Hydro-de-halogenation and consecutive deprotection of chlorinated N-amido-pyrrolidin-2-ones with Raney-Ni: An effective approach to gabapentin

Tetrahedron

Volumn 59, Issue 50, 2003, Pages 9951-9960

  Cagnoli, Rita ^a   Ghelfi, Franco ^a   Pagnoni, Ugo M ^a   Parsons, Andrew F ^b   Schenetti, Luisa ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Cyclizations; Hydrazides; Hydrogenolysis; Pyrrolidinones

Indexed keywords

GABAPENTIN; N (1 PIPERAZINYL) 3,3 DICHLORO 4 (1 CHLOROBUTYL) 2 PYRROLIDINONE; N (4 MORPHOLINYL) 3,3 DICHLORO 4 (1 CHLOROBUTYL) 2 PYRROLIDINONE; N (ACETYLAMINO) 3,3 DICHLORO 4 (1 CHLOROBUTYL) 2 PYRROLIDINONE; N (BENZOYLAMINO) 3,3 DICHLORO 4 (1 CHLOROBUTYL) 2 PYRROLIDINONE; N (BENZOYLMETHYLAMINO) 3,3 DICHLORO 4 (1 CHLOROBUTYL) 2 PYRROLIDINONE; N (DIMETHYLAMINO) 3,3 DICHLORO 4 (1 CHLOROBUTYL) 2 PYRROLIDINE; N (PHTHALIMIDO) 3,3 DICHLORO 4 (1 CHLOROBUTYL) 2 PYRROLIDINONE; NICKEL; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHLORINATION; CYCLIZATION; DEPROTECTION REACTION; HALOGENATION; PRIORITY JOURNAL; SUBSTITUTION REACTION;

EID: 0242720249     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2003.10.046     Document Type: Article

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