Inhibition of interleukin-4 production in activated T cells via down-regulation of NF-AT DNA binding activity by apigenin, a flavonoid present in dietary plants

Immunology Letters

Volumn 103, Issue 2, 2006, Pages 108-114

  Park, Jin ^a,c   Kim, Seung Hyun ^a   Kim, Tae Sung ^a,b  

^a Korea University   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c Chonnam National University Medical School   (South Korea)

Author keywords

Allergy; Apigenin; Interleukin 4; NF AT; T cell

Indexed keywords

APIGENIN; DNA; FLAVONOID; INTERLEUKIN 4; NUCLEAR FACTOR;

ANIMAL CELL; ARTICLE; BASOPHIL; BINDING AFFINITY; BINDING SITE; CELL STIMULATION; CYTOKINE PRODUCTION; DNA BINDING; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; GENETIC TRANSFECTION; IMMUNE RESPONSE; INHIBITION KINETICS; LYMPH NODE CELL; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; THYMOMA;

ANIMALS; APIGENIN; BINDING SITES; CARCINOGENS; DNA; DOWN-REGULATION; FEMALE; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; NFATC TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE;

EID: 31544477689     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2005.10.002     Document Type: Article

References (40)

1. H. Wei, L. Tye, E. Bresnick, and D.F. Birt Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice Cancer Res 50 1990 499 502
2. S. Caltagirone, C. Rossi, A. Poggi, F.O. Ranelletti, P.G. Natali, and M. Brunetti Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential Int J Cancer 87 2000 595 600
3. J. Psotova, S. Chlopcikova, P. Miketova, J. Hrbac, and V. Simanek Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin Phytother Res 18 2004 516 521
4. R. Verbeek, A.C. Plomp, E.A. van Tol, and J.M. van Noort The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells Biochem Pharmacol 68 2004 621 629
5. M. Kimata, N. Inagaki, and H. Nagai Effects of luteolin and other flavonoids on IgE-mediated allergic reactions Planta Med 66 2000 25 29
6. H. Mastuda, T. Morikawa, K. Ueda, H. Managi, and M. Yoshikawa Structural requirements of flavonoids for inhibition of antigen-induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells Bioorg Med Chem 10 2002 3123 3128
7. T. Hirano, S. Higa, J. Arimitsu, T. Naka, Y. Shima, and S. Ohshima Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils Int Arch Allergy Immunol 134 2004 135 140
8. A. O'Garra Cytokines induce the development of functionally heterogenous T helper cell subsets Immunity 8 1998 275 283
9. A.B. Kay Immunomodulation in asthma: mechanisms and possible pitfalls Curr Opin Pharmacol 3 2003 220 226
10. R. Noelle, R.P. Kramme, J. Ohara, J.W. Uhr, and E.S. Vitetta Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor Proc Natl Acad Sci USA 81 1984 6149 6153
11. T. Defrance, J.P. Aubry, F. Rousset, B. Vanbervliet, J.Y. Bonnefoy, and N. Arai Human recombinant interleukin-4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes J Exp Med 165 1987 1459 1467
12. J. Ohara, and W.E. Paul Up-regulation of interleukin-4/B-cell stimulatory factor 1 receptor expression Proc Natl Acad Sci USA 85 1988 822 825
13. A. Ranger, M.R. Hodge, E.M. Gravallese, M. Oukka, L. Davidson, and F.W. Alt Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc Immunity 8 1998 125 134
14. M.H. Kaplan, U. Schindler, S.T. Smiley, and M.J. Grusby Stat6 is required for mediating responses to IL-4 and for development of Th2 cells Immunity 4 1996 313 319
15. I.C. Ho, M.R. Hodge, J.W. Rooney, and L.H. Glimsher The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4 Cell 85 1996 973 983
16. D.H. Zhang, L. Cohn, P. Ray, K. Bottomly, and A. Ray Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene J Biol Chem 272 1997 21597 21603
