Synthesis of 2-oxopurine adducts with structural resemblance to Efavirenz and DPC 961 as potential NNRT-inhibitors

Arkivoc

Volumn 2001, Issue 10, 2001, Pages 35-45

  Andresen, Geir ^a   Gundersen, Lise Lotte ^a   Rise, Frode ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

1,9 BIS[(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 1,3,6,9 TETRAHYDRO 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 1,9 DIBENZYL 1,3,6,9 TETRAHYDRO 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 1,9 DIBENZYL 1,9 DIHYDRO 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 1,9 DIBENZYL 6 CYCLOPROPYLETHYNYL 1,3,6,9 TETRAHYDRO 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 1,9 DIHYDRO 1,9 BIS[(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 1,9 DIHYDRO 1,9 BIS[(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 8 PHENYL 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 6 CHLORO 4 CYCLOPROPYLETHYNYL 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; 6 CYCLOPROPYLETHYNYL 1,3,6,7 TETRAHYDRO 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 6 CYCLOPROPYLETHYNYL 1,9 BIS[(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 1,3,6,9 TETRAHYDRO 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 6 CYCLOPROPYLETHYNYL 1,9 BIS[(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 8 PHENYL 1,3,6,9 TETRAHYDRO 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 6 CYCLOPROPYLETHYNYL 1,9 DIBENZYL 1,3,6,9 TETRAHYDRO 2H PURIN 2 ONE; 6 CYCLOPROPYLETHYNYL 1,9 DIBENZYL 1,9 DIHYDRO 2H PURIN 2 ONE; 6 CYCLOPROPYLETHYNYL 1,9 DIHYDRO BIS[(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 2H PURIN 2 ONE; 6 CYCLOPROPYLETHYNYL 8 PHENYL 1,3,6,7 TETRAHYDRO 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; 8 BROMO 1,9 DIHYDRO 1,9 BIS[(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 6 TRIFLUOROMETHYL 2H PURIN 2 ONE; BROMINE DERIVATIVE; CYCLOPROPYLETHYNYLMAGNESIUM BROMIDE; EFAVIRENZ; PURINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SILANE DERIVATIVE; TRIMETHYL(TRIFLUOROMETHYL)SILANE; UNCLASSIFIED DRUG;

ADDITION REACTION; ALKYLATION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 3242715227     PISSN: 14246376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

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18. For other examples of Suzuki couplings on halopurines see: Havelkova, M., Hocek, M.; Cesnek, M.; Dvorak, D. Synlett 1999, 7, 1145; Hocek, M.; Holy, A.; Votruba, I.; Dvorakova, H. J. Med. Chem. 2000, 43, 1817; Cesnek, M.; Hocek, M.; Holy, A. Coll. Czech. Chem. Commun. 2000, 65, 1357.
19. For other examples of Suzuki couplings on halopurines see: Havelkova, M., Hocek, M.; Cesnek, M.; Dvorak, D. Synlett 1999, 7, 1145; Hocek, M.; Holy, A.; Votruba, I.; Dvorakova, H. J. Med. Chem. 2000, 43, 1817; Cesnek, M.; Hocek, M.; Holy, A. Coll. Czech. Chem. Commun. 2000, 65, 1357.
20. For other examples of Suzuki couplings on halopurines see: Havelkova, M., Hocek, M.; Cesnek, M.; Dvorak, D. Synlett 1999, 7, 1145; Hocek, M.; Holy, A.; Votruba, I.; Dvorakova, H. J. Med. Chem. 2000, 43, 1817; Cesnek, M.; Hocek, M.; Holy, A. Coll. Czech. Chem. Commun. 2000, 65, 1357.
21. For other examples of Pd-catalyzed coupling between halopurines and other organometallic reagents, see: Langli, G.; Gundersen, L.-L.; Rise, F. Tetrahedron, 1996, 52, 5625, and references therein; Nolsøe, J. M. J.; Gundersen, L.-L.; Rise, F. Acta Chem. Scand. 1999, 53, 366.
22. For other examples of Pd-catalyzed coupling between halopurines and other organometallic reagents, see: Langli, G.; Gundersen, L.-L.; Rise, F. Tetrahedron, 1996, 52, 5625, and references therein; Nolsøe, J. M. J.; Gundersen, L.-L.; Rise, F. Acta Chem. Scand. 1999, 53, 366.