Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: Implications for structural differences in macular profiles

Experimental Eye Research

Volumn 82, Issue 5, 2006, Pages 798-806

  Patel, Jignesh I ^a,b   Tombran Tink, Joyce ^c,d   Hykin, Phil G ^b   Gregor, Zdenek J ^b   Cree, Ian A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aqueous; Diabetic macular oedema; Growth factors; HGF; OCT; PEDF; VEGF; Vitreous

Indexed keywords

CANCER GROWTH FACTOR; GELATINASE B; PIGMENT EPITHELIUM DERIVED FACTOR; SCATTER FACTOR; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

ADULT; AGED; AQUEOUS HUMOR; ARTICLE; CILIARY DISK; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; OPTICAL TOMOGRAPHY; PRIORITY JOURNAL; RETINA MACULA EDEMA; UPREGULATION; VITRECTOMY; VITREOUS BODY;

EID: 31644440270     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2005.10.002     Document Type: Article

References (35)

1. L. Aiello, R. Avery, P. Arrigg, B. Keyt, and S. Shah Vascular endotheilal growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders N. Engl. J. Med. 331 1994 1480 1487
2. L. Aiello, M. Cahill, and J. Cavaallerano Growth factors and protein kinase C inhibitors as novel therapies for the medical management of diabetic retinopathy Eye 18 2004 117 125
3. R. Amin, R. Frank, A. Kennedy, D. Eliott, J. Puklin, and G. Abrams Vascular endothelial growth factor is present in glial cells of the retina and the optic nerve of human subjects with nonproliferative diabetic retinopathy Invest. Ophthalmol. Vis. Sci. 38 1997 36 47
4. D. Antonetti, A. Barber, S. Khin, E. Leith, J. Tarbell, and T. Gardner Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group Diabetes 47 1998 1953 1959
5. D. Antonetti, A. Barber, L. Hollinger, E. Wolpert, and T. Gardner Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors J. Biol. Chem. 274 1999 23463 23467
6. M. Behzadian, X.-L. Wang, L. Windsor, N. Ghaly, and R. Caldwell TGF-β increases retinal endothelial cell permeabiltiy by increasing MMP-9: possible role of glial cells in endothelial barrier function Invest. Ophthalmol. Vis. Sci. 42 2001 853 859
7. W. Border, and N. Noble Transforming growth factor beta in tissue fibrosis N. Engl. J. Med. 331 1994 1286 1292
8. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
9. W. Cai, S. Rook, Z. Jiang, N. Takahara, and L. Aiello Mechanisms of hepatocyte growth ractor-induced retinal endothelial cell migration and growth Invest. Ophthalmol. Vis. Sci. 41 2000 1885 1893
10. J. Clark, R. Grey, K. Lim, and C. Burns-Cox Loss of vision before ophthalmic referral in blind and partially sighted diabetics in Bristol Br. J. Ophthalmol. 78 1994 741 744
11. J. Cunha-Vaz, J. Abreu, A. Campo, and G. Figo Early breakdown of the blood-retinal barrier in diabetes Br. J. Ophthalmol. 59 1975 649 656
12. D. Dawson, O. Volpert, and P. Gillis Pigment epithelium-derived factor: a potent inhibitor of angiogenesis Science 285 1999 245 248
13. G. Duguid, P. Massin, B. Haouchine, A. Erginay, and A. Gaudric Vitrectomy for diabetic macular oedema: the effect on visual acuity and optical coherence tomography (OCT) appearances Invest. Ophthalmol. Vis. Sci. 41 2000 585
14. N. Ferrara Vascular endothelial growth factor and the regulation of angiogenesis Recent Prog. Horm. Res. 55 2000 15 35
15. H. Funatsu, H. Yamashita, T. Ikeda, Y. Nakanishi, S. Kitano, and S. Hori Angiotensin II and vascular endothelial groth factor in the vitreous fluid of patients with diabetic macular edema and other retinal disorders Am. J. Ophthalmol. 133 2002 537 543
