A modular, fully integrated ultra-high-throughput screening system based on confocal fluorescence analysis techniques

Journal of Biomolecular Screening

Volumn 8, Issue 6, 2003, Pages 648-659

  Jäger, Stefan ^a,d   Garbow, Norbert ^a   Kirsch, Achim ^a   Preckel, Hartwig ^a   Gandenberger, Frank U ^a   Herrenknecht, Kurt ^a   Rüdiger, Martin ^b   Hutchinson, Jonathan P ^b   Bingham, Ryan P ^b   Ramon, Fernando ^c   Bardera, Ana ^c   Martin, Julio ^c  

^a Evotec OAI   (Germany)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GLAXOSMITHKLINE   (Spain)

^d EVOTEC UK LTD   (United Kingdom)

Author keywords

Cell imaging; Cellular assay; Confocal optics; Fluorescence; High throughput screening; Homogenous assay; Integrated screening system; Single molecule detection

Indexed keywords

ANTIBIOTIC AGENT; GLYCOPROTEIN P INHIBITOR; TRACER; VERAPAMIL; ANTIINFECTIVE AGENT; LIGAND; PEPTIDE; PROTEIN;

ARTICLE; BIOTECHNOLOGY; CONFOCAL FLUORESCENCE ANALYSIS TECHNIQUE; CONTROLLED STUDY; DRUG DESIGN; DRUG INDUSTRY; DRUG SCREENING; DRUG TARGETING; EMBRYO; FLUORESCENCE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN GENOME; IMAGE ANALYSIS; INSTRUMENT; PRIORITY JOURNAL; RELIABILITY; SENSITIVITY ANALYSIS; TECHNIQUE; CELL DEATH; CELL LINE; CELL STRAIN U937; CELL SURVIVAL; COMPUTER; CONFOCAL MICROSCOPY; DRUG CONTAMINATION; DRUG EFFECT; IC 50; INSTRUMENTATION; METHODOLOGY; RIBOSOME; SENSITIVITY AND SPECIFICITY;

ANTI-BACTERIAL AGENTS; CELL DEATH; CELL LINE; CELL SURVIVAL; COMPUTERS; DRUG CONTAMINATION; DRUG EVALUATION, PRECLINICAL; FLUORESCENCE; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MICROSCOPY, CONFOCAL; PEPTIDES; PROTEINS; RIBOSOMES; SENSITIVITY AND SPECIFICITY; U937 CELLS;

EID: 3242722358     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057103258475     Document Type: Article

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