17. A. Faith, D.F. Richards, A. Verhoef, J.R. Lamb, T.H. Lee, and C.M. Hawrylowicz Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: relevance to immunotherapy Clin Exp Allergy 33 2003 1209 1215
18. R. Chen, T. Burke, J. Cumberland, M. Brummet, L. Beck, and V. Casolaro Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter J Immunol 164 2000 825 832
19. S.N. Georas, J.E. Cumberland, T.F. Burke, R. Chen, U. Schindler, and V. Casolaro Stat6 inhibits human interleukin-4 promoter activity in T cells Blood 92 1998 4529 4538
20. D.H. Zhang, L. Yang, and A. Ray Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3 J Immunol 161 1998 3817 3821
21. S.J. Szabo, J.S. Gold, T.L. Murphy, and K.M. Murphy Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells. Roles for NF-Y and NF-ATc Mol Cell Biol 13 1993 4793 4805
22. M. Li-Weber, P. Salgame, C. Hu, I.V. Davydov, O. Laur, and S. Klevenz Krammer PH Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter J Immunol 161 1998 1380 1389
23. + T cells through an effect on antigen-presenting cells J Immunol 154 1995 2578 2587
24. T.S. Kim, R.H. Dekruyff, R. Rupper, H.T. Maecker, S. Levy, and D.T. Umetsu An ovalbumin IL-12 fusion protein is more effective than ovalbumin plus recombinant IL-12 in inducing a T helper cell type 1-dominanted immune response and inhibiting antigen-specific IgE production J Immunol 158 1997 4137 4144
25. T.S. Kim, S.W. Chung, S.H. Kim, S.N. Kang, and B.Y. Kang Therapeutic anti-tumor response induced with epitope-pulsed fibroblasts genetically engineered for B7.1 expression and IFN-γ secretion Int J Cancer 87 2000 427 433
26. J.D. Dignam, R.M. Lebovitz, and R.G. Roeder Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Res 11 1983 1475 1489
27. + T cell clones J Exp Med 173 1991 747 750
28. R. Mandler, F.D. Finkelman, A.D. Levine, and C.M. Snapper IL-4 induction of IgE class switching by lipopolysaccharide-activated murine B cells occurs predominantly through sequential switching J Immunol 150 1993 407 418
29. E. Hamelmann, C. Rolinck-Werninghaus, and U. Wahn Is there a role for anti-IgE in combination with specific allergen immunotherapy? Curr Opin Allergy Clin Immunol 3 2003 501 510
30. P.J. Barnes Cytokine modulators as novel therapies for asthma Annu Rev Pharmacol Toxicol 42 2002 81 98
31. J.W. Steinke Anti-interleukin-4 therapy Immunol Allergy Clin North Am 24 2004 599 614
32. S. Diehl, T. Krahl, L. Rinaldi, R. Norton, C.G. Irvin, and M. Rincon Inhibition of NF-AT specifically in T cells prevents allergic pulmonary inflammation J Immunol 172 2004 3597 3603
33. T. Naofumi, K.N. Naoko, A. Naoko, A. Ken-ichi, and Y. Takashi Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activater protein-1 family proteins Int Immunol 9 1997 1329 1338
34. R.Q. Cron, S.J. Bort, Y. Wang, M.W. Brunvand, and D.B. Lewis T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells J Immunol 162 1999 860 870
35. J.W. Rooney, T. Hoey, and L.H. Glimcher Coordicate and cooperative roles for NF-AT and AP-1 in the regulation of the IL-4 gene Immunity 2 1995 473 483
36. 2+ signals and immunosuppression Nature 383 1996 837 840
37. C. Luo, E. Burgeon, J.A. Carew, P.G. McCaffrey, and T.M. Badalian Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes Mol Cell Biol 16 1996 3955 3966
38. 2+, calcineurin, and NF-AT Cell 96 1999 611 614
39. S. Romagnani Lymphokine production by human T cells in disease states Annu Rev Immunol 12 1994 227 257
40. J. Dragana, L. Zhugong, and C.G. William Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways Trends immunol 22 2001 450 457