Strategies for finding new pharmacological targets for neuropathic pain

Current Pain and Headache Reports

Volumn 8, Issue 3, 2004, Pages 187-191

  Devor, Marshal ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANALGESIC AGENT; CAPSAICIN; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CHANNEL; SODIUM ION; TETRODOTOXIN;

ALLODYNIA; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL MODEL; ANTINOCICEPTION; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; DISEASE CONTROL; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG TARGETING; HUMAN; MEDICAL DECISION MAKING; NEUROPATHIC PAIN; NOCICEPTION; NOCICEPTIVE RECEPTOR; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; REVIEW; SPINAL CORD NERVE CELL; SPINAL GANGLION; TREATMENT PLANNING;

EID: 3142683027     PISSN: 15313433     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11916-004-0050-8     Document Type: Review

References (21)

1. Ruda MA, Ling QD, Hohmann AG, et al.: Altered nociceptive neuronal circuits after neonatal peripheral inflammation. Science 2000, 289:628-631.
2. Devor M: Pain and "state" induced analgesia: an introduction. In Mechanisms of Stress-Induced Analgesia. Edited by Curzon G, Trickebank MD. Sussex: Wiley; 1984:1-18.
3. Jordt SE, Julius D: Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 2002,108:421-430.
4. Froy O, Gurevitz M: Membrane potential modulators: a thread of scarlet from plants to humans. FASEB J 1998, 12:1793-1796.
5. Devor M: Neuropathic pain: What do we do with all these theories ? Acta Anesthesiologica Scandinavica 2001, 45:1121-1127.
6. Hokfelt T, Zhang X, Xu ZQ, et al.: Phenotype regulation in dorsal root ganglion neurons after nerve injury: focus on peptides and their receptors. In Molecular Neurobiology of Pain. Edited by Borsook D. Seattle: IASP Press; 1997:115-143.
7. Costigan M, Befort K, Karchewski L, et al.: Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci 2002, 3:16-28.
8. Xiao HS, Huang QH, Zhang FX, et al.: Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci U S A 2002, 99:8360-8365.
9. Tachibana T, Noguchi K, Ruda MA: Analysis of gene expression following spinal cord injury in rat using complementary DNA microarray. Neurosci Lett 2002, 327:133-137.
10. Ji RR, Kohno T, Moore KA, Woolf CJ: Central sensitization and LTP: Do pain and memory share similar mechanisms? Trends Neurosci 2003, 26:696-705.
11. Devor M, Seltzer Z: Pathophysiology of damaged nerves in relation to chronic pain. In Textbook of Pain, edn 4. Edited by Wall PD, Melzack R. London: Churchill Livingstone; 1999:129-164.
12. Amir R, Michaelis M, Devor M: Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and in neuropathic pain. J Neurosci 1999, 19:8589-8596.
13. Amir R, Liu CN, Kocsis JD: Oscillatory mechanism in primary sensory neurons. Brain 2002, 125:421-435.
14. Chung JM, Dib-Hajj SD, Lawson SN: 2003 Sodium channel subtypes and neuropathic pain. In Proceedings of the 10th World Congress on Pain: Progress in Pain Research and Management, vol 24. Edited by Dostrovsky JO, Carr DB, Koltzenburg M. Seattle: IASP Press; 2003:99-114.
15. Waxman SG: 2002, Sodium Channels and Neuronal Hyperexcitability, vol 241. London: Novartis Foundation; 2002.
16. Liu CN, Wall PD, Ben-Dor E, et al.: Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain 2000, 85:503-521.
17. Lyu YS, Park SK, Chung K, Chung JM: Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model. Brain Res 2000, 871:98-103.
18. v1.8 in NGF-induced hyperalgesia, but not neuropathic pain. Neuroreport 2001, 12:3077-3080.
19. Okuse K, Chaplin R, McMahon SB, et al.: Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain. Mol Cell Neurosci 1997, 10:196-207.
20. v1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol 2003, 550:921-926.
21. Devor M, Raber P: Heritability of symptoms in an animal model of neuropathic pain. Pain 1990, 42:51-67.