PEG10 is a c-MYC target gene in cancer cells

Cancer Research

Volumn 66, Issue 2, 2006, Pages 665-672

  Li, Chi Ming ^a   Margolin, Adam A ^a   Salas, Martha ^a   Memeo, Lorenzo ^a   Mansukhani, Mahesh ^a   Hibshoosh, Hanina ^a   Szabolcs, Matthias ^a   Klinakis, Apostolos ^a   Tycko, Benjamin ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CORRELATION ANALYSIS; E BOX ELEMENT; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTRON; LIVER CELL CARCINOMA; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; ONCOGENE C MYC; OPEN READING FRAME; PANCREAS CARCINOMA; PATERNALLY EXPRESSED GENE 10; PLACENTA; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTO ONCOGENE; SITE DIRECTED MUTAGENESIS; SYNCYTIOTROPHOBLAST; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; BREAST NEOPLASMS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, TRANSGENIC; PANCREATIC NEOPLASMS; PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; TUMOR CELLS, CULTURED;

EID: 31544474013     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1553     Document Type: Article

References (22)

1. Ono R, Kobayashi S, Wagatsuma H, et al. A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21. Genomics 2001;73:232-7.
2. Ono R, Shiura H, Aburatani H, Kohda T, Kaneko-Ishino T, Ishino F. Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Genome Res 2003;13:1696-705.
3. Smallwood A, Papageorghiou A, Nicolaides K, et al. Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta. Biol Reprod 2003;69:286-93.
4. Manktelow E, Shigemoto K, Brierley I. Characterization of the frameshift signal of Edr, a mammalian example of programmed -1 ribosomal frameshifting. Nucleic Acids Res 2005;33:1553-63.
5. Okabe H, Satoh S, Furukawa Y, et al. Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. Cancer Res 2003;63:3043-8.
6. Tsou AP, Chuang YC, Su JY, et al. Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers. J Biomed Sci 2003;10:625-35.
7. Zhang DY, Sabla G, Shivakumar P, et al. Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia. Hepatology 2004;39:954-62.
8. Lux A, Beil C, Majety M, et al. Human retroviral gag- and gag-pol-like proteins interact with the TGF-β receptor ALK1. J Biol Chem 2004;280:8482-93.
9. Hu CS, Xiong J, Zhang LJ, et al. PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia. Cell Mol Immunol 2004;1:280-94.
10. Grandori C, Cowley SM, James LP, Eisenman RN. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol 2000;16:653-99.
11. Fernandez PC, Frank SR, Wang L, et al. Genomic targets of the human c-Myc protein. Genes Dev 2003;17:1115-29.
12. Zeller KI, Jegga AG, Aronow BJ, O'Donnell KA, Dang CV. An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol 2003;4:R69.
13. Li CM, Guo M, Borczuk A, et al. Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. Am J Pathol 2002;160:2181-90.
14. Wu KJ, Polack A, Dalla-Favera R. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 1999;283:676-9.
15. Wu KJ, Grandori C, Amacker M, et al. Direct activation of TERT transcription by c-MYC. Nat Genet 1999;21:220-4.
16. Cardiff RD, Sinn E, Muller W, Leder P. Transgenic oncogene mice. Tumor phenotype predicts genotype. Am J Pathol 1991;139:495-501.
17. Wulf G, Garg P, Liou YC, Iglehart D, Lu KP. Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. EMBO J 2004;23:3397-407.
18. Aulmann S, Bentz M, Sinn HP. C-myc oncogene amplification in ductal carcinoma in situ of the breast. Breast Cancer Res Treat 2002;74:25-31.
19. Glockner S, Lehmann U, Wilke N, Kleeberger W, Langer F, Kreipe H. Amplification of growth regulatory genes in intraductal breast cancer is associated with higher nuclear grade but not with the progression to invasiveness. Lab Invest 2001;81:565-71.
20. Courjal F, Cuny M, Simony-Lafontaine J, et al. Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups. Cancer Res 1997;57:4360-7.
21. Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004;4:143-53.
22. Haig D. Genomic imprinting and kinship: how good is the evidence? Annu Rev Genet 2004;38:553-85.