16. H. Funatsu, H. Yamashita, H. Noma, T. Mimura, T. Yamashita, and S. Hori Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humour of diabetics with macular edema Am. J. Ophthalmol. 133 2002 70 77
17. H. Funatsu, H. Yamashita, H. Noma, T. Mimura, S. Nakamura, K. Sakata, and S. Hori Aqueous humour levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients Grafe's Arch. Clin. Exp. Ophthalmol. 243 2005 3 8
18. P. Gehlbach, S. Yamamoto, T. Deering, W. Xiao, and E. Duh Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier Hum. Genet. Ther. 14 2003 129 141
19. A. Giovannini, G. Amato, C. Mariotti, and B. Scassellati-Sforzolini Optical coherence tomography findings in diabetic macular edema before and after vitrectomy Ophthalmic. Surg. Lasers 31 2000 187 191
20. K. Harkness, P. Adamson, J. Sussman, C. Davies-Jones, J. Greenwood, and M. Woodroofe Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium Brain 123 2000 698 709
21. Y. He, S. Smith, K. Day, D. Clark, D. Licence, and D. Charnock-Jones Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity Mol. Endocrinol. 13 1999 537 545
22. T. Hikichi, N. Fuijo, J. Akiba, Y. Azuma, M. Takahashi, and A. Yoshida Association between the short-term natural history of diabetic macular edema and the vitreomacular relationship in type II diabetes mellitus Ophthalmology 104 1997 473 478
23. Y. Ikuno, and A. Kazlauskas TGF β1-dependent contraction of fibroblasts is mediated by the PDGFα receptor Invest. Ophthalmol. Vis. Sci. 43 2002 41 46
24. W. Jiang, T. Martin, K. Matsumoto, T. Nakamura, and R. Mansel Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells J. Cell. Physiol. 181 1999 319 329
25. M. Jin, K. Kashiwagi, Y. Iizuka, Y. Tanaka, M. Imai, and Tsukahara Matrix metalloproteinases in human diabetic and nondiabetic vitreous Retina 21 28-33 2001
26. Y. Katsura, T. Okana, and M. Noritake Hepatocyte growth factor in vitreous fluid of patients with proliferative diabetic retinopathy and other retinal disorders Diab. Care 21 1998 1759 1763
27. D. Kent, A. Vinores, and P. Campochiaro Macular oedema: the role of soluble mediators Br. J. Ophthalmol. 84 2000 542 545
28. Lewis The role of vitrectomy in the treatment of diabetic macular edema Ophthalmology 131 2001 123 125
29. H. Lewis, G. Abrams, M. Blumenkranz, and R. Campo Vitrectomy for diabetic macular traction edema associated with posterior hyaloidal traction Ophthalmology 99 1992 753 759
30. H. Ozaki, H. Hayashi, S. Vinores, Y. Moromizato, P. Campochiaro, and K. Oshima Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood retinal barrier in rabbits and primates Exp. Eye Res. 64 1997 505 517
31. T. Qaum, Q. Xu, A. Joussen, M. Clemens, W. Qin, and K. Miyamoto VEGF-initiated blood-retinal barrier breakdown in early diabetes Invest. Ophthalmol. Vis. Sci. 42 2001 2408 2413
32. J. Sebag, B. Buckingham, M. Charles, and K. Reiser Biochemical abnormalities in vitreous of humans with proliferative diabetic retinopathy Arch. Ophthalmol. 110 1992 1472 1476
33. M. Shibuya Structure and dual function of vascular endothelial growth factor receptor-1 (flt-1) Int. J. Biochem. Cell Biol. 33 2001 409 420
34. N. Tachi, and N. Ogino Vitrectomy for diffuse macular edema in cases of diabetic retinopathy Am. J. Ophthalmol. 122 1996 258 260
35. S. Vinores, J. Van Niel, J. Swerdoff, and P. Campochiaro Electron microscopic immunocytochemical demonstration of blood retinal barrier breakdown in human diabetics and its association with aldose reductase in retinal vascular endothelium and retinal pigment epithelium Histochem. J. 25 1993 648 663