Outer surface lipoproteins of Borrelia burgdorferi vary in their ability to induce experimental joint injury

Arthritis and Rheumatism

Volumn 50, Issue 7, 2004, Pages 2360-2369

  Batsford, Stephen ^a   Dunn, John ^b   Mihatsch, Michael ^c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPEPTIDE; LIPOPROTEIN; OUTER MEMBRANE PROTEIN; OUTER SURFACE PROTEIN; PALMITOYL 3 CYSTEINYLSERYLLYSINE; RECOMBINANT OSPA; RECOMBINANT OSPB; RECOMBINANT OSPC; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ALLERGIC ARTHRITIS; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BORRELIA BURGDORFERI; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG POTENCY; EXPERIMENTAL INFECTION; JOINT INJURY; LIPID METABOLISM; LIPOPROTEIN METABOLISM; LYME DISEASE; NONHUMAN; PATHOGENESIS; PEPTIDE ANALYSIS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BACTERIAL OUTER MEMBRANE PROTEINS; BORRELIA BURGDORFERI; JOINTS; LIPOPOLYSACCHARIDES; LIPOPROTEINS; LYME DISEASE; MALE; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR;

EID: 3142707956     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.20337     Document Type: Article

References (52)

1. Vasselon T, Detmers PA. Toll receptors: a central element in innate immune responses. Infect Immun 2002;70:1033-41.
2. Melchers F, Braun V, Galanos C. The lipoprotein of the outer membrane of Escherichia coli: a B-lymphocyte mitogen. J Exp Med 1975;142:473-82.
3. Reitermann A, Metzger J, Wiesmuller KH, Jung G, Bessler WG. Lipopeptide derivatives of bacterial lipoprotein constitute potent immune adjuvants combined with or covalently coupled to antigen or hapten. Biol Chem Hoppe Seyler 1989;370:343-52.
4. Muhlradt PF, Kiess M, Meyer H, Sussmuth R, Jung G. Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J Exp Med 1997;185:1951-8.
5. Ma Y, Weis JJ. Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties. Infect Immun 1993;61:3843-53.
6. Wooten RM, Modur VR, McIntyre TM, Weis JJ. Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-κ B and inflammatory activation in human endothelial cells. J Immunol 1996;157:4584-90.
7. Knigge H, Simon MM, Meuer SC, Kramer MD, Wallich R. The outer surface lipoprotein OspA of Borrelia burgdorferi provides co-stimulatory signals to normal human peripheral CD4+ and CD8+ T lymphocytes. Eur J Immunol 1996;26:2299-303.
8. Morrison TB, Weis JH, Weis JJ. Borrelia burgdorferi outer surface protein A (OspA) activates and primes human neutrophils. J Immunol 1997;158:4838-45.
9. Morr M, Takeuchi O, Akira S, Simon MM, Muhlradt PF. Differential recognition of structural details of bacterial lipopeptides by toll-like receptors. Eur J Immunol 2002;32:3337-47.
10. Akira S. Mammalian Toll-like receptors. Curr Opin Immunol 2003;15:5-11.
11. Hirschfeld M, Kirschning CJ, Schwandner R, Wesche H, Weis JH, Wooten RM, et al. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol 1999;163:2382-6.
12. Norgard MV, Riley BS, Richardson JA, Radolf JD. Dermal inflammation elicited by synthetic analogs of Treponema pallidum and Borrelia burgdorferi lipoproteins. Infect Immun 1995;63:1507-15.
13. Gondolf KB, Mihatsch M, Curschellas E, Dunn JJ, Batsford SR. Induction of experimental allergic arthritis with outer surface proteins of Borrelia burgdorferi. Arthritis Rheum 1994;37:1070-7.
14. Brackertz D, Mitchell GF, Mackay IR. Antigen-induced arthritis in mice: I. Induction of arthritis in various strains of mice. Arthritis Rheum 1977;20:841-50.
15. Dunn JJ, Lade BN, Barbour AG. Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: high level expression and purification of a soluble recombinant form of OspA. Protein Expr Purif 1990;1:159-68.
16. Rauer S, Kayser M, Neubert U, Rasiah C, Vogt A. Establishment of enzyme-linked immunosorbent assay using purified recombinant 83-kilodalton antigen of Borrelia burgdorferi sensu stricto and Borrelia afzelii for serodiagnosis of Lyme disease. J Clin Microbiol 1995;33:2596-600.
17. Dutton A, Adams M, Singer SJ. Bifunctional imidoesters as cross-linking reagents. Biochem Biophys Res Commun 1966;23:730-9.
18. Ludwig ML HM. Amidation. In: CHW Hirs, editor. Methods in enzymology. Orlando (FL): Academic Press; 1967. p. 595.
19. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
20. Gondolf KB, Batsford SR, Lassle G, Curschellas E, Mertz A. Handling of cationic antigens in the joint and induction of chronic allergic arthritis. Virchows Arch B Cell Pathol 1991;60:353-63.
21. McConahey PJ, Dixon FJ. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol 1966;29:185-9.
22. Van Lent PL, Dekker C, Mosterd J, van den Bersselaar L, van den Berg WB. Allergic arthritis induced by cationic proteins: role of molecular weight. Immunology 1989;67:447-52.
23. Ramesh G, Alvarez AL, Roberts ED, Dennis VA, Lasater BL, Alverez X, et al. Pathogenesis of Lyme neuroborreliosis: Borrelia burgdorferi lipoproteins induce both proliferation and apoptosis in rhesus monkey astrocytes. Eur J Immunol 2003;33:2539-50.
