Cremophor EL releases cyclosporin A adsorbed on blood cells and blood vessels, and increases apparent plasma concentration of cyclosporin A

International Journal of Pharmaceutics

Volumn 293, Issue 1-2, 2005, Pages 137-144

  Jin, Mingji ^a   Shimada, Tsutomu ^a   Yokogawa, Koichi ^a,b   Nomura, Masaaki ^a   Mizuhara, Yasuharu ^b,c   Furukawa, Hiroyuki ^a   Ishizaki, Junko ^a   Miyamoto, Ken Ichi ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b Graduate School of Medical Science   (Japan)

^c TSUMURA AND CO   (Japan)

Author keywords

Adsorption; Blood cells; Blood vessel; Cremophor EL; Cyclosporin A; Disposition kinetics

Indexed keywords

ALPHA TOCOPHEROL; CREMOPHOR; CYCLOSPORIN A; FLORID F; PACLITAXEL; SURFACTANT;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CELL; BLOOD VESSEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ADSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG RELEASE; DRUG UPTAKE; ERYTHROCYTE; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; TISSUE LEVEL;

EID: 15044356960     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.12.023     Document Type: Article

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