Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 8, 1997, Pages 869-873

  Takai, Satomi ^a   Matsuda, Ayuka ^a   Usami, Yoshiko ^a   Adachi, Tetsuo ^a   Sugiyama, Tadashi ^b   Katagiri, Yoshihiro ^b   Tatematsu, Masae ^c   Hirano, Kazuyuki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY HOSPITAL   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

Amidase; Biotransformation; Carboxylesterase; Drug metabolism; Prodrug

Indexed keywords

ACETYLSALICYLIC ACID; CARBOXYLASE; DELAPRIL; IMIDAPRIL; TEMOCAPRIL;

AMINO ACID SEQUENCE; ARTICLE; DRUG HYDROLYSIS; DRUG PROTEIN BINDING; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PURIFICATION; HUMAN; LIVER METABOLISM; NONHUMAN; RABBIT; SEQUENCE HOMOLOGY;

EID: 0030845278     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.869     Document Type: Article

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