T-cell activation occurs simultaneously in local and peripheral lymphoid tissue following oral administration of a range of doses of immunogenic or tolerogenic antigen although tolerized T cells display a defect in cell division

Immunology

Volumn 106, Issue 2, 2002, Pages 144-158

  Smith, Karen M ^a   Davidson, Joanne M ^a   Garside, Paul ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD45 ANTIGEN; CD69 ANTIGEN; CHOLERA TOXIN; OVALBUMIN; PADGEM PROTEIN;

ACTIVE IMMUNIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL DIVISION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EFFECTOR CELL; IMMUNE SYSTEM; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; INTESTINE LYMPHATIC TISSUE; LAMINA PROPRIA; LYMPHOCYTE CLONE; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; LYMPHOID TISSUE; MALE; MEMORY CELL; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PEYER PATCH; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VACCINE PRODUCTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OVALBUMIN; T-LYMPHOCYTE SUBSETS;

EID: 0036278333     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2002.01427.x     Document Type: Article

References (31)

1. Orally induced tolerance generates an efferently acting suppressor T cell and an acceptor T cell that together down-regulate contact sensitivity
2. The immunological consequences of feeding cholera toxin. I. Feeding cholera toxin suppresses the induction of systemic delayed-type hypersensitivity but not humoral immunity
3. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments
4. Inhibition of specific immune responses by feeding protein antigens. IV. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin
5. Immunological responses to fed protein antigens in mice. I. Reversal of oral tolerance to ovalbumin by cyclophosphamide
6. Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization
7. The mechanism of cholera toxin adjuvanticity
8. Oral tolerance in disease
9. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
10. Visualizing the T-cell response elicited by oral administration of soluble protein antigen
11. Antigen-specific T cell activation and proliferation during oral tolerance induction
12. Enteric infection acts as an adjuvant for the response to a model food antigen
13. + T cells
14. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen
15. lo thymocytes in vivo
16. + T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo
17. Induction of oral tolerance in the primed immune system: Influence of antigen persistence and adjuvant form
18. Generation of anergic and potentially immunoregulatory CD25 (+) CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen
19. Determination of lymphocyte division by flow cytometry
20. + T-cell memory, CD45R subsets and the persistence of antigen - A unifying concept
21. Selective migration of lymphocytes within the mouse small intestine
22. Thymus-dependent and thymus-independent populations, origin, migratory patterns and lifespan
23. Molecules controlling lymphocyte migration to the gut
24. The generation of a 'tolerogen' after the ingestion of ovalbumin is time-dependent and unrelated to serum levels of immunoreactive antigen
25. Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo
26. CTLA-4 regulates induction of anergy in vivo
27. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
28. + T cell tolerance induction versus priming is independent of the rate and number of cell divisions
29. The CD69 receptor: A multipurpose cell-surface trigger for hematopoietic cells
30. Direct measurement of anergy of antigen-specific T cells following oral tolerance induction
31. The anatomical basis of intestinal immunity