Altered substrate specificity in flavocytochrome b2: Structural insights into the mechanism of L-lactate dehydrogenation

Biochemistry

Volumn 43, Issue 29, 2004, Pages 9519-9526

  Mowat, Christopher G ^a   Wehenkel, Annemarie ^a   Green, Amanda J ^a   Walkinshaw, Malcolm D ^a   Reid, Graeme A ^a   Chapman, Stephen K ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; DEHYDROGENATION; ENZYME KINETICS; ENZYMES; OXIDATION;

FLAVOCYTOCHROMES; HYDRIDE TRANSFER; MUTANT ENZYMES;

BIOCHEMISTRY;

(S) 2 HYDROXY ACID OXIDASE; ALANINE; CYTOCHROME C OXIDASE; FLAVINE MONONUCLEOTIDE; FLAVINE MONONUCLEOTIDE SULFITE; FLAVOPROTEIN; GLYCINE; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE (CYTOCHROME); MANDELIC ACID; PHENYLGLYOXYLIC ACID; SULFITE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEHYDROGENATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; OXIDATION; PRIORITY JOURNAL; PROTEIN FAMILY; REDUCTION; SACCHAROMYCES CEREVISIAE; STEREOCHEMISTRY; WILD TYPE;

AMINO ACID SEQUENCE; HYDROGEN; L-LACTATE DEHYDROGENASE (CYTOCHROME); LACTIC ACID; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 3242733821     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049263m     Document Type: Article

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