Morphological analysis of hair follicles in alopecia areata

Microscopy Research and Technique

Volumn 38, Issue 4, 1997, Pages 443-451

  Tobin, Desmond J ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Cell death; Electron microscopy; Exclamation mark hair; Hair loss; Hair bulb; Melanocyte

Indexed keywords

ELECTRON MICROSCOPY; ELECTRONS; MORPHOLOGY; TISSUE;

CELL DEGENERATION; EXCLAMATION MARK HAIR; HAIR FOLLICLES; HAIR GROWTH; HAIR LOSS; HAIR- BULB; KERATINOCYTES; MELANOCYTE; MICROSCOPIC LEVELS; MORPHOLOGICAL ANALYSIS;

CELL DEATH;

ADOLESCENT; ADULT; ALOPECIA AREATA; ARTICLE; CELL DEGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; HAIR FOLLICLE; HAIR ROOT; HISTOLOGY; HUMAN; HUMAN TISSUE; MELANOCYTE; PRIORITY JOURNAL; ULTRASTRUCTURE;

EID: 0030764034     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0029(19970815)38:4<443::AID-JEMT12>3.0.CO;2-J     Document Type: Article

References (22)

1. Bystryn, J.-C., and Tamesis, J. (1991) Immunologic aspects of hair loss. J Invest Dermatol. 96:88S-89S.
2. Bystryn, J.-C., and Tobin, D.J. (1994) Alopecia areata is associated with antibodies to hair follicle melanocytes. J Invest Dermatol. 102:532.
3. Gollnick, H., and Orfanos, C.E. (1990) Alopecia areata. In: Hair and Hair diseases. C.E. Orfanos, and R. Happle, eds. Springer-Verlag, Berlin, pp 529-569.
4. Goos, M. (1971) Zur histopathologie der alopecia areata. Arch Derm Forsch. 240:160-172.
5. Harikawa, T., Norris, D.A., Johnson, T.W., Zekman, T., Dunscomb, N., Bennion, S.D., Jackson, R.L., Morelli, J.G. (1996) Dopa-negative melanocytes in the outer root sheath of human hair follicles express premelanosomal antigens but not melanosomal antigens or the melanosome-associated glycoprotein tyrosinase, TRP-1, and TRP-2. J Invest Dermatol 106:28-35.
6. Harmon, B.V. (1987) An ultrastructural study of spontaneous cell death in a mouse mastocytoma with particular reference to dark cells. J. Pathol., 153:345-355.
7. Johannisson, E. (1968) The fetal adrenal cortex in the human. Its ultrastructure at different stages of development and in different functional states. Acta Endocrinol., 58:7-107.
8. Karnovsky, M.J. (1965) Formaldenyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J. Cell Biol., 27:137a-138a.
9. Messenger, A.G., Slater, D.N., and Bleehen, S.S. (1986) Alopecia areata: Alterations in the hair growth cycle and correlation with follicular pathology. Br. J. Dermatol., 114:337-347.
10. Nutbrown, M., Hull, S.P., Cunliffe, W.J., Randall, V.A. (1995) Abnormalities in the ultrastructure of melanocytes and the outer root sheath of clinically normal hair follicles from alopecia areata scalps. J. Invest Dermatol., 104(suppl):12-13.
11. Paus, R., Slominski, A., and Czarnetzki, B.M. (1994) Alopecia areata: an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I-expression in the proximal anagen hair bulb? Yale J. Biol. Med., 66:541-554.
12. Peereboom-Wynia, J.D., Koerten, H.K., Van Joost, T.H., and Stolz, E. (1989) Scanning electron microscopy comparing exclamation-mark hairs in alopecia areata with normal fibers broken by traction. Clin. Exp. Dermatol., 14:47-50.
13. Sugiyama, S., and Kukita, A. (1976) Melanocyte reservoir in the hair follicle during the hair growth cycle: An electron microscopic study. In: Biology and Disease of the Hair. K. Toda, Y. Ishibashi, Y. Hori, and F. Morikawa, eds. University of Tokyo Press, Tokyo, pp 181-200.
14. Sugiyama, S. (1979) Mode of redifferentiation and melanogenesis of melanocytes in mouse hair follicles. J. Ultrastruct Res. 67:40-54.
15. Tobin, D.J., Fenton, D.A., and Kendall, M.D. (1990) Ultrastructural study of exclamation-mark hair shafts in alopecia areata. J. Cut Pathol., 17:348-354.
16. Tobin, D.J., Fenton, D.A., and Kendall, M.D. (1991) Ultrastructural observations on the hair bulb melanocyte and melanosomes in acute alopecia areata. J. Invest Dermatol., 94:803-807.
17. Tobin, D.J., Orentreich, N., Fenton, D.A., and Bystryn, J.-C. (1994) Antibodies to hair follicles in alopecia areata. J. Invest Dermatol., 102:721-724.
18. Tobin, D.J., Colen, S.R., and Bystryn, J.-C. (1995) Isolation and long term culture of human hair follicle melanocytes. J. Invest Dermatol., 104:86-89.
19. Tobin, D.J., Hann, S.-K., Song, M-S., and Bystryn, J-C. (1997) Hair follicle structures targeted by antibodies in alopecia areata. Arch Dermatol 133:57-61.
20. Tobin, D.J., and Bystryn, J.-C. (1997) Different populations of melanocytes are present in hair follicles and epidermis. Pigment Cell Res 9:304-310.
21. Tobin, D.J., and Bystryn, J-C. (1996) Alopecia areata is associated with antibodies to hair follicle-specific antigens located predominantly in the proliferative region of hair follicles. In: Hair research for the next millennium. D.J. Van Neste and VA. Randall, eds. Elsevier Science B.V., Amsterdam pp. 237-241.
22. Vilanova, X., and de Moragas, J.M. (1963) Alopecia areata. Actas. Dermo-Sifilograficas., 54:337-342.