Occurrence of severe destructive lyme arthritis in hamsters vaccinated with outer surface protein A and challenged with Borrelia burgdorferi

Infection and Immunity

Volumn 68, Issue 2, 2000, Pages 658-663

  Croke, Cindy L ^a,b   Munson, Erik L ^a,b   Lovrich, Steven D ^d   Christopherson, John A ^a,b   Remington, Monica C ^a,b   England, Douglas M ^b,c   Callister, Steven M ^d   Schell, Ronald F ^a,b  

^a WISCONSIN STATE LABORATORY OF HYGIENE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c MERITER HOSPITAL   (United States)

^d GUNDERSEN LUTHERAN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM HYDROXIDE; EPITOPE; OUTER SURFACE PROTEIN A; RECOMBINANT VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BORRELIA BURGDORFERI; CONTROLLED STUDY; DRUG SAFETY; GENE AMPLIFICATION; HAMSTER; HISTOPATHOLOGY; IMMUNIZATION; INOCULATION; LYME DISEASE; MOLECULAR CLONING; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; VACCINE PRODUCTION;

ANIMALS; ANTIGENS, SURFACE; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; CRICETINAE; LIPOPROTEINS; LYME DISEASE; VACCINATION; VACCINES, SYNTHETIC;

EID: 0033958918     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.2.658-663.2000     Document Type: Article

References (33)

