Decrease in oral bioavailability of ciclosporin by intravenous pulse of methylprednisolone succinate in rats

Journal of Pharmacy and Pharmacology

Volumn 56, Issue 10, 2004, Pages 1259-1266

  Konishi, Hiroki ^a   Sumi, Masaki ^a   Shibata, Nobuhito ^b   Takada, Kanji ^b   Minouchi, Tokuzo ^a   Yamaji, Akira ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE HOSPITAL   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYTOCHROME P450 3A; GLYCOPROTEIN P; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; PRODRUG; RHODAMINE 123; TRIAZOLAM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE ACID SYNTHESIS; BILE FLOW; CLINICAL PROTOCOL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CROSS REACTIVITY; DRUG HYDROXYLATION; DRUG MEGADOSE; DRUG PULSE THERAPY; DRUG TRANSPORT; ENZYME METABOLISM; GASTROINTESTINAL ABSORPTION; IN VIVO STUDY; INTESTINE LOOP; MALE; MICROSOME MEMBRANE; NONHUMAN; PROTEIN FUNCTION; RAT; SMALL INTESTINE ABSORPTION; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARYL HYDROCARBON HYDROXYLASES; BILE; BIOLOGICAL AVAILABILITY; CYCLOSPORINE; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALE; METHYLPREDNISOLONE HEMISUCCINATE; OXIDOREDUCTASES, N-DEMETHYLATING; P-GLYCOPROTEIN; PRODRUGS; PULSE THERAPY, DRUG; RATS; RATS, SPRAGUE-DAWLEY;

EID: 5644239801     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357044481     Document Type: Article

References (33)

