Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - Role of KARAP/DAP12-dependent and -independent pathways

European Journal of Immunology

Volumn 34, Issue 6, 2004, Pages 1646-1653

  Öberg, Linda ^a   Johansson, Sofia ^a   Michaëlsson, Jakob ^a,c   Tomasello, Elena ^b   Vivier, Eric ^b   Kärre, Klas ^a   Höglund, Petter ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CFSE; In vivo; MHC class I; NK cells

Indexed keywords

ADAPTOR PROTEIN; BETA 2 MICROGLOBULIN; CONCANAVALIN A; INTERFERON; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; 6 CARBOXYFLUORESCEIN; 6-CARBOXYFLUORESCEIN; FLUORESCEIN DERIVATIVE; H2 ANTIGEN; IMMUNOGLOBULIN RECEPTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TYROBP PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ALLELE; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DONOR; HEMATOPOIETIC CELL; IN VIVO STUDY; LYMPHOCYTE; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; RECIPIENT; SIGNAL TRANSDUCTION; TUMOR CELL; ANIMAL; B LYMPHOCYTE; BAGG ALBINO MOUSE; BONE MARROW CELL; C57BL MOUSE; CHEMISTRY; CYTOTOXICITY; FLOW CYTOMETRY; IMMUNOLOGY; MOUSE MUTANT; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; B-LYMPHOCYTES; BETA 2-MICROGLOBULIN; BONE MARROW CELLS; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; FLUORESCEINS; H-2 ANTIGENS; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES;

EID: 3242731492     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200424913     Document Type: Article

References (36)

