Effects of pentoxifylline, pentifylline and γ-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts

Nephrology Dialysis Transplantation

Volumn 15, Issue 10, 2000, Pages 1535-1546

  Strutz, Frank ^a   Heeg, Malte ^a   Kochsiek, Tobias ^a   Siemers, Gesa ^a   Zeisberg, Michael ^a   Müller, Gerhard A ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

FGF 2; Fibroblasts; Kidney fibrosis; Pentifylline; Pentoxifylline; interferon

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ACTIN; BASIC FIBROBLAST GROWTH FACTOR; BROXURIDINE; COLLAGEN TYPE 1; FIBRONECTIN; GAMMA INTERFERON; PENTIFYLLINE; PENTOXIFYLLINE; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FETAL CALF SERUM; FIBROBLAST; FIBROBLAST CULTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN VITRO STUDY; KIDNEY BIOPSY; KIDNEY CELL; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY FUNCTION; MALE; MYOFIBROBLAST; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; WESTERN BLOTTING;

EID: 0033810053     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/15.10.1535     Document Type: Article

References (49)

1. The pathogenesis of chronic renal failure in the primary glomerulopathies, renal vasculopathies, and chronic interstitial nephritides
2. Renal fibrosis: Insights into pathogenesis and treatment
3. Pathophysiology of progressive nephropathies
4. The tubulointerstitium in progressive renal disease
5. Identification and characterization of fibroblast-specific protein 1 (FSP1)
6. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats
7. Characterization of human renal fibroblasts in health and disease: I. Immunophenotyping of cultured tubular epithelial cells and fibroblasts derived from kidneys with histologically proven interstitial fibrosis
8. Molecular insights into renal interstitial fibrosis
9. Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: Evidence for mediation by nuclear factor 1 down-regulation
10. Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphoea skin and their production of collagen, glycosaminoglycans and fibronectin
11. Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity
12. Pentoxifylline inhibits the proliferation and glycosaminoglycan synthesis of cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial myxoedema
13. Effect of pentoxifylline on the fibrogenic funtions of cultured rat liver fat-storing cells and myofibroblasts
14. Pentoxifylline. A review of its pharmocodynamic and pharmacokinetic properties and its therapeutic efficacy
15. Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts
16. Antifibrotic effect of pentoxifylline in rat biliary fibrosis due to bile duct obstruction
17. Vasodilator agents modulate rat glomerular mesangial cell growth and collagen synthesis
18. Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis
19. γ interferon is the lymphokine and β interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation
20. Interferon-γ reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor-β in normal human fibroblasts
21. Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma
22. Treatment of systemic sclerosis with g-interferon
23. A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis
24. Human renal fibroblast cell lines (tFKIF and tNKF) are new tools to investigate pathophysiologic mechanisms of renal interstitial fibrosis
25. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication
26. Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes
27. Reduction of background problems in nonradioactive northern and southern blot analyses enables higher sensitivity than 32P-based hybridizations
28. Basic fibroblast growth factor (FGF-2) expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation
29. Mesangial cells from transgenic mice with progressive glomerulosclerosis exhibit stable, phenotypic changes including undetectable MMP-9 and increased type IV collagen
30. Labels, labeling, analytical strategies, and applications
31. Renal fibroblast heterogeneity
32. Fibroblasts of rabbit kidney in culture II. Paracrine stimulation of papillary fibroblasts by PDGF
33. Paracrine stimulation of human renal fibroblasts by proximal tubule cells
34. Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis
35. Platelet-derived growth factor and pentoxifylline modulation of collagen synthesis in myofibroblasts
36. Pentoxifylline does not prevent the cytokine-induced first dose reaction following OKT3-a randomized, double-blind placebo-controlled study
37. Kinetics of intravenous and oral pentoxifylline in healthy subjects
38. Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells
39. Comparative study on effects of pentoxifylline, prednisolone and colchicine in experimental alveolitis
40. Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: An experimental study
41. Striking regression of radiation-induced fibrosis by a combination of pentoxifylline and tocopherol
42. A multicenter trial of recombinant human interferon gamma in patients with systemic sclerosis: Effects on cutaneous fibrosis an interleukin 2 receptor levels
43. Growth factors and cytokines
44. IFN-gamma induces the high-affinity Fc receptor I for IgG (CD64) on human glomerular mesangial cells
45. IFN-gamma mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis
46. Modulation of experimental mesangial proliferative nephritis by interferon-gamma
47. Extrarenal cytokines modulate the glomerular response to IgA immune complexes
48. Interferon gamma inhibits lipocyte activation and extracellular matrix mRNA expression during experimental liver injury: Implications for treatment of hepatic fibrosis
49. Interleukin-4 and interferon-γ discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets