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Volumn 33, Issue 9, 2003, Pages 1209-1215

Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: Relevance to immunotherapy

Author keywords

Allergen; Anergy; Immunotherapy; NF AT; Th2 cytokines

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; PHOSPHOLIPASE A2; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT;

EID: 0042736703     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01748.x     Document Type: Article
Times cited : (32)

References (37)
  • 1
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994; 12:227-32.
    • (1994) Annu Rev Immunol , vol.12 , pp. 227-232
    • Romagnani, S.1
  • 2
    • 0028176655 scopus 로고
    • Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
    • Zurawski G, de Vries JE. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994; 15:19-23.
    • (1994) Immunol Today , vol.15 , pp. 19-23
    • Zurawski, G.1    De Vries, J.E.2
  • 3
    • 0025805857 scopus 로고
    • T cell subsets and their soluble products regulate eosinophilia in allergic and non-allergic asthma
    • Walker C, Virchow JC, Bruijnzeel PLB, Blaser K. T cell subsets and their soluble products regulate eosinophilia in allergic and non-allergic asthma. J Immunol 1991; 145:1829-34.
    • (1991) J Immunol , vol.145 , pp. 1829-1834
    • Walker, C.1    Virchow, J.C.2    Bruijnzeel, P.L.B.3    Blaser, K.4
  • 4
    • 0033970208 scopus 로고    scopus 로고
    • The consideration of immunotherapy in the treatment of allergic asthma
    • Creticos PS. The consideration of immunotherapy in the treatment of allergic asthma. J Allergy Clin Immunol 2000; 105:559-74.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 559-574
    • Creticos, P.S.1
  • 5
    • 0032401770 scopus 로고    scopus 로고
    • Immunotherapy of allergy: Anergy, deletion, and immune deviation
    • Rolland J, O'Hehir R. Immunotherapy of allergy: anergy, deletion, and immune deviation. Curr Opin Immunol 1998; 10:640-5.
    • (1998) Curr Opin Immunol , vol.10 , pp. 640-645
    • Rolland, J.1    O'Hehir, R.2
  • 6
    • 0029820287 scopus 로고    scopus 로고
    • Epitope specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro
    • Akdis AC, Akdis M, Blesken T, Wymann D, Alkan SS, Blaser K. Epitope specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J Clin Invest 1996; 98:1676-83.
    • (1996) J Clin Invest , vol.98 , pp. 1676-1683
    • Akdis, A.C.1    Akdis, M.2    Blesken, T.3    Wymann, D.4    Alkan, S.S.5    Blaser, K.6
  • 7
    • 0031179647 scopus 로고    scopus 로고
    • Defective TCR stimulation in anergised Type 2T helper cells correlates with abrogated p561ck and ZAP-70 tyrosine kinase activities
    • Faith A, Akdis CA, Akdis M, Simon H-U, Blaser K. Defective TCR stimulation in anergised Type 2T helper cells correlates with abrogated p561ck and ZAP-70 tyrosine kinase activities. J Immunol 1997; 159:53-7.
    • (1997) J Immunol , vol.159 , pp. 53-57
    • Faith, A.1    Akdis, C.A.2    Akdis, M.3    Simon, H.-U.4    Blaser, K.5
  • 8
    • 0028887998 scopus 로고
    • Multiple kinases mediate T cell receptor signaling
    • Howe LR, Weiss A. Multiple kinases mediate T cell receptor signaling. Trends Biochem Sci 1995; 20:59-64.
    • (1995) Trends Biochem Sci , vol.20 , pp. 59-64
    • Howe, L.R.1    Weiss, A.2
  • 9
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the NF-AT family: Regulation and function
    • Rao A, Luo C, Hogan PG. Transcription factors of the NF-AT family: regulation and function. Annu Rev Immunol 1997; 15:707-47.
    • (1997) Annu Rev Immunol , vol.15 , pp. 707-747
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 10
    • 0034235929 scopus 로고    scopus 로고
    • The duration of nuclear residence of NF-AT determines the pattern of cytokine expression in human SCID T cells
    • Feske S, Draeger R, Peter H-H, Eichmann K, Rao A. The duration of nuclear residence of NF-AT determines the pattern of cytokine expression in human SCID T cells. J Immunol 2000; 165:297-305.
    • (2000) J Immunol , vol.165 , pp. 297-305
    • Feske, S.1    Draeger, R.2    Peter, H.-H.3    Eichmann, K.4    Rao, A.5
  • 11
    • 0031951071 scopus 로고    scopus 로고
    • The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production
    • Yoshida H, Mishina H, Tukimoto H et al. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 1998; 8:115-22.
    • (1998) Immunity , vol.8 , pp. 115-122
    • Yoshida, H.1    Mishina, H.2    Tukimoto, H.3
  • 12
    • 0031933037 scopus 로고    scopus 로고
    • Delayed lymphoid repopulation with defects in IL-4 driven responses produced by inactivation of NF-ATc
    • Ranger AM, Hodge MR, Gravallese EM et al. Delayed lymphoid repopulation with defects in IL-4 driven responses produced by inactivation of NF-ATc. Immunity 1998; 8:125-34.
    • (1998) Immunity , vol.8 , pp. 125-134
    • Ranger, A.M.1    Hodge, M.R.2    Gravallese, E.M.3
  • 14
    • 0031068113 scopus 로고    scopus 로고
    • Differential interaction of nuclear factors with the PRE-1 enhancer element of the human IL-4 promoter in different T cell subsets
    • Li-Weber M, Salgame P, Chenggang H, Davydov IV, Krammer PH. Differential interaction of nuclear factors with the PRE-1 enhancer element of the human IL-4 promoter in different T cell subsets. J Immunol 1997; 158:1194-200.
    • (1997) J Immunol , vol.158 , pp. 1194-1200
    • Li-Weber, M.1    Salgame, P.2    Chenggang, H.3    Davydov, I.V.4    Krammer, P.H.5
  • 15
    • 0344196985 scopus 로고    scopus 로고
    • Regulation of IL-4 expression by the transcription factor Jun B during helper cell differentiation
    • Li B, Tournier C, Davis RJ, Flavell RA. Regulation of IL-4 expression by the transcription factor Jun B during helper cell differentiation. EMBO J 1999; 18:420-32.
    • (1999) EMBO J , vol.18 , pp. 420-432
    • Li, B.1    Tournier, C.2    Davis, R.J.3    Flavell, R.A.4
  • 16
    • 0027717415 scopus 로고
    • Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp: Identification of HLA-DR and -DQ restricted T cell epitopes
    • Verhoef A, Higgins JA, Thorpe CJ et al. Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp: identification of HLA-DR and -DQ restricted T cell epitopes. Int Immunol 1993; 5:1589-97.
    • (1993) Int Immunol , vol.5 , pp. 1589-1597
    • Verhoef, A.1    Higgins, J.A.2    Thorpe, C.J.3
  • 17
    • 0031045733 scopus 로고    scopus 로고
    • The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells
    • Carballido JM, Faith A, Carballido-Perrig N, Blaser K. The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells. Eur J Immunol 1997; 27:515-21.
    • (1997) Eur J Immunol , vol.27 , pp. 515-521
    • Carballido, J.M.1    Faith, A.2    Carballido-Perrig, N.3    Blaser, K.4
  • 18
    • 0043004513 scopus 로고
    • Induction of tolerance in influenza virus immune T lymphocytes clones with synthetic peptides of influenza hemagglutinin
    • Lamb JR, Skidmore BJ, Green N, Chiller JM, Feldmann M. Induction of tolerance in influenza virus immune T lymphocytes clones with synthetic peptides of influenza hemagglutinin. J Exp Med 1983; 179:481-7.
    • (1983) J Exp Med , vol.179 , pp. 481-487
    • Lamb, J.R.1    Skidmore, B.J.2    Green, N.3    Chiller, J.M.4    Feldmann, M.5
  • 19
    • 0033846725 scopus 로고    scopus 로고
    • + T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production
    • + T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production. Eur J Immunol 2000; 30:2344-54.
    • (2000) Eur J Immunol , vol.30 , pp. 2344-2354
    • Richards, D.F.1    Fernandez, M.2    Caulfield, J.3    Hawrylowicz, C.M.4
  • 20
    • 0029126723 scopus 로고
    • Bee venom immunotherapy induces a shift in cytokine responses from a Th2 to a Th1 dominant pattern: Comparison of rush and conventional immunotherapy
    • McHugh SM, Deighton J, Stewart AG, Lachmann PJ, Ewan PW. Bee venom immunotherapy induces a shift in cytokine responses from a Th2 to a Th1 dominant pattern: comparison of rush and conventional immunotherapy. Clin Exp Allergy 1995; 25:828-38.
    • (1995) Clin Exp Allergy , vol.25 , pp. 828-838
    • McHugh, S.M.1    Deighton, J.2    Stewart, A.G.3    Lachmann, P.J.4    Ewan, P.W.5
  • 21
    • 0028919204 scopus 로고
    • Differential induction of the NF-AT complex during restimulation and the induction of T cell anergy
    • Wotton D, Higgins JA, O'Hehir RE, Lamb JR, Lake RA. Differential induction of the NF-AT complex during restimulation and the induction of T cell anergy. Hum Immunol 1995; 42:95-9.
    • (1995) Hum Immunol , vol.42 , pp. 95-99
    • Wotton, D.1    Higgins, J.A.2    O'Hehir, R.E.3    Lamb, J.R.4    Lake, R.A.5
  • 22
    • 0028901793 scopus 로고
    • Bee venom immunotherapy results in decrease in IL-4 and IL-5 and increase of IFN-γ secretion in specific allergen-stimulated T cell cultures
    • Jutel M, Pichler WJ, Skrbic D, Urwyler A, Dahinden C, Muller UR. Bee venom immunotherapy results in decrease in IL-4 and IL-5 and increase of IFN-γ secretion in specific allergen-stimulated T cell cultures. J Immunol 1995; 154:4187-94.
    • (1995) J Immunol , vol.154 , pp. 4187-4194
    • Jutel, M.1    Pichler, W.J.2    Skrbic, D.3    Urwyler, A.4    Dahinden, C.5    Muller, U.R.6
  • 23
    • 0030956363 scopus 로고    scopus 로고
    • Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects
    • Bellinghausen I, Metz G, Enk AH, Christmann S, Knop J, Saloga J. Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects. Eur J Immunol 1997; 27:1131-9.
    • (1997) Eur J Immunol , vol.27 , pp. 1131-1139
    • Bellinghausen, I.1    Metz, G.2    Enk, A.H.3    Christmann, S.4    Knop, J.5    Saloga, J.6
  • 24
    • 0029820287 scopus 로고    scopus 로고
    • Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro
    • Akdis CA, Akdis M, Blesken T et al. Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J Clin Invest 1996; 98:1676-83.
    • (1996) J Clin Invest , vol.98 , pp. 1676-1683
    • Akdis, C.A.1    Akdis, M.2    Blesken, T.3
  • 25
    • 0030751917 scopus 로고    scopus 로고
    • Modulation of T cell response to phospholipase A2-derived peptides by conventional bee venom immunotherapy
    • Kammerer R, Chvatchko J, Kettner A, Dufour N, Corradin G, Spertini F. Modulation of T cell response to phospholipase A2-derived peptides by conventional bee venom immunotherapy. J Allergy Clin Immunol 1997; 100:96-103.
    • (1997) J Allergy Clin Immunol , vol.100 , pp. 96-103
    • Kammerer, R.1    Chvatchko, J.2    Kettner, A.3    Dufour, N.4    Corradin, G.5    Spertini, F.6
  • 26
    • 0031045733 scopus 로고    scopus 로고
    • The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells
    • Carballido JM, Faith A, Carballido-Perrig N, Blaser K. The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells. Eur J Immunol 1997; 27:515-21.
    • (1997) Eur J Immunol , vol.27 , pp. 515-521
    • Carballido, J.M.1    Faith, A.2    Carballido-Perrig, N.3    Blaser, K.4
  • 27
    • 0030704726 scopus 로고    scopus 로고
    • + T cell subset inhibits antigen-specific T cell responses and prevents colitis
    • + T cell subset inhibits antigen-specific T cell responses and prevents colitis. Nature 1997; 389:737-42.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 28
    • 0034327264 scopus 로고    scopus 로고
    • T regulatory cells 1 inhibit a Th2-specific response in vivo
    • Cottrez F, Hurst SD, Coffman RL, Groux H. T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol 2000; 165:4848-53.
    • (2000) J Immunol , vol.165 , pp. 4848-4853
    • Cottrez, F.1    Hurst, S.D.2    Coffman, R.L.3    Groux, H.4
  • 29
    • 0026094306 scopus 로고
    • Interleukin 10 inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174:1209-20.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    De Vries, J.E.5
  • 30
    • 0033813696 scopus 로고    scopus 로고
    • A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding
    • Akdis CA, Joss A, Akdis M, Faith A, Blaser K. A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding. FASEB J 2000; 14:1666-8.
    • (2000) FASEB J , vol.14 , pp. 1666-1668
    • Akdis, C.A.1    Joss, A.2    Akdis, M.3    Faith, A.4    Blaser, K.5
  • 31
    • 0031946481 scopus 로고    scopus 로고
    • Cyclosporin A increases interferon-gamma production by T cells when co-stimulated through CD28
    • Rafiq K, Kasran A, Peng X et al. Cyclosporin A increases interferon-gamma production by T cells when co-stimulated through CD28. Eur J Immunol 1998; 28:1481-91.
    • (1998) Eur J Immunol , vol.28 , pp. 1481-1491
    • Rafiq, K.1    Kasran, A.2    Peng, X.3
  • 32
    • 0033010046 scopus 로고    scopus 로고
    • Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients
    • Wierenga EA, Walchner M, Kick G, Kapsenberg ML, Weiss EH, Messer G. Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients. Int Immunol 1999; 11:297-306.
    • (1999) Int Immunol , vol.11 , pp. 297-306
    • Wierenga, E.A.1    Walchner, M.2    Kick, G.3    Kapsenberg, M.L.4    Weiss, E.H.5    Messer, G.6
  • 33
    • 0032483991 scopus 로고    scopus 로고
    • Involvement of jun and rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28
    • Li-Weber M, Giasi M, Krammer PH. Involvement of jun and rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28. J Biol Chem 1998; 273:32460-6.
    • (1998) J Biol Chem , vol.273 , pp. 32460-32466
    • Li-Weber, M.1    Giasi, M.2    Krammer, P.H.3
  • 34
    • 0034283018 scopus 로고    scopus 로고
    • Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun
    • Macian F, Garcia-Rodriguez C, Rao A. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J 2000; 19:4783-95.
    • (2000) EMBO J , vol.19 , pp. 4783-4795
    • Macian, F.1    Garcia-Rodriguez, C.2    Rao, A.3
  • 36
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism?
    • Schwartz RH. Models of T cell anergy: is there a common molecular mechanism? J Exp Med 1996; 184:1-8.
    • (1996) J Exp Med , vol.184 , pp. 1-8
    • Schwartz, R.H.1
  • 37
    • 0030239829 scopus 로고    scopus 로고
    • Defective transcription of the IL-2 gene is associated with impaired expression of c-fos, FosB and JunB in anergic helper 1 cells
    • Mondino A, Whaley CD, DeSilva DR, Li W, Jenkins MK, Mueller DL. Defective transcription of the IL-2 gene is associated with impaired expression of c-fos, FosB and JunB in anergic helper 1 cells. J Immunol 1996; 157:2048-57.
    • (1996) J Immunol , vol.157 , pp. 2048-2057
    • Mondino, A.1    Whaley, C.D.2    DeSilva, D.R.3    Li, W.4    Jenkins, M.K.5    Mueller, D.L.6


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