Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 282, Issue 2 45-2, 2002, Pages

  Renes, Ingrid B ^a,b   Boshuizen, Jos A ^a   Van Nispen, Daniëlle J P M ^a   Bulsing, Nathalie P ^a   Büller, Hans A ^a   Dekker, Jan ^a   Einerhand, Alexandra W C ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Goblet cells; Muc2 sulfation; Mucin labeling; Proximal and distal colon

Indexed keywords

DEXTRAN SULFATE; MUCIN 2;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; COLITIS; CONTROLLED STUDY; DESCENDING COLON; DISEASE ACTIVITY; EXCISION; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; RNA ANALYSIS; TISSUE HOMOGENATE; TISSUE REGENERATION;

EID: 0036080443     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00229.2001     Document Type: Article

References (29)

1. Actions of sulphasalazine and analogues in animal models of experimental colitis
2. Experimental colitis induced by dextran sulphate sodium in mice: Beneficial effects of sulphasalazine and olsalazine
3. Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats
4. Clinicopathologic study of dextran sulfate sodium experimental murine colitis
5. Covalent oligomerization of rat gastric mucin occurs in the rough endoplasmic reticulum, is N-glycosylation-dependent, and precedes initial O-glycosylation
6. Quantitation of biosynthesis and secretion of mucin using metabolic labeling
7. Regional distribution and alterations of lectin binding to colorectal mucin in mucosal biopsies from controls and subjects with inflammatory bowel diseases
8. Mucin depletion in inflammatory bowel disease
9. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin
10. Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes
11. Sulfomucins in the human body
12. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
13. Increased rate of sialylation of colonic mucin by cultured ulcerative colitis mucosal explants
14. Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis
15. Sulphation of colonic and rectal mucin in inflammatory bowel disease: Reduced sulphation of rectal mucus in ulcerative colitis
16. Colonic sulfide in pathogenesis and treatment of ulcerative colitis
17. Mucin-type glycoproteins
18. Biosynthesis of rat Muc 2 in colon and its analogy with human Muc2
19. Biosynthesis of human colonic mucin: Muc 2 is the prominent secretory mucin
20. Preparation of anti-mucin polypeptide antisera to study mucin biosynthesis
21. Quantitative analysis of Muc2 synthesis in ulcerative colitis
22. Identification of mucins using metabolic labeling, immunoprecipitation, and gel electrophoresis
23. Mucin gene structure and expression: Protection vs. adhesion
24. Gastrointestinal expression and partial cDNA cloning of murine Muc 2
25. Sulphation and secretion of the predominant secretory human colonic mucin Muc2 in ulcerative colitis
26. Selective sparing of goblet cells and paneth cells in the intestine of methotrexate-treated rats