A Simple and efficient route to chaetomellic anhydride A: A potent natural ras farnesyl-protein transferase inhibitor

Synthesis

Volumn , Issue 10, 2004, Pages 1680-1686

  De Buyck, Laurent ^a   Cagnoli, Rita ^b   Ghelfi, Franco ^b   Merighi, Giulia ^b   Mucci, Adele ^b   Pagnoni, Ugo M ^b   Parsons, Andrew F ^c  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Amides; Cyclisations; Halogenation; Pyrrolidinones; Radical reactions

Indexed keywords

ENZYME INHIBITION; PROTEINS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

ATOM TRANSFER; CYCLIZATION;

NITROGEN COMPOUNDS;

2,2 DICHLOROPALMITIC ACID; AMIDE; ANTINEOPLASTIC AGENT; CHAETOMELLIC ANHYDRIDE A; CHLORINE DERIVATIVE; PALMITIC ACID DERIVATIVE; PYRROLIDINE DERIVATIVE; RAS PROTEIN; TRANSFERASE INHIBITOR; TRICHLOROPYRROLIDIN 2 ONE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 3142661868     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-829116     Document Type: Article

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