Phenotypical characterisation of the isolated Norfolk Island population focusing on epidemiological indicators of cardiovascular disease

Human Heredity

Volumn 60, Issue 4, 2006, Pages 211-219

  Bellis, Claire ^a   Hughes, Roger M ^a   Begley, Kimberly N ^a   Quinlan, Sharon ^a   Lea, Rod A ^a   Heath, Simon C ^b   Blangero, John ^c   Griffiths, Lyn R ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Cardiovascular disease; Isolated population; Linkage disequilibrium; Norfolk island; Quantitative trait loci

Indexed keywords

CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; AUSTRALIA; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUCASIAN; CONTROLLED STUDY; FEMALE; GENE MAPPING; HERITABILITY; HUMAN; HYPERTENSION; MALE; MATHEMATICAL COMPUTING; NORFOLK ISLAND; OBESITY; PHENOTYPE; POPULATION GENETICS; PREVALENCE; PROGENY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AUSTRALIA; CARDIOVASCULAR DISEASES; CHROMOSOME MAPPING; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; HUMANS; MALE; MIDDLE AGED; MODELS, GENETIC; PEDIGREE; QUANTITATIVE TRAIT LOCI; RISK FACTORS;

EID: 31844440483     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000090545     Document Type: Article

References (44)

1. Shmulewitz D, Auerbach SB, Lehner T, et al: Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Hum Hered 2001;51:8-19.
2. Kannel WB: The Framingham Study: ITS 50-year legacy and future promise. J Atheroscler Thromb 2000;6:60-66.
3. Han Z, Heath SC, Shmulewitz D, et al: Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. Am J Med Genet 2002;110:234-242.
4. Wijsman EM, Rosenthal EA, Hall D, et al: Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: Evidence for linkage to chromosome 2q. Mol Psychiatry 2003;8:695-705, 643.
5. Helgason A, Nicholson G, Stefansson K, Donnelly P: A reassessment of genetic diversity in Icelanders: Strong evidence from multiple loci for relative homogeneity caused by genetic drift. Ann Hum Genet 2003;67:281-297.
6. Gulcher J, Stefansson K: Population genomics: Laying the groundwork for genetic disease modeling and targeting. Clin Chem Lab Med 1998;36:523-527.
7. Eaves IA, Merriman TR, Barber RA, et al: The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nat Genet 2000;25:320-323.
8. Varilo T, Paunio T, Parker A, et al: The interval of linkage disequilibrium (LD) detected with microsatellite and SNP markers in chromosomes of Finnish populations with different histories. Hum Mol Genet 2003;12:51-59.
9. Peltonen L, Jalanko A, Varilo T: Molecular genetics of the Finnish disease heritage. Hum Mol Genet 1999;8:1913-1923.
10. Wessman M, Kallela M, Kaunisto MA, et al: A susceptibility locus for migraine with aura, on chromosome 4q24. Am J Hum Genet 2002;70:652-662.
11. Angius A, Bebbere D, Petretto E, et al: Not all isolates are equal: linkage disequilibrium analysis on Xq13.3 reveals different patterns in Sardinian sub-populations. Hum Genet 2002;111:9-15.
12. Angius A, Petretto E, Maestrale GB, et al: A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search. Am J Hum Genet 2002;71:893-905.
13. Angius A, Melis PM, Morelli L, et al: Archival, demographic and genetic studies define a Sardinian sub-isolate as a suitable model for mapping complex traits. Hum Genet 2001;109:198-209.
14. Hoare M: Norfolk Island: A Revised and Enlarged History 1774-1998. Rockhampton: Central Queensland University Press, 1999.
15. Edgecombe J: Norfolk Island - South Pacific: Island of History and Many Delights. Thornleigh, Australia: J.M. Edgecombe, 1999.
16. Ober C, Abney M, McPeek MS: The genetic dissection of complex traits in a founder population. Am J Hum Genet 2001;69:1068-1079.
17. Dunning AM, Durocher F, Healey CS, et al: The extent of linkage disequilibrium in four populations with distinct demographic histories. Am J Hum Genet 2000;67:1544-1554.
18. de la Chapelle A, Wright FA: Linkage disequilibrium mapping in isolated populations: The example of Finland revisited. Proc Natl Acad Sci USA 1998;95:12416-12423.
19. Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988;37:1595-1607.
20. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
21. Refshauge WF, Walsh RJ: Pitcairn Island: fertility and population growth, 1790-1856. Ann Hum Biol 1981;8:303-312.
22. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-1211.
23. Haseman JK, Elston RC: The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972;2:3-19.
24. Blangero J, Almasy L: Multipoint oligogenic linkage analysis of quantitative traits. Genet Epidemiol 1997;14:959-964.
25. Amos CI: Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 1994;54:535-543.
26. Goldgar DE: Multipoint analysis of human quantitative genetic variation. Am J Hum Genet 1990;47:957-967.
27. Schork NJ: Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet 1993;53:1306-1319.
28. Comuzzie AG, Hixson JE, Almasy L, et al: A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 1997;15:273-276.
29. Blangero J: Statistical genetic approaches to human adaptability. Hum Biol 1993;65:941-966.
30. Towne B, Siervogel RM, Blangero J: Effects of genotype-by-sex interaction on quantitative trait linkage analysis. Genet Epidemiol 1997;14:1053-1058.
31. Stern MP, Duggirala R, Mitchell BD, et al: Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans. Genome Res 1996;6:724-734.
32. Duggirala R, Blangero J, Almasy L, et al: Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 1999;64:1127-1140.
33. Williams JT, Blangero J: Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples. Genet Epidemiol 1999;16:113-134.
34. Almasy L, Dyer TD, Blangero J: Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages. Genet Epidemiol 1997;14:953-958.
35. Williams JT, Van Eerdewegh P, Almasy L, Blangero J: Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. Am J Hum Genet 1999;65:1134-1147.
36. Williams JT, Duggirala R, Blangero J: Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees. Genet Epidemiol 1997;14:1065-1070.
37. Blangero J, Williams JT, Almasy L: Robust LOD scores for variance component-based linkage analysis. Genet Epidemiol 2000;19 (suppl 1):S8-S14.
38. Blangero J, Williams JT, Almasy L: Variance component methods for detecting complex trait loci. Adv Genet 2001;42:151-181.
39. AIHW: Diabetes: Australian Facts 2002. Canberra, Australia: Australian Institute of Health and Welfare, 2002.
40. AIHW: Australia's Health 2000: The Seventh Biennial Health Report of the AIHW. Canberra: Australian Institute of Health and Welfare, 2000.
41. NHMRC: Australian Alcohol Guidelines: Health Risks and Benefits. Canberra: National Health and Medical Research Council, 2001.
42. Bunker SJ, Colquhoun DM, Esler MD, et al: 'Stress' and coronary heart disease: Psychosocial risk factors. Med J Aust 2003;178:272-276.
43. McQueen MB, Bertram L, Rimm EB, Blacker D, Santangelo SL: A QTL genome scan of the metabolic syndrome and its component traits. BMC Genet 2003;4(suppl 1):S96.
44. Adeyemo AA, Omotade OO, Rotimi CN, Luke AH, Tayo BO, Cooper RS: Heritability of blood pressure in Nigerian families. J Hypertens 2002;20:859-863.