1. Akin, E., G. L. McHugh, R. A. Flavell, E. Fikrig, and A. C. Steere. 1999. The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. Infect. Immun. 67:173-181.
2. Appel, M. J., S. Allan, R. H. Jacobson, T. L. Lauderdale, Y. F. Chang, S. J. Shin, J. W. Thomford, R. J. Todhunter, and B. A. Summers. 1993. Experimental Lyme disease in dogs produces arthritis and persistent infection. J. Infect. Dis. 167:651-664.
3. Aydintug, M. K., Y. Gu, and M. T. Philipp. 1994. Borrelia burgdorferi antigens that are targeted by antibody-dependent, complement-mediated killing in the rhesus monkey. Infect. Immun. 62:4929-4937.
4. Barthold, S. W., D. S. Beck, G. M. Hansen, G. A. Terwilliger, and K. D. Moody. 1990. Lyme borreliosis in selected strains and ages of laboratory mice. J. Infect. Dis. 162:133-138.
5. Barthold, S. W., K. D. Moody, G. A. Terwilliger, R. O. Jacoby, and A. C. Steere. 1988. An animal model for Lyme arthritis. Ann. N. Y. Acad. Sci. 539:264-273.
6. Callister, S. M., K. L. Case, W. A. Agger, R. F. Schell, R. C. Johnson, and J. L. E. Ellingson. 1990. Effects of bovine serum albumin on the ability of Barbour-Stoenner-Kelly medium to detect Borrelia burgdorferi. J. Clin. Microbiol. 28:363-365.
7. Centers for Disease Control and Prevention. 1997. Lyme disease - United States, 1996. Morbid. Mortal. Weekly Rep. 45:1132-1136.
8. Du Chateau, B. K., E. L. Munson, D. M. England, S. D. Lovrich, S. M. Callister, J. R. Jensen, and R. F. Schell. 1999. Macrophages interact with enriched populations of distinct T lymphocyte subsets for the induction of severe destructive Lyme arthritis. J. Leukoc. Biol. 65:162-170.
9. Fikrig, E., S. W. Barthold, N. Marcantonio, K. Deponte, F. S. Kantor, and R. A. Flavell. 1992. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect. Immun. 60:657-661.
10. Gasser, R., S. Horn, E. Reisinger, L. Fisher, R. Pokan, I. Wendelin, and W. Klein. 1998. First description or recurrent pericardial effusion associated with Borrelia burgdorferi infection. Int. J. Cardiol. 64:309-310.
11. Gilmore, R. D., Jr., K. J. Kappel, M. C. Dolan, T. R. Burkot, and B. J. B. Johnson. 1996. Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC. Infect. Immun. 64:2234-2239.
12. Gross, D. M., T. Forsthuber, M. Tary-Lehmann, C. Etling, K. Ito, Z. A. Nagy, J. A. Field, A. C. Steere, and B. Huber. 1998. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 281: 703-706.
13. Hejka, A., J. L. Schmitz, D. M. England, S. M. Callister, and R. F. Schell. 1989. Histopathology of Lyme arthritis in LSH hamsters. Am. J. Pathol. 134:1113-1123.
14. Kalish, R. A., J. M. Leong, and A. C. Steere. 1993. Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect. Immun. 61:2774-2779.
15. Keane-Myers, A., and S. P. Nickell. 1995. T cell subset-dependent modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 154:1770-1776.
16. Keane-Myers, A., and S. P. Nickell. 1995. Role of IL-4 and IFN-γ in modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 155:2020-2028.
17. Keller, D., F. T. Koster, D. H. Marks, P. Hosbach, L. F. Erdile, and J. P. Mays. 1994. Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine. JAMA 271:1764-1768.
18. Lim, L. C. L., D. M. England, B. K. DuChateau, N. J. Glowacki, J. R. Creson, S. D. Lovrich, S. M. Callister, D. A. Jobe, and R. F. Schell. 1994. Development of destructive arthritis in vaccinated hamsters challenged with Borrelia burgdorferi. Infect. Immun. 62:2825-2833.
19. + T lymphocytes in induction of severe destructive Lyme arthritis in inbred LSH hamsters. Infect. Immun. 63:4818-4825.
20. Lovrich, S. D., S. M. Callister, B. K. DuChateau, L. C. L. Lim, J. Winfrey, S. P. Day, and R. F. Schell. 1995. Abilities of OspA proteins from different seroprotective groups of Borrelia burgdorferi to protect hamsters from infection. Infect. Immun. 63:2113-2119.
21. Matyniak, J. E., and S. L. Reiner. 1995. T helper phenotype and genetic susceptibility in experimental Lyme disease. J. Exp. Med. 181:1251-1254.
22. Padilla, M. L., S. M. Callister, R. F. Schell, G. L. Bryant, D. A. Jobe, S. D. Lovrich, B. K. Du Chateau, and J. R. Jensen. 1996. Characterization of the protective borreliacidal antibody response in humans and hamsters after vaccination with a Borrelia burgdorferi outer surface protein A vaccine. J. Infect. Dis. 174:739-746.
23. Probert, W. S., M. Crawford, R. B. Cadiz, and R. B. Le Febvre. 1997. Immunization with outer surface protein (Osp) A, but not OspC, provides cross-protection of mice challenged with North American isolates of Borrelia burgdorferi. J. Infect. Dis. 175:400-405.
24. Probert, W. S., and R. B. LeFebvre. 1994. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infect. Immun. 62:1920-1926.
25. Schaible, U. E., M. D. Kramer, R. Wallich, T. Tran, and M. M. Simon. 1991. Experimental Borrelia burgdorferi infection in inbred mouse strains: antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis. Eur. J. Immunol. 21:2397-2405.
26. Schmitz, J. L., R. F. Schell, A. Hejka, D. M. England, and L. Konick, 1988. Induction of Lyme arthritis in LSH hamsters. Infect. Immun. 56:2336-2342.
27. Scriba, M., J. S. Ebrahin, T. Schlott, and H. Eiffert. 1993. The 39-kilodalton protein of Borrelia burgdorferi: a target for bactericidal human monoclonal antibodies. Infect. Immun. 61:4523-4526.
28. Sigal, L. H., and S. Williams. 1997. A monoclonal antibody to Borrelia burgdorferi flagellin modifies neuroblastoma cell neuritogenesis in vitro: a possible role for autoimmunity in the neuropathy of Lyme disease. Infect. Immun. 65:1722-1728.
29. Sigal, L. H., J. M. Zahradnik, P. Lavin, S. J. Patella, G. Bryant, R. Haselby, E. Hilton, M. Kunkel, D. Adler-Klein, T. Doherty, J. Evans, and S. Malawista. 1998. A vaccine consisting of recombinant Borrelia burgdorferi outer surface protein A to prevent Lyme disease. N. Engl. J. Med. 339:216-222.
30. Steere, A. C., V. Sikand, F. Meurice, D. L. Parenti, E. Fikrig, R. T. Schoen, J. Nowakowski, C. H. Schmid, S. Laukamp, C. Buscarino, and D. S. Krause. 1998. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer surface lipoprotein A with adjuvant. N. Engl. J. Med. 339:209-215.
31. Steere, A. C., R. T. Schoen, and E. Taylor. 1987. The clinical evolution of Lyme arthritis. Ann. Intern. Med. 107:725-731.
32. Steere, A. C., A. Grbofsky, M. E. Patarroyo, R. J. Winchester, J. A. Hardin, and S. E. Malawista. 1979. Chronic Lyme arthritis: clinical and immunogenetic differentiation from rheumatoid arthritis. Ann. Intern. Med. 90:896-901.
33. Tai, K.-F., Y. Ma, and J. J. Weis. 1994. Normal human B lymphocytes and mononuclear cells respond to the mitogenic and cytokine-stimulatory activities of Borrelia burgdorferi and its lipoprotein OspA. Infect. Immun. 62:520-528.