1. Ljunggren, H. G. and Kärre, K., In search of the 'missing self': MHC molecules and NK cell recognition. Immunol. Today 1990. 11: 237-244.
2. Long, E. O., Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 1999. 17: 875-904.
3. Ravetch, J. V. and Lanier, L. L., Immune inhibitory receptors. Science 2000. 290: 84-89.
4. Raulet, D. H., Vance, R. E. and McMahon, C. W., Regulation of the natural killer cell receptor repertoire. Annu. Rev. Immunol. 2001. 19: 291-330.
5. Anderson, S. K., Ortaldo, J. R. and McVicar, D. W., The ever-expanding Ly49 gene family: repertoire and signaling. Immunol. Rev. 2001. 181: 79-89.
6. George, T. C., Ortaldo, J. R., Lemieux, S., Kumar, V. and Bennett, M., Tolerance and alloreactivity of the Ly49D subset of murine NK cells. J. Immunol. 1999. 163: 1859-1867.
7. Mason, L. H., Andersson, S. K., Yokoyama, W. M., Smith, H. R, Winkler-Pickett, R. and Ortaldo, J., The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 1996. 184: 2119-2128.
8. Mason, L. H., Willette-Brown, J., Andersson, S. K., Gosselin, P., Shores, E. W., Love, P. E., Ortaldo, J. R. and McVicar, D. W., Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction. J. Immunol. 1998. 160: 4148-4152.
9. Smith, K. M., Wu, J., Bakker, A. B., Phillips, J. H. and Lanier, L. L., Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 1998. 161: 7-10.
10. Ryan, J. C., Naper, C., Hayashi, S. and Daws, M. R., Physiologic functions of activating natural killer (NK) complex-encoded receptors on NK cells. Immunol. Rev. 2001. 181: 126-137.
11. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M. C., Biassoni, R. and Moretta, L., Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 2001. 19: 197-223.
12. Long, E. O., Versatile signaling through NKG2D. Nat. Immunol. 2002. 3: 1119-1120.
13. Bottino, C., Falco, M., Parolini, S., Marcenaro, E., Augugliaro, R., Sivori, S., Landi, E., Biassoni, R., Notarangelo, L. D., Moretta, L. and Moretta, A., NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J. Exp. Med. 2001. 194: 235-246.
14. Sivori, S., Falco, M., Marcenaro, E., Parolini, S., Biassoni, R., Bottino, C., Moretta, L. and Moretta, A., Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc. Natl. Acad. Sci. USA 2002. 99: 4526-4531.
15. Riccardi, C., Santoni, A., Barlozzari, T., Puccetti, P. and Herberman, R. B., In vivo natural reactivity of mice against tumor cells. Int. J. Cancer 1980. 25: 475-486.
16. Lanier, L. L., On guard - activating NK cell receptors. Nat. Immunol. 2001. 2: 23-27.
17. Ruggeri, L., Capanni, M., Urbani, E., Perruccion, K., Schlomcik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., Martelli, M. F. and Velardi, A., Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002. 295: 2097-2100.
18. Yu, Y. Y., Kumar, V. and Bennett, M., Murine natural killer cells and marrow graft rejection. Annu. Rev. Immunol. 1992. 10: 189-213.
19. Höglund, P., Glas, R., Öhlén, C., Ljunggren, H.-G. and Kärre, K., Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target. J. Exp. Med. 1991. 174: 327-334.
20. Ljunggren, H.-G. and Kärre, K., Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism. J. Exp. Med. 1985. 162: 1745-1759.
21. Bix, M., Liao, N. S., Zijlstra, M., Loring, J., Jaenisch, R. and Raulet, D. H., Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice. Nature 1991. 349: 329-331.
22. Rolstad, B. and Ford, W. L., The rapid elimination of allogeneic lymphocytes: relationship to established mechanisms of immunity and to lymphocyte traffic. Immunol. Rev. 1983. 73: 87-113.
23. Rolstad, B., Fossum, S., Bazin, H., Kimber, I., Marshall, J., Sparshott, S. M. and Ford W. L., The rapid rejection of allogeneic lymphocytes by a non-adaptive, cell-mediated mechanism (NK activity). Immunology 1985. 54: 127-138.
24. Barchet, W., Oehen, S., Kleneman, P., Wodarz, D., Bocharov, G., Lloyd, A. L., Nowak, M. A., Hengartner, H., Zinkernagel, R. M. and Ehl, S., Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo. Eur. J. Immunol. 2000. 30: 1356-1363.
25. Hanke, T., Takizava, H., McMahon, C. W., Busch, D. H., Pamer, E. G., Miller, J. D., Altman, J. D., Liu, Y., Cado, D., Lemmonier, F. A., Bjorkmann, P. J. and Raulet, D. H., Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 1999. 11: 67-77.
26. Michaëlsson, J., Achour, A., Salcedo, M., Kåse-Sjöström, A., Sundbäck, J., Harris, R. A. and Kärre, K., Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers. Eur. J. Immunol. 2000. 30: 300-307.
27. Yu, Y. Y., George, T., Dorfman, J. R., Roland, J., Kumar, V. and Bennett, M., The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts. Immunity 1996. 4: 67-76.
28. Matsukawa, A., Hogaboam, C. M., Lukacs, N. W. and Kunkel, S. L., Chemokines and innate immunity. Rev. Immunogenet. 2000. 2: 339-358.
29. Diefenbach, A., Jensen, E. R., Jamieson, A. M. and Raulet, D. H., Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 2001. 413: 165-171.
30. Cerwenka, A., Baron, J. L. and Lanier, L. L., Ectopic expression of retinoid acid early inducible-1 gene (Rae-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. USA 2001. 98: 11521-11526.
31. Mason, L. H., Ortaldo, J. R., Young, H. A., Kkumar, V., Bennett and Andersson, S. K., Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2). J. Exp. Med. 1995. 182: 293-303.
32. Karlhofer, F. M., Ribaudo, R. K. and Yokoyama, W. M., MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells. Nature 1992. 358: 66-70.
33. Tomasello, E., Desmoulins, P. O., Chemin, K., Guia, S., Cremer, H., Ortaldo, J., Love, P., Kaiserlian, D. and Vivier, E., Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 2000. 13: 355-364.
34. Raziuddin, A., Longo, D. L., Mason, L., Ortaldo, J. R., Bennett, M. and Murphy, W. J., Differential effects of the rejection of bone marrow allografts by the depletion of activating versus inhibiting Ly-49 natural killer cell subsets. J. Immunol. 1998. 160: 87-94.
35. Ortaldo, J. R., Winkler-Pickett, R., Wililette-Brown, J., Wange, R. L., Andersson, S. K., Palumbo, G. J., Mason, L. H. and McVicar, D. W., Structure/function relationship of activating Ly-49D and inhibitory Ly-49G2 NK receptors. J. Immunol. 1999. 163: 5269-5277.
36. Diefenbach, A., Tomasello, E., Lucas, M., Jamiesson, A. M., Hsia, J. K., Vivier, E. and Raulet, D. H., Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 2002. 3: 1142-1149.