Synergy among phytochemicals within crucifers: Does it translate into chemoprotection?

Journal of Nutrition

Volumn 135, Issue 12, 2005, Pages

  Wallig, Matthew A ^a   Heinz Taheny, Kathleen M ^a   Epps, Donna L ^a   Gossman, Tamara ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Aflatoxin B1; Chemoprotection; Crambene; Glutathione S transferase ; Indole 3 carbinol; Phytochemicals; Synergy

Indexed keywords

1 CYANO 2 HYDROXY 3 BUTENE; 3 INDOLEMETHANOL; AFLATOXIN B1; GLUCOSINOLATE; GLUTATHIONE TRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; BILE DUCT; CARCINOGENESIS; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CRUCIFERA; DETOXIFICATION; DIET SUPPLEMENTATION; ENZYME ACTIVITY; HYPERPLASIA; LIVER; LIVER TOXICITY; MALE; NONHUMAN; PHYTOCHEMISTRY; RAT; SCORING SYSTEM; TISSUE SECTION; VEGETABLE;

ANIMALIA; BRASSICACEAE;

EID: 31544470585     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/135.12.2972s     Document Type: Conference Paper

References (44)

1. Steinmetz KA, Potter JD. Vegetables, fruit and cancer. Cancer Cause Cont. 1991;2:325-57.
2. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomark Prev. 1996;5:733-48.
3. Keck AS, Finley JW. Cruciferous vegetables: Cancer protective mechanisms of glucosinolate hydrolysis products and selenium. Integr Cancer Ther. 2004;3(1):5-12.
4. Finley JW. Proposed criteria for assessing the efficacy of cancer reduction by plant foods enriched in carotenoids, glucosinolates, polyphenols and selenocompounds. Ann Bot (Lond). 2005;95(7):1075-96.
5. Wallig MA, Kingston S, Staack R, Jeffery EH. Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts. Food Chem Toxicol. 1998;36(5):365-73.
6. Staack R, Kingston S, Wallig MA, Jeffery EH. A comparison of the individual and collective effects of four glucosinolate breakdown products from Brussels sprouts on induction of detoxification enzymes. Toxicol Appl Pharmacol. 1998;149(1):17-23.
7. March TH, Jeffery EH, Wallig MA. The cruciferous nitrile, crambene, induces rat hepatic and pancreatic glutathione S-transferases. Toxicol Sci. 1998;442(4):82-90.
8. Kushad MM, Brown AF, Kurilich AC, Juvik JA, Klein BP, Wallig MA, Jeffery EH. Variation of glucosinolates in vegetable crops of Brassica oleracea. J Agric Food Chem. 1999;47(4):1541-8.
9. Fenwick GR, Heaney RK, Mullin WJ. Glucosinolates and their breakdown products in food and food plants. CRC Crit Rev Food Sci Nutr. 1983;18:123-201.
10. Kim YS, Milner JA. Targets for indole-3-carbinol in cancer prevention. J Nutr Biochem. 2005;16(2):65-73.
11. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. Ann NY Acad Sci. 1999;889:204-13.
12. Bailey GS, Dashwood RH, Fon AT, Williams DE, Scanlan RA, Hendricks JD. Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol quantitative analysis of inhibition versus promotion. In: O'Neil IK, Chen J, Bartsch H, editors. Relevance to human cancer of N-nitroso compounds, Lyon: International Agency for Research on Cancer; 1991. p. 275-80.
13. Johnson F, Huff J. Development of a multi-organ rat model for evaluation of chemopreventive agents: efficacy of indole-3-carbinol - certain health supplements may cause both carcinogenic and anticarcinogenic effects. Carcinogenesis. 2002;23(10):1767-8.
14. Wallig MA, Jeffery EH. Enhancement of pancreatic and hepatic glutathione levels in rats during cyanohydroxybutene intoxication. Fund Appl Toxicol. 1990;14:144-59.
15. Wallig MA, Kore AM, Crawshaw J, Jeffery EH. Separation of the toxic and glutathione-enhancing effects of the naturally occurring nitrile, cyanohydroxybutene. Fund Appl Toxicol. 1992;19:598-606.
16. Nho CW, Jeffery EH. Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol. Toxicol Appl Pharmacol. 2004;198(1):40-8.
17. Nguyen T, Sheratt PJ, Pickett CB. Regulatory mechanism controlling gene expression mediated by the antioxidant response element. Ann Rev Pharmacol Toxicol. 2003;43:233-60.
18. Nho CW, Jeffery EH. The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables. Toxicol Appl Pharmacol. 2001;174:146-52.
19. Liu RH. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. J Nutr. 2004;134:3479S-85.
20. Horvath PM, Ip C. Synergistic effect of vitamin E and selenium in the chemoprevention of mammary carcinogenesis in rats. Cancer Res. 1983;43(11):5335-41.
