Type II 11β-hydroxysteroid dehydrogenase expression in human colonic epithelial cells of inflammatory bowel disease

Digestive Diseases and Sciences

Volumn 44, Issue 12, 1999, Pages 2516-2522

  Takahashi, Ken Ichi ^a,b   Fukushima, Kouhei ^a,b   Sasano, Hironobu ^a,b   Sasaki, Iwao ^a,b   Matsuno, Seiki ^a,b   Krozowski, Zygmunt S ^a,b   Nagura, Hiroshi ^a,b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Colon; Crohn's disease; Type II 11 hydroxysteroid dehydrogenase; Ulcerative colitis

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; HYDROCORTISONE; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; SODIUM; WATER; HSD11B2 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; CROHN DISEASE; ENTERITIS; ENZYME SPECIFICITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE EPITHELIUM CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM ABSORPTION; ULCERATIVE COLITIS; WATER ABSORPTION; CELL CULTURE; COLON; ENZYMOLOGY; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NORTHERN BLOTTING;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ADOLESCENT; ADULT; BLOTTING, NORTHERN; CELLS, CULTURED; CHILD; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; EPITHELIAL CELLS; FEMALE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASES; MALE; MIDDLE AGED; RNA, MESSENGER;

EID: 0033233181     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026699324927     Document Type: Article

References (28)

1. 1. Mayer L, Eisenhardt D, Salomon P, Bauer W, Plous R, Piccinini L: Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease. Gastroenterology 100:3-12, 1991
2. 2. Gibson P, Rosella O: Interleukin 8 secretion by colonic crypt cells in vitro: Response to injury suppressed by butyrate and enhanced in inflammatory bowel disease. Gut 37:536-543, 1995
3. 3. Kusugami K, Fukatsu A, Tanimoto M, Shinoda M, Haruta J, Kuroiwa A, Ina K, Kanayama K, Ando T, Matsuura T, Yamaguchi T, Morise K, Ieda M, Iokawa H, Ishihara A, Sarai S: Elevation of interleukin-6 in inflammatory bowel disease is macrophage-and epithelial cell-dependent. Dig Dis Sci 40:949-959, 1995
4. 4. Fukushima K, Fiocchi C: Decreased frequency of mitochondrial DNA deletions in epithelial cells from active ulcerative colitis. Gastroenterology 108:A688, 1995
5. 5. Roediger WEW: The colonic epithelium in ulcerative colitis: An energy-deficiency disease? Lancet 2:712-715, 1980
6. 6. Kameyama J, Narui H, Inui M, Sato T: Energy level in large intestinal mucosa in patients with ulcerative colitis. Tohoku J Exp Med 143:253-254, 1984
7. 7. Das KM, Dasgupta A, Mandal A, Geng X: Autoimmunity to cytoskeletal protein tropomyosin. J Immunol 150:2487-2493, 1993
8. 8. Hollander D, Vadheim CM, Brettholz E, Petersen GM, Delahunty T, Rotter JI: Increased permeability in patients with Crohn's disease and their relatives. Ann Intern Med 105:883-885, 1986
9. 9. Traynor TR, Brown DR, O'Grady SM: Effects of inflammatory mediators on electrolyte transport across the porcine distal colon epithelium. J Pharmacol Exp Ther 264:61-66, 1993
10. 10. Percy WH, Burton MB, Glaws WR, Rose K, Burakoff R: Pharmacological basis of contractile effects of peptidoleukotrienes on rabbit colonic muscularis mucosae. Am J Physiol 264:G81-G85, 1993
11. 11. Hawker PC, McKey JS, Turnberg LA: Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease. Gastroenterology 79:508-511, 1980
12. 12. Sandle GI, Higgs N, Crowe P, Marsh MN, Venkatesan S, Peters TJ: Cellular basis for defective electrolyte transport in inflamed human colon. Gastroenterology 99:97-105, 1990
13. 13. Levitan R, Ingelfinger FJ: Effect of d-aldosterone on salt and water absorption from the intact human colon. J Clin Invest 44:801-808, 1965
14. 14. Sandle GI, Binder HJ: Corticosteroids and intestinal ion transport. Gastroenterology 93:188-196, 1987
15. 15. Krozowski ZS, Funder JW: Renal mineralocorticoid receptors and hippocampal cortisone-binding species have identical intrinsic steroid specificity. Proc Natl Acad Sci USA 80:6056-6060, 1983
16. 16. Edward CR, Stewart PM, Burt D, Brett L, McIntyre MA, Sutanto WS, deKloet ER, Monder C: Localization of 11 beta-hydroxysteroid dehydrogenase - tissue specific protector of the mineralocorticoid receptor. Lancet 2:986-989, 1988
17. 17. Funder JW, Pearce PT, Smith R, Smith AI: Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated. Science 242:583-585, 1988
18. 18. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS: Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105:R11-R17, 1994
19. 19. Smith RE, Maguire JA, Stein-Oakley AN, Sasano H, Takahashi K, Fukushima K, Krozowski ZS: Localization of 11 beta-hydroxysteroid dehydrogenase type II in human epithelial tissues. J Clin Endocrinol Metabol 81:3244-3248, 1996
20. 20. Hirasawa G, Sasano H, Takahashi K, Fukushima K, Suzuki T, Hiwatashi N, Toyota T, Krozowski ZS, Nagura H: Colocalization of 11 beta-Hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human epithelia. J Clin Endocrinol Metab 82:3859-3863, 1997
21. 21. Matts SGF: The value of rectal biopsy in the diagnosis of ulcerative colitis. Q J Med 120:393-407, 1961
22. 22. Kimura M, Masuda T, Hiwatashi N, Toyota T, Nagura H: Changes in neuropeptide-containing nerves in human colonic mucosa with inflammatory bowel disease. Pathol Intern 44:624-634, 1994
23. 23. Youngman KR, Simon PL, West GA, Cominelli F, Rachmilewitz D, Klein JS, Fiocchi C: Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells. Gastroenterology 104:749-758, 1993
24. 24. Ponte P, Ng SY, Engel J, Gunning P, Kedes L: Evolutionary conservation in the untranslated regions of action mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Res 12:1687-1696, 1984
25. 25. Fukushima K, Sasaki I, Hasegawa H, Takahashi K, Naito H, Funayama Y, Matsuno S: Sodium butyrate-induced liver-type alkaline phosphatase activity in a small intestinal epithelial cell line, IEC6. Dig Dis Sci 43:1116-1123, 1998
26. 26. Calvo CF, Chavanel G, Senik A: Substance P enhances IL-2 expression in activated human T cells. J Immunol 148:3498-3504, 1992
27. 27. Allan A, Bristol JB, Williamson RCN: Crypt cell production in ulcerative proctocolitis: Differential increments in remission and relapse. Gut 26:999-1003, 1985
28. 28. Eastwood GL, Trier JS: Epithelial cell renewal in cultured rectal biopsies in ulcerative colitis. Gastroenterology 64:383-390, 1973