumorigenesis. J. Exp. Med. 197:2003;1173-1181
31. Michael N., et al. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity. 19:2003;235-242
32. Ito S., et al. Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc. Natl. Acad. Sci. U. S. A. 101:2004;1975-1980
33. McBride K.M., et al. Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J. Exp. Med. 199:2004;1235-1244
34. Brar, S. et al. Activation-induced cytidine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks. J. Biol. Chem. (in press).