1. Akhlaghi, F., Trull, A. K. (2002) Distribution of cyclosporin in organ transplant recipients. Clin. Pharmacokinet. 41: 615-637
2. 450 caused by phenobarbital. Gastroenterology 88: 458-467
3. Cakaloglu, Y., Marinos, G., Marsden, J., Peters, T. J., Williams, R., Tredger, J. M. (1993) Localization of cyclosporin A absorption in rat small bowel and the effect of bile. Clin. Sci. 84: 675-679
4. Campana, C., Regazzi, M. B., Buggia, I., Molinaro, M. (1996) Clinically significant drug interactions with cyclosporin. An update. Clin. Pharmacokinet. 30: 141-179
5. Chanussot, F., Botta-Fridlund, D., Lechene de la Porte, P., Sbarra, V., Portugal, H., Pauli, A.-M., Hauton, J., Gauthier, A., Lafont, H. (1992) Effects of cyclosporine and corticosteroids on bile secretion in the rat. Transplantation 54: 226-231
6. Dresser, G. K., Spence, J. D., Bailey, D. G. (2000) Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin. Pharmacokinet. 38: 41-57
7. Faulds, D., Goa, K. L., Benfield, P. (1993) Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs 45: 953-1040
8. Hsing, S., Gatmaitan, Z., Arias, I. M. (1992) The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa. Gastroenterology 102: 879-885
9. Igarashi, T., Yano, I., Saito, H., Inui, K. (2003) Decreased cyclosporin A concentrations in the absorption phase using micro-emulsion preconcentrate formulation in rats with cisplatin-induced acute renal failure. Biol. Pharm. Bull. 26: 1591-1595
10. Kahan, B. D. (1989) Cyclosporine. N. Engl. J. Med. 321: 1725-1738
11. Kanamitsu, S., Ito, K., Green, C. E., Tyson, C. A., Shimada, N., Sugiyama, Y. (2000) Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4. Pharm. Res. 17: 419-426
12. Konishi, H., Sumi, M., Shibata, N., Takada, K., Minouchi, T., Yamaji, A. (2004) Influence of intravenous methylprednisolone pulse treatment on the disposition of ciclosporin and hepatic CYP3A activity in rats. J. Pharm. Pharmacol. 56: 477-483
13. Lee, J. S., Paull, K., Alvarez, M., Hose, C., Monks, A., Grever, M., Fojo, A. T., Bates, S. E. (1994) Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen. Mol. Pharmacol. 46: 627-638
14. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
15. Mohri, K., Uesawa, Y. (2001) Enzymatic activities in the microsomes prepared from rat small intestinal epithelial cells by differential procedures. Pharm. Res. 18: 1232-1236
16. Monsarrat, B., Chatelut, E., Royer, I., Alvinerie, P., Dubois, J., Dezeuse, A., Roche, H., Cros, S., Wright, M., Canal, P. (1998) Modification of paclitaxel metabolism in a cancer patient by induction of cytochrome P450 3A4. Drug Metab. Dispos. 26: 229-233
17. Oka, A., Oda, M., Saitoh, H., Nakayama, A., Takada, M., Aungst, B. J. (2002) Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells. Biol. Pharm. Bull. 25: 393-396
18. Perico, N., Remuzzi, G. (1997) Prevention of transplant rejection: current treatment guidelines and future developments. Drugs 54: 533-570
19. Perloff, M. D., von Moltke, L. L., Greenblatt, D. J. (2004) Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats. Xenobiotica 34: 133-150
20. Pichard, L., Fabre, I., Daujat, M., Domergue, J., Joyeux, H., Maurel, P. (1992) Effect of corticosteroids on the expression of cytochromes P450 and cyclosporin A oxidase activity in primary cultures of human hepatocytes. Mol. Pharmacol. 41: 1047-1055
21. Ptachcinski, R. J., Venkataramanan, R., Burckart, G. J., Hakala, T. R., Rosenthal, J. T., Carpenter, B. J., Taylor, R. J. (1987) Cyclsporine - high-dose steroid interaction in renal transplant recipients: assessment by HPLC. Transplant. Proc. 19: 1728-1729
22. Salphati, L., Benet, L. Z. (1998) Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem. Pharmacol. 55: 387-395
23. Schuetz, E. G., Guzelian, P. S. (1984) Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism. J. Biol. Chem. 259: 2007-2012
24. Sérée, E., Villard, P. H., Hevér, A., Guigal, N., Puyoou, F., Charvet, B., Point-Scomma, H., Lechevalier, E., Lacarelle, B., Barra, Y. (1998) Modulation of MDR1 and CYP3A expression by dexamethasone: evidence for an inverse regulation in adrenals. Biochem. Biophys. Res. Commun. 252: 392-395
25. Shibata, N., Ohmae, T., Hoshino, N., Minouchi, T., Yamaji, A. (1999) Influence of glycerol-induced acute renal failure on the pharmacokinetics of cyclosporin in rats. J. Pharm. Pharmacol. 51 397-404
26. Shibata, N., Morimoto, J., Hoshino, N., Minouchi, T., Yamaji, A. (2000) Factors that affect absorption behavior of cyclosporin A in gentamicin-induced acute renal failure in rats. Ren. Fail. 22 181-194
27. Shibata, N., Inoue, Y., Fukumoto, K., Nishimura, A., Fukushima, K., Yoshikawa, Y., Spiteller, G., Takada, K. (2004) Evaluation of factors to decrease bioavailability of cyclosporin A in rats with gentamicin-induced acute renal failure. Biol. Pharm. Bull. 27 384-391
28. Shimada, T., Terada, A., Yokagawa, K., Kaneko, H., Nomura, M., Kaji, K., Kaneko, S., Kobayashi, K., Miyamoto, K. (2002) Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy. Transplantation 74: 1419-1424
29. van Gelder, T. (2002) Drug interactions with tacrolimus. Drug Saf. 25: 707-712
30. Yarimagan, H. S., Bor, N. M. (1986) Changes of bile lipid composition induced by methylprednisolone. Biochem. Med. Metab. Biol. 35: 7-11
31. Yates, C. R., Chang, C., Kearbey, J. D., Yasuda, K., Schuetz, E. G., Miller, D. D., Dalton, J. T., Swaan, P. W. (2003) Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm. Res. 20: 1794-1803
32. Yokogawa, K., Shimada, T., Higashi, Y., Itoh, Y., Masue, T., Ishizaki, J., Asahi, M., Miyamoto, K. (2002) Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone. Biochem. Pharmacol. 63: 777-783
33. Yumoto, R., Murakami, T., Nakamoto, Y., Hasegawa, R., Nagai, J., Takano, M. (1999) Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds. J. Pharmacol. Exp. Ther. 289: 149-155