Structure-activity relationships of α-amino acid ligands for the α2δ subunit of voltage-gated calcium channels

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1138-1141

  Mortell, Kathleen H ^a   Anderson, David J ^a   Lynch III, James J ^a   Nelson, Sherry L ^a   Sarris, Kathy ^a   McDonald, Heath ^a   Sabet, Reza ^a   Baker, Scott ^a   Honore, Prisca ^a   Lee, Chih Hung ^a   Jarvis, Michael F ^a   Gopalakrishnan, Murali ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

2 ; Amino acids; Gabapentin; Voltage gated calcium channel

Indexed keywords

ALPHA AMINO ACID; AMINO ACID DERIVATIVE; BENZYLHOMOCYSTEINE DERIVATIVE; CYCLOHEXYLALANINE DERIVATIVE; GABAPENTIN; LIGAND; PHENYLGLYCINE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BINDING; DRUG EFFICACY; DRUG IDENTIFICATION; IN VIVO STUDY; NONHUMAN; PAIN; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANIMALS; BENZENE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; LIGANDS; MOLECULAR STRUCTURE; PAIN; PROTEIN SUBUNITS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 31344474636     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.108     Document Type: Article

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