24. Van den Berg WB, van de Putte LB, Zwarts WA, Joosten LA. Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. J Clin Invest 1984;74:1850-9.
25. Mertz AK, Batsford SR, Curschellas E, Kist MJ, Gondolf KB. Cationic Yersinia antigen-induced chronic allergic arthritis in rats: a model for reactive arthritis in humans. J Clin Invest 1991;88:632-42.
26. Gondolf KB, Batsford SR, Vogt A. Isolation of an outer membrane protein complex from Borrelia burgdorferi by n-butanol extraction and high-performance ion-exchange chromatography. J Chromatogr 1990;521:325-34.
27. Ebnet K, Brown KD, Siebenlist UK, Simon MM, Shaw S. Borrelia burgdorferi activates nuclear factor-κ B and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts. J Immunol 1997;158:3285-92.
28. Porcella SF, Schwan TG. Borrelia burgdorferi and Treponema pallidum: a comparison of functional genomics, environmental adaptations, and pathogenic mechanisms. J Clin Invest 2001;107:651-6.
29. Liang FT, Nelson FK, Fikrig E. Molecular adaptation of Borrelia burgdorferi in the murine host. J Exp Med 2002;196:275-80.
30. Hodzic E, Feng S, Freet KJ, Borjesson DL, Barthold SW. Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface. Infect Immun 2002;70:3382-8.
31. Fingerle V, Hauser U, Liegl G, Petko B, Preac-Mursic V, Wilske B. Expression of outer surface proteins A and C of Borrelia burgdorferi in Ixodes ricinus. J Clin Microbiol 1995;33:1867-9.
32. Schwan TG, Piesman J. Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J Clin Microbiol 2000;38:382-8.
33. Leuba-Garcia S, Martinez R, Gern L. Expression of outer surface proteins A and C of Borrelia afzelii in lxodes ricinus ticks and in the skin of mice. Zentralbl Bakteriol 1998;287:475-84.
34. Schwan TG, Piesman J, Golde WT, Dolan MC, Rosa PA. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci U S A 1995;92:2909-13.
35. Fung BP, McHugh GL, Leong JM, Steere AC. Humoral immune response to outer surface protein C of Borrelia burgdorferi in Lyme disease: role of the immunoglobulin M response in the serodiagnosis of early infection. Infect Immun 1994;62:3213-21.
36. Wilske B, Fingerle V, Herzer P, Hofmann A, Lehnert G, Peters H, et al. Recombinant immunoblot in the serodiagnosis of Lyme borreliosis: comparison with indirect immunofluorescence and enzyme-linked immunosorbent assay. Med Microbiol Immunol (Berl) 1993;182:255-70.
37. Batsford S, Rust C, Neubert U. Analysis of antibody response to the outer surface protein family in lyme borreliosis patients. J Infect Dis 1998;178:1676-83.
38. Lengl-Janssen B, Strauss AF, Steere AC, Kamradt T. The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis. J Exp Med 1994;180:2069-78.
39. Vaz A, Glickstein L, Field JA, McHugh G, Sikand VK, Damle N, et al. Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme disease. Infect Immun 2001;69:7437-44.
40. Kalish RA, Leong JM, Steere AC. Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect Immun 1993;61:2774-9.
41. Croke CL, Munson EL, Lovrich SD, Christopherson JA, Remington MC, England DM, et al. Occurrence of severe destructive lyme arthritis in hamsters vaccinated with outer surface protein A and challenged with Borrelia burgdorferi. Infect Immun 2000;68:658-63.
42. Wormser GP. Prospects for a vaccine to prevent Lyme disease in humans. Clin Infect Dis 1995;21:1267-74.
43. Chu HJ, Chavez LG Jr, Blumer BM, Sebring RW, Wasmoen TL, Acree WM. Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin. J Am Vet Med Assoc 1992;201:403-11.
44. Fikrig E, Tao H, Chen M, Barthold SW, Flavell RA. Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. J Clin Invest 1995;96:1706-14.
45. Nocton JJ, Dressler F, Rutledge BJ, Rys PN, Persing DH, Steere AC. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med 1994;330:229-34.
46. Persing DH, Rutledge BJ, Rys PN, Podzorski DS, Mitchell PD, Reed KD, et al. Target imbalance: disparity of Borrelia burgdorferi genetic material in synovial fluid from Lyme arthritis patients. J Infect Dis 1994;169:668-72.
47. Gross DM, Forsthuber T, Tary-Lehmann M, Etling C, Ito K, Nagy ZA, et al. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 1998;281:703-6.
48. Benoist C, Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat Immunol 2001;2:797-801.
49. Gomes-Solecki MJ, Wormser GP, Dattwyler RJ. IFNγ production in peripheral blood of early Lyme disease patients to hLFAαL (aa326-345). BMC Musculoskelet Disord 2002;3:25-37.
50. Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig E, Schoen RT, et al, and the Lyme Disease Vaccine Study Group. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. N Engl J Med 1998;339:209-15.
51. Sigal LH, Zahradnik JM, Lavin P, Patella SJ, Bryant G, Haselby R, et al, and the Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium. A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. N Engl J Med 1998;339:216-22.
52. Bockenstedt LK, Hodzic E, Feng S, Bourrel KW, de Silva A, Montgomery RR, et al. Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infect Immun 1997;65:4661-7.