21. Curphey TJ, Kulhmann ET, Roebuck BB, Longnecker DS. Inhibition of pancreatic and liver carcinogenesis in rats by retinoid- and selenium-supplemented diets. Pancreas. 1988;3(1):36-40.
22. Shklar B, Schwartz J, Trickler D, Cherverie SR. The effect of a mixture of beta-carotene, alpha-tocopherol, glutathione and ascorbic acid for cancer prevention. Nutr Cancer. 1983;20(2):145-51.
23. Zhou JR, You L, Zhong Y, Blackburn GL. Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice. J Nutr. 2003;133(2):516-21.
24. 1-induced carcinogenesis by indole-3-carbinaol in rat liver - predicting the outcome using early biomarkers. Carcinogenesis. 1998;19(10):1829-36.
25. 1 biotransformation in rat liver: Implications for human chemointervention. Cancer Res. 1996;56(10):2306-13.
26. Kim DJD, Lee KK, Han BS, Ahn B, Bae JH, Jang JJ. Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione-S-transferase placental form-positive liver-cell foci in Sprague-Dawley rats. Jpn J Cancer Res. 1994;85:578-83.
27. Niedoborski T, Klein BP, Wallig MA. Rapid isolation and purification of 1-cyano-2-hydroxy-3-butene (crambene) from Crambe abyssinica seed meal using immiscible solvent extraction and high-performance liquid chromatography. J Agric Food Chem. 2001;49(8):3594-9.
28. American Institute of Nutrition. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
29. Steele RGD, Torrie JH. Principles and procedures of statistics: a biometrical approach. 2nd ed. New York: McGraw-Hill; 1980.
30. March TH, Jeffery EH, Wallig MA. Characterization of rat pancreatic glutathione S-transferases by chromatofocusing, reverse phase HPLC and immunohistochemistry. Pancreas. 1998;17(3):217-28.
31. Image J [homepage on the Internet]. Bethesda (MD): Research Services Branch, National Institute of Mental Health [cited 2005 Aug 16]. Available from: http://rsb.info.nih.gov/ij/.
32. Lhoste ER, Roebuck BD, Brinck-Johnson T, Longenecker DS. Effect of castration and hormone replacement on azaserine-induced pancreatic carcinogenesis in male and female Fischer rats. Carcinogenesis. 1987;8:699-703.
33. Keck AS, Staack R, Jeffery EH. The cruciferous nitrile crambene has bioactivity similar to sulforaphane when administered to Fischer 344 rats but is far less potent in cell culture. Nutr Cancer. 2002;42(2):233-40.
34. Reichelt M, Brown PD, Schneider B, Oldham NJ, Stauber E, Tokuhisa J, Kliebenstein DJ, Mitchell-Olds, T, Gershenzon J. Benzoic acid glucosinolate esters and other glucosinolates from Arabidopsis thaliana. Phytochemistry. 2002;59:663-71.
35. Brown AF, Yousef GG, Jeffery EH, Klein BP, Kushad MM, Wallig MA, Juvik JA. Glucosinolate profiles in broccoli (Brassica oleracea L.): stability over environments and implications for cancer chemoprotection. J Hort Sci. 2002;127:807-13.
36. Wattenberg LW. Inhibition of chemical carcinogenesis. J Natl Cancer Inst. 1978;60(1):11-8.
37. Jarrell VL, Epps D, Wallig MA, Jeffery EH. Antiproliferative effects of crambene, a nitrile common in cruciferous vegetables [abstract]. FASEB J. 1999;13(5):A918.
38. Guo Z, Smith TJ, Wang E, Sadrieh N, Ma Q, Thomas PE, Yang CS. Effects of phenylethylisothiocyanate, a carcinogenesis inhibitor, on xenobiotic- metabolizing enzymes and nitrosamine metabolism in rats. Carcinogenesis. 1992;13:2205-10.
39. Kelley MK, Bjeldanes LF. Modulation of glutathione S-transferase activity and isozyme pattern in liver and small intestine of rats fed goitrin- and T3-supplemented diets. Food Chem Toxicol. 1995;33(2):129-37.
40. Kensler TW, Groopman JD, Eaton DL, Curphey TJ, Roebuck BD. Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione. Carcinogenesis. 1992;13(1):95-100.
41. Chu Y-F, Sun J, Wu X, Liu RH. Antioxidants and antiproliferative activities of vegetables. J Agric Food Chem. 2002;50:6910-6.
42. Banuelos GS. Irrigation of broccoli and canola with boron- and seleniumladen effluent. J Environ Qual. 2002;31(6):1802-8.
43. Finley JW, Keck AS, Robbins RJ, Hintze KJ. Selenium enrichment of broccoli: Interaction between selenium and secondary plant compounds. J Nutr. 2005;135:1236-8.
44. Wallig MA, Kuchan MJ, Milner JA. Differential effects of cyanohydroxybutene and selenium on normal and neoplastic canine mammary cells in vitro. Toxicol Lett. 1993;69:97-105.